Cerebral Palsy Among Very Preterm Children in Relation to Gestational Age and Neonatal Ultrasound Abnormalities: The EPIPAGE Cohort Study

Ancel, Pierre‐Yves; Livinec, F.; Larroque, Béatrice; Marret, Stéphane; Arnaud, Catherine; Pierrat,; Dehan, M; Nguyen, Sylvie; Escande, B; Burguet, A.; Thiriez, Gérard; Jc, Picaud; André, M; Breart, Gérard; Kaminski, Monique

doi:10.1542/peds.2005-0091

Cited by 337 publications

(210 citation statements)

References 32 publications

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“…Although our sample size is small, we observed our very preterm ART singletons to have lower median gestational age than the very preterm naturally conceived group (27wks vs 29wks) which could in part account for this increased risk. 22 However further exploration, adjusting for gestational age within this stratum, found the increased risk of CP remained. The loss of a comultiple, estimated to occur in 10% of ART singletons, is another possible explanation for the increased risk.…”

Section: ≥2500mentioning

confidence: 95%

Cerebral palsy after assisted reproductive technology: a cohort study

Goldsmith

McIntyre

Badawi

et al. 2017

Develop Med Child Neuro

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Section: ≥2500mentioning

confidence: 95%

Cerebral palsy after assisted reproductive technology: a cohort study

Goldsmith

McIntyre

Badawi

et al. 2017

Develop Med Child Neuro

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“…They were classified as minor lesions when intraventricular hemorrhage without ventricular dilation or germinal matrix layer hemorrhage was reported. 6 …”

Section: Maternal and Neonatal Datamentioning

confidence: 99%

“…[1][2][3] Cerebral white matter damage, identified principally by using magnetic resonance imaging but also by cranial ultrasound scans, is a powerful predictor of cerebral palsy in very preterm infants. [4][5][6] Recent studies have identified perinatal infection and inflammation as risk factors for cerebral white matter damage. [7][8][9][10] Preterm infants born to mothers with clinical or histologic chorioamnionitis are at risk for adverse neurodevelopmental outcomes, with a particularly high risk of cerebral palsy.…”

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confidence: 99%

Neonatal Infection and 5-year Neurodevelopmental Outcome of Very Preterm Infants

et al. 2013

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WHAT'S KNOWN ON THIS SUBJECT: Neonatal infections are frequent complications in very preterm infants, already at high risk of neurologic and cognitive disabilities. Few studies have linked neonatal infections and neurodevelopmental outcomes. Those that did evaluated children only to the age of 22 months. WHAT THIS STUDY ADDS:This study assessed the respective effects of early-and late-onset sepsis and their association with 5-year neurodevelopmental outcomes. We identified a significant and cumulative risk of cerebral palsy when episodes of early-and late-onset sepsis were associated. abstract OBJECTIVE: To determine whether neonatal infections are associated with a higher risk of adverse neurodevelopment at 5 years of age in a population-based cohort of very preterm children. METHODS:We included all live births between 22 and 32 weeks of gestation, from 9 regions in France, in 1997 (EPIPAGE study). Of the 2665 live births, 2277 were eligible for a follow-up evaluation at 5 years of age: 1769 had a medical examination and 1495 underwent cognitive assessment. Cerebral palsy and cognitive impairment were studied as a function of early-onset sepsis (EOS) and late-onset sepsis (LOS), after adjustment for potential confounding factors, in multivariate logistic regression models. RESULTS:A total of 139 (5%) of the 2665 live births included in the study presented with EOS alone (without associated LOS), 752 (28%) had LOS alone (without associated EOS), and 64 (2%) displayed both EOS and LOS. At 5 years of age, the frequency of cerebral palsy was 9% (157 of 1769) and that of cognitive impairment was 12% (177 of 1495). The frequency of cerebral palsy was higher in infants with isolated EOS (odds ratio [OR] CONCLUSIONS: Neonatal infections in these very preterm infants were associated with a higher risk of cerebral palsy at the age of 5 years, particularly in infants presenting with both EOS and LOS. Pediatrics 2013;132:e372-e380 AUTHORS:

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“…3 The prevalence of this disorder among preterm and very preterm infants is substantially higher. 4,5 The incidence is higher in males than in females (ratio of 1.33:1). 3 Lower socioeconomic status may be a risk factor for cerebral palsy.…”

Section: Epidemiologymentioning

confidence: 99%