Cerebral venous thrombosis revealing an ulcerative colitis

Taous, Abdellah; Berri, Maha Ait; Lamsiah, Taoufik; Zainoun, B.; Ziadi, T.; Rouimi, A.

doi:10.11604/pamj.2016.23.120.9186

Cited by 10 publications

(13 citation statements)

References 13 publications

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“…CVST has been reported as an uncommon and devastating complication of IBD. The incidence of CVST in our study was 0.48%, which is slightly lower than that noted in a previous study 3 . The difference might be due to different races and nationalities.…”

Section: Discussioncontrasting

confidence: 79%

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Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study

Wang

Zhang

Bai

et al. 2021

Sci Rep

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Cerebral venous sinus thrombosis (CVST) is a rare and devastating complication of inflammatory bowel disease (IBD). Early diagnosis and prompt treatment could improve prognosis. The aim of our study was to investigate the clinical data and predictive factors of inflammatory bowel disease in patients with a diagnosis of CVST. All IBD patient data were collected from July 2013 and September 2020. Clinical data, predictive factors and prognosis were compared between IBD patients with CVST and the IBD control group. The incidence of CVST in our study was 0.48%. The mean age of IBD patients with CVST was 34.9 years. The average duration of IBD was 4 years when cerebrovascular events occurred. The clinical presentation of CVST included headache (73.1%), vomiting (30.8%), limb dysmetria (26.9%), speech impairment (11.5%), blurred vision (7.7%), epileptic seizures (7.7%) and drowsiness (3.8%). The most common location for CVST was the transverse sinus (61.5%) followed by the superior sagittal sinus (30.8%). Anaemia, low albumin and elevated d-dimer were independent predictors of CVST in patients with IBD. Anticoagulation therapy was effective. The prognosis of IBD patients with CVST was worse than that of IBD patients without CVST. Early identification of the risk and clinical features of CVST in IBD patients is important. Prompt antithrombotic therapy is a safe and effective treatment.

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Section: Discussioncontrasting

confidence: 79%

“…Cerebral venous sinus thrombosis (CVST) is a serious complication of IBD with high mortality. The reported incidence of CVST in IBD varies between 0.5 and 6.7% 3 . Clinical symptoms of CVST could vary from headaches to coma, thus making diagnosis difficult.…”

Section: Introductionmentioning

confidence: 99%

Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study

Wang

Zhang

Bai

et al. 2021

Sci Rep

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“…Treatment of IBD with CVST was the same with patients without IBD. The rst-line treatment for CVST is adjusted-dose low-molecular-weight heparin [2] . Novel oral anticoagulants was also recommended for its effectiveness and safety in treating cerebral venous thrombosis [16] .…”

Section: Discussionmentioning

confidence: 99%

“…Cerebral venous sinus thrombosis (CVST) is a serious complication of IBD with high mortality. The reported incidence of CVST in IBD varied between 0.5-6.7% [2] . Clinical symptoms of CVST could vary from headaches to coma thus making diagnosis di cult.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Venous Sinus Thrombosis in Patients With Inflammatory Bowel Disease: A Retrospective Study

Wang

Zhang

Bai

et al. 2021

Preprint

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BACKGROUND: Cerebral venous sinus thrombosis (CVST) is a rare and devastating complication of inflammatory bowel disease (IBD). Early diagnose and prompt treatment could improve prognosis.AIM: The aim of our study was to investigate the clinical data and risk factors of inflammatory bowel disease with diagnosis of CVST. METHODS: All data of IBD patients were collected from July 2013 and September 2020. Clinical data, risk factors and prognosis were compared between CVST in IBD patients and IBD control group. RESULTS: The incidence of CVST in our study was 0.48%. The mean age of IBD patients with CVST was 34.9 years. Average disease duration of IBD was 4 years when cerebrovascular events occur. Clinical presentation of CVST included headache (73.1%), vomiting (30.8%), limb dysmetria (26.9%), speech impairment (11.5%), blurred vision (7.7%), Epileptic seizures (7.7%) and drowsiness (3.8%). The most common location for CVST was transverse sinus (61.5%), followed by superior sagittal sinus (30.8%). Anemia, low albumin and elevated D-dimer were independent predictors of CVST in IBD patients. Anticoagulation therapy was effective. Prognosis of IBD patients with CVST was worse than those without CVST.CONCLUSION: Early identification the risk of and clinical features of CVST in IBD patients is important. Prompt antithrombotic therapy is safe and effective treatment.

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“…These atypical and variable manifestations may potentially result in delays in diagnosis. Furthermore, the focus during acute presentation with a catastrophic neurological event may shift away from the underlying IBD and the severe inflammation‐related pathophysiologic changes which are causing the neurologic event potentially thereby delaying the evaluation and treatment of underlying IBD …”

Section: Discussionmentioning

confidence: 99%

Cerebral venous thrombosis as presenting manifestation of inflammatory bowel disease (IBD)

et al. 2019

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Background: Venous thrombosis is an important complication in patients with inflammatory bowel disease (IBD) and has multifactorial origin mainly related to haemostatic changes in the presence of active inflammation. In addition, number of coagulation abnormalities may co-exist in active IBD many of which return to normal once inflammatory process is controlled. Cerebral venous thrombosis (CVT) is a very rare but potentially serious extra-intestinal feature in IBD Aim: To describe 2 cases of CVT associated with IBD and review the literature. Materials and methods:Records of 2 patients presenting to our unit with CVT and diagnosed to have IBD were reviewed. The clinical, laboratory, endoscopic and imaging data reviewed. We did a comprehensive literature Pubmed search using the search terms inflammatory bowel disease, colitis and venous thrombosis. Results:We report 2 cases with CVT from UC as a presenting manifestation. Both patients required biologics to control the severe colitis and one had some residual deficits in neurological function. In both patients, cerebral imaging improved on follow up Conclusions: Due to the rarity and variability in presentation, CVT as a presenting manifestation of IBD may be overlooked in emergency departments. Prompt diagnosis, initiation of anticoagulation and control of the pro-coagulant state with treatment of colitis can lead to optimal recovery.

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Cerebral venous thrombosis revealing an ulcerative colitis

Cited by 10 publications

References 13 publications

Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study

Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study

Cerebral Venous Sinus Thrombosis in Patients With Inflammatory Bowel Disease: A Retrospective Study

Cerebral venous thrombosis as presenting manifestation of inflammatory bowel disease (IBD)

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