Cerebral tumors: Specific features in children

Koob, Mériam; Girard, Nadine

doi:10.1016/j.diii.2014.06.017

Cited by 41 publications

(44 citation statements)

References 75 publications

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“…31 Fetuses and young children may be especially vulnerable to these insecticides because of their immature nervous systems and their rapid dividing cells. 32 Nevertheless, we could not find any evidence in the literature of pyrethroids passing through the placental barrier.…”

Section: Discussioncontrasting

confidence: 55%

“…While our study was not able to identify the actual chemicals used by mothers, it is likely that these could include organophosphate or pyrethroid insecticides, which are widely used in residential areas . Fetuses and young children may be especially vulnerable to these insecticides because of their immature nervous systems and their rapid dividing cells . Nevertheless, we could not find any evidence in the literature of pyrethroids passing through the placental barrier.…”

Section: Discussionmentioning

confidence: 79%

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Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE)

Bagazgoïtia

Bailey

Orsi

et al. 2017

Intl Journal of Cancer

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Some previous epidemiological studies have suggested that pesticide exposure during pregnancy may have a possible role in the development of childhood brain tumors (CBT). We pooled data from two French national population-based, case-control studies to investigate the association between maternal residential use of pesticides during pregnancy and the risk of CBT. The mothers of 437 CBT cases and 3,102 controls aged under 15 years who resided in France at diagnosis/interview, frequency-matched by age and gender, answered a structured telephone interview conducted by trained interviewers. Unconditional logistic regression was used to estimate pooled odds ratio (OR) and 95% confidence intervals (95% CI). CBT was significantly associated with the maternal home use of pesticides during pregnancy (OR 1.4, 95% CI 1.2-1.8) and, more specifically, with insecticide (OR 1.4, 1.2-1.8). We could not draw any conclusions about herbicides and/or fungicides because few women used them during pregnancy and most of these mothers also used insecticides. Although potential recall bias cannot be excluded, our findings of this pooled analysis support the hypothesis that residential maternal use of pesticides during pregnancy and particularly insecticides may increase the risk of CBT. Future investigations to verify these findings and to explore for CBT subtypes and dose-response are necessary to have a better understanding of the possible role of pesticides in etiology of CBT.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 79%

Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE)

Bagazgoïtia

Bailey

Orsi

et al. 2017

Intl Journal of Cancer

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“…Although the finding above is supported by another report from our sub region [4], it differed from reports from other regions in our country [1,23,30] as well as previous studies in other parts of the world [4,11,33]. This may suggest some geographical variability in the topographical distribution of brain tumors which has been reported by some authors to be influenced by age [3,15]. Craniopharyngioma (n = 21) is the most common tumor among histopathologically confirmed cases in our series followed by medulloblastoma TABLE 2.…”

Section: Discussioncontrasting

confidence: 55%

Pediatric Brain tumors in Southeast Nigeria; A prospective longitudinal cohort study

Uche

Ajuzieogu

et al. 2019

Preprint

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Background: Pediatric brain tumors (PBT’s) from previous studies are associated with poor outcomes in our sub region. Methods. An 8 -year single center prospective study. All cases investigated with neuroimaging and treated were enrolled. Data was analyzed with SPSS (Inc.) Chicago IL, USA version 23. Chi Square test, One-way Anova and confidence limits were used to evaluate associations at the 95% level of significance. Ethical approval was obtained for our study. Results: 103 patients were enrolled, 92 satisfied the study criteria. There were 45 males and 39 females, M: F=0.8. The mean age was 9.5±2.1 years 95%CI with a range of 7 months to 16 years. The most common symptom was headache for supratentorial lesions (73%) and gait disturbance (80.2%) for infratentorial lesions. More tumors were supratentorial in location (51 (55.4%), while 35(38.1%) were infratentorial. Craniopharyngiomas (n=22), medulloblastomas (n=17) and astrocytomas (n=12) were the most common tumors. Hemoglobin genotype (AA and AS) had some influence on tumor phenotype FT, P=0.033. 76 cases were microsurgically resected while 16 patients were treated with radiotherapy alone. The 30-day mortality for operated cases is 7.2±0.7%. Overall 1-year and 5-year survival was 66.7% and 52.3 % respectively. Survival School performance varied among treatment subgroups Conclusion: Survival profile in this series suggests some improvement in comparison to previous studies from our region. Keywords: Pediatric brain tumors, microneurosurgery, radiotherapy, survival

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“…The pre-operative images obtained using these techniques correlated well with the pathological findings for those infants who underwent surgical tumor resection. Thus, ultrasound imaging combined with the use of enhanced CT and MRI may facilitate a correct diagnosis of the intracranial location of the majority of common brain tumors, greatly improving the accuracy of the diagnosis (30,31). …”

Section: Discussionmentioning

confidence: 99%

Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study

Wei

Zhao

et al. 2015

Oncology Letters

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The aim of present study was to evaluate the incidence, clinical symptoms, pathological characteristics, surgical treatment strategies and prognosis of brain tumors in children aged two and under. The current study obtained data regarding 32 consecutive infants and young children aged two years and under, who were treated for brain tumors in the Children’s Hospital of Fudan University (Shanghai, China) between 2003 and 2013. The types of tumor, clinical manifestations, location, histological features, applied treatment strategies and outcomes were retrospectively evaluated. The male to female ratio was 1.13:1, and among a total of 32 tumors, 14 (43.8%) were suptratentorial and 18 (56.3%) were infratentorial. Intracranial hypertension was the most common onset symptom, and astrocytoma was the most common tumor type (10 cases; 31.3%), followed by ependymoma (nine cases; 28.1%) and medulloblastoma (six cases; 18.8%). Surgical tumor resection was performed in 20 patients (62.5%), who experienced a mean post-operative survival time of 67.6 months. By contrast, conservative treatment with medications was administered in 12 patients (37.5%), with a mean survival time of 25.3 months. Furthermore, four patients underwent conservative therapy combined with ventriculoperitoneal shunting to relieve intracranial pressure arising from cerebrospinal fluid accumulation, resulting in a mean survival time of 10.5 months. In conclusion, the present study indicates that surgical tumor resection may improve the overall prognosis of infants and young children aged two years and under who presented with brain tumors. In addition, ventriculoperitoneal shunts may facilitate pre- and post-operative improvement in clinical symptoms by relieving intracranial pressure; however, the shunts do not appear to increase long-term survival. Furthermore, high surgical risk is an important prognostic factor in this pediatric patient population.

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Cerebral tumors: Specific features in children

Cited by 41 publications

References 75 publications

Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE)

Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE)

Pediatric Brain tumors in Southeast Nigeria; A prospective longitudinal cohort study

Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study

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