Cerebral state index during anaesthetic induction: a comparative study with propofol or nitrous oxide

Anderson, R. E.; Barr, G.; Jakobsson, Jan

doi:10.1111/j.1399-6576.2005.00737.x

Cited by 38 publications

(32 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is important to remember that our recordings were simultaneous pairs and that the potential influence of fentanyl or other factors would be the same for each pair. The reliability of the cerebral state monitor to describe the effects of various anaesthetics has not been well evaluated, however its limitations as to the effects to nitrous oxide has been shown [17], and this is to our knowledge the first clinical study of this monitor.…”

Section: Discussionmentioning

confidence: 97%

Cerebral state monitor, a new small handheld EEG monitor for determining depth of anaesthesia

Anderson

Jakobsson

2006

European Journal of Anaesthesiology

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Cerebral state monitor, a new small handheld EEG monitor for determining depth of anaesthesia

Anderson

Jakobsson

2006

European Journal of Anaesthesiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Steady state nitrous oxide alone causes a slightly increase in the highfrequency and theta range activity of EEG, but it does not alter BIS or create a significant degree of hypnosis [10]. A minimal or total lack of effect of opiates and nitrous oxide has been reported on anesthetic depth monitors [5,11]. Therefore, the effects of nitrous oxide and fentanyl may be negligible on the results of this study.…”

Section: Discussionmentioning

confidence: 86%

“…Due to these different calculation algorithms, these indices may be different during anesthesia. Very few studies on the CSI have been published [4][5][6][7][8][9], and none of these have compared the BIS and CSI in patients receiving propofol-fentanyl-nitrous oxide anesthesia. The aim of the study reported here was, therefore, to compare the BIS and CSM (CSI) during propofol-fentanyl-nitrous oxide anesthesia.…”

Section: Introductionmentioning

confidence: 99%

Cerebral state index versus bispectral index during propofol–fentanyl–nitrous oxide anesthesia

Nishiyama¹,

Komatsu

2010

J Anesth

View full text Add to dashboard Cite

show abstract

“…The four parameters consist of the a-ratio, b-ratio, a-ratio, b-ratio and BS. 85 Similarly to the already described commercial indexes, the range of adequate anaesthesia is designed to be between 40 and 60. Anderson et al 86 reported that CSI correlated well with BIS and showed similar patterns and numerical values in day-surgery anaesthesia without muscle relaxation, however, which monitor is the more dependable remains to be established.…”

Section: Cerebral State Monitormentioning

confidence: 99%

Electroencephalogram-based anaesthetic depth monitoring in laboratory animals

Silva

Antunes

2012

Lab Anim

View full text Add to dashboard Cite

Objective measurements of physiological parameters controlled by the autonomic nervous system such as blood pressure, heart rate and respiration are easily obtained nowadays during anaesthesia by the use of monitors: oscillometers, pulseoximeters, electrocardiograms and capnographs are available for laboratory animals. However, the effect-site of hypnotic drugs that cause general anaesthesia is the central nervous system (the brain). In the present, the adjustment of hypnotic drugs in veterinary anaesthesia is performed according to subjective evaluation of clinical signs which are not direct reflexes of anaesthetic effects on the brain, making depth of anaesthesia (DoA) assessment a complicated task. The difficulties in assessing the real anaesthetic state of a laboratory animal may not only result in welfare-threatening situations, such as awareness and pain sensation during surgery, but also in a lack of standardization of experimental conditions, as it is not easy to keep all animals from an experiment in the same DoA without a measure of anaesthetic effect. A direct measure of this dose -effect relationship, although highly necessary, is still missing in the veterinary market. Meanwhile, research has been intense in this subject and methods based on the brain electrical activity (electroencephalogram) have been explored in laboratory animal species. The objective of this review is to explain the achievements made in this topic and clarify how far we are from an objective measure of DoA for animals. The existence of an objective measure of depth of anaesthesia (DoA) for laboratory animals is imperative in order to provide accurate titration of anaesthetic drugs and avoid waking during surgery or overdosage, contributing to the refinement of experiments. Objective measures also diminish the workload and the quantity of anaesthetics administered, allow better outcomes and enable the development of automated systems for anaesthesia delivery. Furthermore, in laboratory animal anaesthesia a precise adjustment of the DoA is essential to keep all animals in an experiment under the same conditions to avoid bias in the results and allow a reduction in the number of animals required to achieve sufficient statistical power.A direct measure of this dose -effect relationship is still missing in veterinary anaesthesia, but research has begun to be carried out, particularly regarding the investigation of methods based on the spontaneous electrical activity of the brain (electroencephalogram [EEG]). The objective of this review is to discuss the achievements made in this topic and clarify how far we are from an objective measure of DoA for animals.

show abstract

Cerebral state index during anaesthetic induction: a comparative study with propofol or nitrous oxide

Abstract: The Cerebral State Index(trade mark) behaves as other depth of anaesthesia monitors with a progressive decrease during propofol induction but loss of consciousness with N(2)0 results in no change in CSI.

Cited by 38 publications

References 15 publications

Cerebral state monitor, a new small handheld EEG monitor for determining depth of anaesthesia

Cerebral state monitor, a new small handheld EEG monitor for determining depth of anaesthesia

Cerebral state index versus bispectral index during propofol–fentanyl–nitrous oxide anesthesia

Electroencephalogram-based anaesthetic depth monitoring in laboratory animals

Contact Info

Product

Resources

About