Cerebral metabolism in Alzheimer's disease

Jagust, W.J.; Martinez, B. a.; Friedland, R. P.; Budinger, T. F.; Koss, Elizabeth; Ober, Beth A.

doi:10.1212/wnl.39.2.309-a

Cited by 4 publications

(2 citation statements)

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“…Therefore, hippocampal sclerosis may be a major factor in, if not the cause of, temporolimbic hypometabolism. In support of this hypothesis, we note that the same pattern of hypometabolism can also occur in nonepileptic disorders with prominent entorhinohippocampal lesions, such as early Alzheimer's disease (Jagust et al, 1990) and progressive amnesia with bilateral hippocampal atrophy (Y. Samson et al, unpublished observations).…”

Section: Pathophysiological and Clinical Implicationssupporting

confidence: 63%

Is Interictal Temporal Hypometabolism Related to Mesial Temporal Sclerosis? A Positron Emission Tomography/Magnetic Resonance Imaging Confrontation

et al. 1995

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The mechanism of interictal glucose hypometabolism remains unclear, but this abnormality occurs more frequently in temporal lobe epilepsy (TLE) than in other types of partial epilepsy. Therefore temporal hypometabolism has been suggested to reflect mesial temporal sclerosis (MTS). To investigate this, we selected 22 patients with refractory partial epilepsy of mesial temporal lobe origin (MTLE) who had hippocampal atrophy based on magnetic resonance imaging (MRI) volumetric analysis. We then analyzed the metabolic correlates of unilateral hippocampal atrophy. Thirteen temporal regions of interest (ROI) were defined on MRI scans for each individual and then applied to high-resolution FDG-positron emission tomography (PET) images obtained parallel to the long axis of the hippocampus. The most hypometabolic regions were the temporal pole and the hippocampal region. When we analyzed ensembles of temporal regions grouped into related networks, the temporolimbic network, which included the hippocampal region and the temporal pole, was abnormal in 95% of the patients at a 3-SD threshold. PET hypometabolism was highly correlated with the degree of hippocampal atrophy in this network, but not in other parts of the temporal lobe, which were less frequently hypometabolic. These data indicate that hypometabolism is a consequence of MTS in the temporolimbic region but not necessarily in the other parts of the temporal lobe. Our results also suggest that the combination of PET and MRI may facilitate the noninvasive diagnosis of MTLE.

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Section: Pathophysiological and Clinical Implicationssupporting

confidence: 63%

Is Interictal Temporal Hypometabolism Related to Mesial Temporal Sclerosis? A Positron Emission Tomography/Magnetic Resonance Imaging Confrontation

et al. 1995

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“…Unsere bisherigen Ergebnisse bedürfen einer sehr vorsichtigen Interpretation, zumal der Nucleus caudatus lediglich eine kleine Struktur in der Mitte des Gehirns darstellt und Artefakte bei der Regionalisierung derartig kleiner subkortikaler Strukturen durch sog. "partial volume"-Effekte möglich sind, so daß wir die Spezifität der bisherigen Meßergebnisse in Frage stellen müssen, zumal auch die Anzahl der untersuchten Fälle gering ist und zudem methodische Grenzen gegeben sind: die Genauigkeit quantitativer SPECT-Untersuchungen ist aus technischen Gründen limitiert (24, I 18), die Methodik nichtquantitativer oder semiquantitativer Messungen des rCBF ist problematisch (98). Dennoch ist die Fragestellung eine Herausforderung, eine sorgfältige Längsschnittuntersuchung der Risikopersonen wird notwendig sein, um hier weitere Aussagen bez.…”

Section: Pet-und Spect-untersuchungenunclassified

Frühe und präsymptomatische Erkennung der Chorea Huntington

Leblhuber¹

1993

Fortschr Neurol Psychiatr

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This review summarises the techniques for early and presymptomatic testing of Huntington's chorea, a chronic neurodegenerative disorder. Presenting electrodiagnostic, neuroradiographic and neuropsychological measurements, the problem of early detection of this hereditary disorder is discussed. Presently, except for DNA-testing, none of the tests presented can reliably identify symptom-free gene carriers.

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