Cerebral venous thrombosis: a practical review

Borhani-Haghighi, Afshin; Hooshmandi, Etrat

doi:10.1093/postmj/qgad103

Cited by 3 publications

(1 citation statement)

References 96 publications

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“…Cerebral venous sinus thrombosis (CVST) is a relatively rare but severe condition characterized by the formation of blood clots in the dural venous sinuses of the brain [169]. These sinuses are responsible for draining blood from the brain.…”

Section: Cerebral Venous Sinus Thrombosismentioning

confidence: 99%

A Literature Review of Movement Disorder Associated with Medications and Systemic Diseases

Pitton Rissardo,

Fornari Caprara

2024

Preprint

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Movement disorders can be associated with various drugs and systemic diseases, posing diagnostic challenges for clinicians. This review explores the spectrum of movement disorders associated with pharmacological agents and medical conditions. Drug-induced movement disorders encompass a broad range of conditions resulting from exposure to medications that affect several neurotransmitters. Neuroleptic medications can lead to tardive dyskinesia, characterized by involuntary, repetitive movements. Antipsychotics and antiemetics, including metoclopramide, may induce acute dystonic reactions. Other drugs, such as dopamine receptor-blocking agents, can contribute to drug-induced parkinsonism. Beyond medications, movement disorders can also arise secondary to systemic diseases. Metabolic disorders like Wilson's disease, characterized by copper accumulation, may manifest as chorea or dystonia. Inflammatory conditions such as rheumatoid arthritis and systemic lupus erythematosus can result in secondary movement disorders due to autoimmune-mediated processes affecting the central nervous system. Movement disorders linked to drugs or systemic diseases often necessitate a thorough clinical evaluation, including detailed medication histories and comprehensive systemic assessments. Neuroimaging, laboratory investigations, and, in some cases, cerebrospinal fluid analyses and electrodiagnostic studies help in establishing accurate diagnoses. Management involves addressing the underlying cause, modifying medications, and employing symptomatic treatments.

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Section: Cerebral Venous Sinus Thrombosismentioning

confidence: 99%

A Literature Review of Movement Disorder Associated with Medications and Systemic Diseases

Pitton Rissardo,

Fornari Caprara

2024

Preprint

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Sex differences in clinical profile and risk factors of cerebral venous sinus thrombosis at a high-altitude area: A 10-year retrospective cross-sectional study

Zarimeidani,

Rahmati,

Mokary

et al. 2024

Medicine

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Cerebral venous sinus thrombosis (CVST) is an uncommon disorder with an increased mortality risk. Data on the sex-specific clinical profile and related factors can be practical in clinical diagnosis and management. Thus, we aimed to assess CVST characteristics in Shahrekord, the most elevated city among the centers of the provinces of Iran, referred to as the Roof of Iran. In this retrospective cross-sectional study, we reviewed the hospital records of 127 CVST patients between April 2013 and June 2023 to analyze the demographic characteristics, clinical profile, disease outcomes, and risk factors. STROBE guidelines were used to report this study. Females comprised 65.3% of the study. Females’ age was almost equal to male patients (37.51 ± 13.95 years vs 38.09 ± 16.18 years, P = .832), and more than half of the patients (59.1%) were married. Clinical characteristics showed no significant difference between the sexes. In contrast to males, females had multifarious risk factors. However, the main risk factors for both sexes were CVST and hypertension. Most patients had 1 sinus affected (55.9%), and the location of thrombosis was mainly in the right transverse sinus in males (38.63%) and superior sagittal sinus in females (33.73%). However, those with more than 2 affected sinuses were mostly women. Regarding radiological findings, sinusitis was significantly seen in men (18.18% vs 3.61%). Among laboratory data, females significantly had higher erythrocyte sedimentation rate levels than males (21.66 ± 24.39 vs 9.60 ± 8.55). This study indicates that among CVST patients, men have significantly higher occurrences of sinusitis, and higher levels of erythrocyte sedimentation rate were observed in women. However, no other significant differences were found. More extensive studies are essential to fully comprehend the sex-specific aspects of CVST.

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Development of an Innovative Surgical Suture Material That Prevents the Formation of Arterial Thrombosis

Yusupkhadzhieva,

Yandieva,

Arsanova

et al. 2024

Arch Pharm Pract

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One of the most serious complications after surgical interventions on the arteries of the lower extremities is thrombosis of the vascular prosthesis. Unfortunately, it is almost impossible to protect the patient from contact with the surgical thread with flowing blood, which makes the location of the surgical operation a focus of thrombosis. The purpose of this scientific study is to evaluate the possibility of modifying the surface of a polypropylene thread with heparin using chemical inoculation in order to increase the thromboresistant properties of the suture material. To do this, a polyhydroxybutyrate/oxivalerate copolymer and a heparin solution were applied to the surface of the polypropylene filament. An additional sublayer of polymethacrylyl chloride contributed to the strong inoculation of heparin to the polymer. The polymer substrate reacted with heparin to form strong covalent ester bonds. Applying a thin and uniform layer of polyhydroxybutyrate/oxivalerate to the thread with a thickness of no more than 4 microns makes its surface smooth. After chemical modification and application of heparin to the surface of the thread, it acquired a uniform spongy structure, due to the formation of a new polymer layer with firmly grafted heparin. Thus, it is possible to create a bio-and hemocompatible coating based on a biodegradable polymer and heparin on the surface of a polypropylene thread.

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Cerebral venous thrombosis: a practical review

Cited by 3 publications

References 96 publications

A Literature Review of Movement Disorder Associated with Medications and Systemic Diseases

A Literature Review of Movement Disorder Associated with Medications and Systemic Diseases

Sex differences in clinical profile and risk factors of cerebral venous sinus thrombosis at a high-altitude area: A 10-year retrospective cross-sectional study

Development of an Innovative Surgical Suture Material That Prevents the Formation of Arterial Thrombosis

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