Cerebro-rhino-orbital mucormycosis and aspergillosis coinfection in a patient with diabetes mellitus: A case report

Zayet, Souheil; Zaghdoudi, Aida; Ammari, L.; Kilani, B.

doi:10.1016/j.idcr.2020.e01022

Cited by 16 publications

(14 citation statements)

References 13 publications

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“…Coinfection with mucormycosis and aspergillosis is a rare entity, and very few cases have been published in the literature. Johnson et al [ 18 ] reported a case of combined probable pulmonary aspergillosis and possible mucormycosis in a diabetic male with COVID-19 in the ICU who was treated with liposomal amphotericin B. Zayet et al reported a case of cerebro-rhino-orbital mucormycosis and aspergillosis coinfection in a patient with diabetes mellitus with complete recovery after antifungal therapy combined with surgical debridement [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Coinfection by Aspergillus and Mucoraceae Species in Two Cases of Acute Rhinosinusitis as a Complication of COVID-19

Tabarsi

Sharifynia

Toutkaboni

et al. 2022

Case Reports in Medicine

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Acute invasive fungal rhinosinusitis (AIFR) is a life-threatening infection often found in immunocompromised patients. In the COVID-19 era, reports of AIFR have emerged, with high mortality and morbidity rate. This paper presents two cases of COVID-19 associated AIFR with the combined proven fungal etiology of Aspergillus flavus and Rhizopus arrhizus in case 1 and Aspergillus fumigatus and Rhizopus arrhizus in case 2. Both patients received liposomal amphotericin B then posaconazole combined with aggressive surgical debridement of necrotic tissues with a favorable clinical outcome. Mixed etiology AIFR can influence the outcome; hence, further studies are required upon this new threat.

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Section: Discussionmentioning

confidence: 99%

Coinfection by Aspergillus and Mucoraceae Species in Two Cases of Acute Rhinosinusitis as a Complication of COVID-19

Tabarsi

Sharifynia

Toutkaboni

et al. 2022

Case Reports in Medicine

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“…There are some reports on fungal co-infections in AIFR. Zayet et al reported a case of cerebro-rhino-orbital mucormycosis and aspergillosis coinfection in a patient with diabetes mellitus with complete recovery after amphotericin B deoxycholate then voriconazole in combination with surgical debridement [ 9 ]. It was assumed that a combination of risk factors, including COVID-19 per se, diabetes mellitus, and corticosteroid treatment, had led to mixed infections in the presented case.…”

Section: Discussionmentioning

confidence: 99%

Mixed etiology COVID-19 associated acute rhinosinusitis caused by two Aspergillus species

Tabarsi

Sharifynia

Toutkaboni

et al. 2022

Annals of Medicine &Amp; Surgery

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Introduction Acute invasive fungal rhino‐sinusitis (AIFR) is a life-threatening infection that is mostly found in immunocompromised patients with serious morbidity and mortality. Recently, reports of AIFR have also emerged among SARS-CoV-2 infected patients. Case presentation A 50-year-old diabetic woman, previously diagnosed with COVID-19 pneumonia, was presented to the hospital with left facial pain on day 12 after discharge. Paranasal sinuses computed tomography was performed and according to the mucosal thickening in both maxillary sinuses and ethmoidal air cells, the patient underwent functional endoscopic sinus surgery (FESS) and necrosis were observed. The histopathologic examination revealed mycelium with septation suspected to Aspergillus and the culture was consistent with Aspergillus flavus and also Aspergillus niger . We reported a case of COVID-19 associated AIFR with two combined Aspergillus species from Iran. The patient received liposomal amphotericin B, which then switched to voriconazole combined with aggressive surgical debridement of necrotic tissues with a clinically favorable outcome. Conclusion Mixed etiology AIFR can influence the outcome. However, further investigation is required upon this new threat.

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“…Another target could be Pentraxin 3 (PTX3), which has been shown to be a promising marker for aspergillosis ( Cunha et al, 2014 ). Mucormycosis frequently co-occurs with aspergillosis ( Alfano et al, 2006 ; Tsikala-Vafea et al, 2020 ; Johnson et al, 2021 ; Zayet et al, 2021 ). SNPs in PRRs like Toll-like receptors (TLRs) have already been associated with increased susceptibility to fungal infections ( Bergantim et al, 2013 ; Wang et al, 2013 ; Fischer et al, 2016 ; Zhang et al, 2019 ; Aqsa et al, 2020 ).…”

Section: Current Aspects In Diagnosis and Prediction Of Other Fungal ...mentioning

confidence: 99%

Mini Review: Risk Assessment, Clinical Manifestation, Prediction, and Prognosis of Mucormycosis: Implications for Pathogen- and Human-Derived Biomarkers

Acosta-España

Voigt

2022

Front. Microbiol.

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Mucormycosis is a fungal disease caused by members of the fungal order Mucorales, which are abundantly found in terrestrial environments. The fungi propagate clonally via mitospores, which are transmitted to humans through the air and cause superficial or invasive infections. The disease has emerged in recent years and coincides generally with immunosuppression on the patient side. Mucormycosis is still rarely recognized in the clinical because of its unspecific symptoms which often triggers misdiagnosis with bacterial or viral infections leading to prolonged therapeutic cycles and loss of valuable time to manage mucormycosis properly. Infected patients develop various clinical forms, most notably ranging from rhinocerebral via pulmonary to gastrointestinal forms. Traditional diagnosis is based on culture and histopathologic examinations of the affected tissue. But, the achievement of a precise result is time-consuming, labor-intensive, requires mycological expertise and the finding appears often too late. A rapid and precise diagnosis is mandatory because symptoms are non-specific and the disease is rapidly progressing with often fatal outcome. Mucormycosis was increasingly associated with other infections and underlying conditions and risk factors causing comorbidities, which are difficult to successfully manage. This mini-review summarizes the current knowledge on the epidemiology and causative agents of mucormycosis, transmission, risk factors, clinical presentation, diagnosis, and highlights the lack of appropriate biomarkers on the pathogen and the host sides for rapid pathogen and host susceptibility detection, respectively. Fungal antigens and single nucleotide polymorphisms (SNPs) in human host genes are useful for the assessment of susceptibility. This mini-review addresses possibilities for early prediction of susceptibility to mucormycosis based on forecasting of the risk of infection with fungal pathogens other than Mucorales. The topic of early prediction and diagnosis of mucormycosis represents a current research gap and highlights the importance of potential future developments in the area of risk assessment, susceptibility prognosis in conjunction with early diagnosis to reduce mortality in patients suffering from mucormycosis.

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Cerebro-rhino-orbital mucormycosis and aspergillosis coinfection in a patient with diabetes mellitus: A case report

Cited by 16 publications

References 13 publications

Coinfection by Aspergillus and Mucoraceae Species in Two Cases of Acute Rhinosinusitis as a Complication of COVID-19

Coinfection by Aspergillus and Mucoraceae Species in Two Cases of Acute Rhinosinusitis as a Complication of COVID-19

Mixed etiology COVID-19 associated acute rhinosinusitis caused by two Aspergillus species

Mini Review: Risk Assessment, Clinical Manifestation, Prediction, and Prognosis of Mucormycosis: Implications for Pathogen- and Human-Derived Biomarkers

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