Pediatric Brain tumors in Southeast Nigeria; A prospective longitudinal cohort study

Uche, Enoch Ogbonnaya; Uche, Nkechi Judith; Ajuzieogu, Obinna V.; Amuta, Dubem S; Onyia, Ephraim; Eke, Chris; Okafor, John; Emejulu, J K C; Mezue, Wilfred C; Ryttlefors, Mats; Tisell, Magnus

doi:10.21203/rs.2.13963/v2

Cited by 1 publication

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“…With the dwindling economy situation in the country most patients cannot afford modern imaging and available care 11) . Few studies have been done in Nigeria and other sub-Saharan countries studying the clinicopathologic and radiological features of brain tumours 13,16,29,30,37) .…”

Section: Introductionmentioning

confidence: 99%

Profile and Outcome of Management of Brain Tumours in Kaduna Northwestern Nigeria

Sale

Dauda

Kene

et al. 2022

J Korean Neurosurg Soc

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Objective : Tumours of the brain are a rare occurrence accounting for approximately 2% of all neoplasms in adults. Few studies have been done in Nigeria on the profile of brain tumours. The aim of this study is to determine the profile of brain tumours in general and determine the change in Kanofsky Performance Score (KPS) after treatment.Methods : This is a prospective hospital-based study in Kaduna. All consecutive patients over 18 years of age with diagnosis of brain tumours from January 2016 to December 2019 were included in the study. Demographic and clinical data was collected using a proforma during the study. Patients who received treatment were followed up for 12 months. The primary outcome data was the difference in the quality of life as measured by KPS at the point of first contact and at 1-month after treatment and at 12-month follow up. Data obtained was analysed with SPSS version 25.0 for Windows. Descriptive statistics was done to determine the profile. Paired t-test at 95% confidence interval was done to check for significant correlation between the mean KPS.Results : A total of 39 consecutive patients were included in the study. There was a slight male preponderance with a M : F of 1.17 : 1. Meningioma and metastasis were more common in females while gliomas and pituitary tumours were more common in males. The mean age of patients was 49.8 years and standard deviation of 11.8 years. Pituitary tumours were the most common tumours. The most common location of the tumour was frontal lobe followed by the pituitary gland. The mean duration of symptoms before neurosurgical consultation was 38 weeks. The most common presenting symptoms of patient with brain tumour was headache. The quality of life improve compare to the baseline in 81% of patient at discharge and at 1 year follow up. The overall mortality rate was 25.6%.Conclusion : The most common brain tumour in our study is pituitary tumour. Most patients present late. The most common presenting symptoms is headache. There is significant improvement in the KPS of patients following treatment. The overall mortality rate at 1-year post treatment is 25.6%.

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