Cerebral Magnetic Resonance Imaging Findings in Multiple Sclerosis

Reischies, Friedel M.; Baum, K.; Bräu, H.; Hedde, J. P.; Schwindt, Graeme

doi:10.1001/archneur.1988.00520340068014

Cited by 77 publications

(14 citation statements)

References 5 publications

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“…Reischies et al [29] correlated depressive symptoms with MRI findings. They found that subjects with a great er extent of periventricular pathology had slightly more depressive symptoms than other subjects.…”

Section: Neurological Factorsmentioning

confidence: 99%

Depression in Multiple Sclerosis

Patten

Metz

1997

Psychother Psychosom

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Background: An association between multiple sclerosis (MS) and depression has been recognized for several decades and has attracted considerable attention in research. However, there are considerable gaps in the current state of knowledge. In this review, the literature concerned with: (1) the burden of depression in MS; (2) the etiology of depression in MS, and (3) the treatment of depression in MS are critically examined. Method: The literature review utilized Medline (1966–1996), and was supplemented by citations extracted from the papers originally uncovered. Results: Numerous studies have identified elevated depressive symptom scores in MS patients relative to nonclinical and (some) clinical control groups. Furthermore, studies of depressive disorders have clearly documented elevated prevalence rates in MS samples. The literature does not identify any specific pattern of neurological involvement as being consistently associated with depressive symptoms or disorders. Psychosocial risk factors contribute to the etiology of depression in MS, but the relative importance of various risk factors is yet to be determined. A single randomized controlled clinical trial, and additional anecdotal evidence, suggests that antidepressant pharmacotherapy is effective for depressive disorders in MS. Conclusions: Future epidemiological studies should not restrict their evaluation of risk factors to those specific factors that are closely related to the disease process. In particular, future researchers should resist the temptation to focus too exclusively on neuropathology. Biological, psychological and social risk factors are all potentially important. Additional empirical efforts to refine the various treatment approaches would be a welcome addition to this literature.

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Section: Neurological Factorsmentioning

confidence: 99%

Depression in Multiple Sclerosis

Patten

Metz

1997

Psychother Psychosom

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“…There are many controversies in this area of correla tion. Reischies et al [30] support that periventricular (corona radiata) and frontal lesions seem to be the most important lesions for the psychologic symptoms of pa tients with MS suffering from acute exacerbations. Brainin et al [8] reported that all patients with severely impaired memory functions showed bilateral lesions in the medial temporal lobe.…”

Section: Discussionmentioning

confidence: 96%

Correlation of Dementia, Neuropsychological and MRI Findings in Multiple Sclerosis

Tsolaki

Drevelegas²,

Karachristianou³

et al. 1994

Dement Geriatr Cogn Disord

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Twenty patients diagnosed as having multiple sclerosis (MS) were examined by MRI and 9 neuropsychological scales: MMSE, BCRS, RMB, SDMT, BNT, VM, FAS, Benton and Hamilton. The number and distribution of the lesions, and cerebral and corpus callosum atrophy were evaluated by MRI. MR images were generated by a 0.5 Tesla instrument utilizing T1WI, PD and T2WI imaging techniques. The results reveal (1) that patients with MS are impaired in a broad range of cognitive functions but mainly memory is affected; (2) number of lesions in the corona radiata, insula and hippocampus is correlated with cognitive impairment, and (3) enlargement of the IIIrd ventricle is an indicator of memory impairment in MS patients.

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“…Although some investigators have failed to demonstrate an association between the presence of MRI abnormalities and affective symptoms, others have found association between depression and temporal lobe involvement 7,25 lesions in the right parietal region 26 , the left frontal lobe 27 , the left arcuate fasciculus 8,9 or the total lesion load 28 . Additionally, a disconnection between subcortical and cortical areas connected to the limbic system has been proposed 9 .…”

Section: Discussionmentioning

confidence: 99%

Interferon beta-1a-induced depression and suicidal ideation in multiple sclerosis

Lana-Peixoto

Teixeira

Haase

2002

Arq. Neuro-Psiquiatr.

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-Depression and suicide have been reported in association with multiple sclerosis (MS). Some studies show that interferon beta may increase the depression rate. We report a case of depression and suicidal ideation in coincidence with the start of increased doses of interferon beta-1a and their complete reversal following the drug withdrawal. The patient was a 21-year-old man with MS and no past history of affective disorders who was given interferon beta-1a in the dose of 11 µg three times per week. As a new relapse occurred the dose of interferon beta-1a was increased to 22 µg three times a week. The patient then observed increased worry, irritability and a sense of discouragement as well as recurring suicidal thoughts. His mood was rapidly restored following interferon beta-1a withdrawal. This case suggests that patients with MS may develop depression and suicidal thoughts when treated with high doses of interferon beta-1a.KEY WORDS: multiple sclerosis, interferon beta-1a, depression, suicidal ideation. Depressão e idéias suicidas induzidas por interferon beta-1a na esclerose múltiplaRESUMO -Depressão e idéias suicidas são relatados na esclerose múltipla (EM). Alguns estudos demonstram que interferon beta pode aumentar sua freqüência. Relatamos o caso de um jovem de 21 anos com EM, sem história pregressa de distúrbios psiquiátricos, que vinha usando interferon beta-1a na dose de 11 µg três vezes por semana, com boa tolerância. A dose foi aumentada para 22 µg três vezes por semana após um novo surto. O paciente observou o aparecimento de fenômenos depressivos e idéias suicidas coincidindo com o aumento da dose. A suspensão da droga foi acompanhada de desaparecimento completo desses sintomas. Seis meses após a retirada do interferon beta-1a, o paciente se encontra em uso de acetato de glatiramer, não tendo mais apresentado qualquer fenômeno depressivo ou pensamentos suicidas. Este caso sugere que pacientes com EM podem desenvolver depressão e pensamentos suicidas quando tratados com doses elevadas de interferon beta-1a.PALAVRAS-CHAVE: esclerose múltipla, interferon beta-1a, depressão, idéias suicidas.

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Cerebral Magnetic Resonance Imaging Findings in Multiple Sclerosis

Cited by 77 publications

References 5 publications

Depression in Multiple Sclerosis

Depression in Multiple Sclerosis

Correlation of Dementia, Neuropsychological and MRI Findings in Multiple Sclerosis

Interferon beta-1a-induced depression and suicidal ideation in multiple sclerosis

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