2002
DOI: 10.1590/s0004-282x2002000500007
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Interferon beta-1a-induced depression and suicidal ideation in multiple sclerosis

Abstract: -Depression and suicide have been reported in association with multiple sclerosis (MS). Some studies show that interferon beta may increase the depression rate. We report a case of depression and suicidal ideation in coincidence with the start of increased doses of interferon beta-1a and their complete reversal following the drug withdrawal. The patient was a 21-year-old man with MS and no past history of affective disorders who was given interferon beta-1a in the dose of 11 µg three times per week. As a new r… Show more

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Cited by 30 publications
(11 citation statements)
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“…In addition, other serious mental complications are the occurrence of suicidal ideation, suicidal attempts, and completion (5)(6)(7)(8). Case reports worldwide have documented death by suicide in patients receiving cytokines as immune boosting therapy to treat a variety of diseases including melanoma, hepatitis C, HIV infections, and multiple sclerosis (5)(6)(7)(8)(9). While there is a growing recognition of the participation of cytokines in the etiology of mood disorders, their role as pro-suicidal factors has been less studied (10,11).…”
Section: Introductionmentioning
confidence: 99%
“…In addition, other serious mental complications are the occurrence of suicidal ideation, suicidal attempts, and completion (5)(6)(7)(8). Case reports worldwide have documented death by suicide in patients receiving cytokines as immune boosting therapy to treat a variety of diseases including melanoma, hepatitis C, HIV infections, and multiple sclerosis (5)(6)(7)(8)(9). While there is a growing recognition of the participation of cytokines in the etiology of mood disorders, their role as pro-suicidal factors has been less studied (10,11).…”
Section: Introductionmentioning
confidence: 99%
“…Attributing all these changes exclusively to IFN treatment can be difficult because the conditions for which IFNs are prescribed are often themselves associated with neuropsychiatric symptom. 17 In contrast to many studies that show the effect of beta interferon in depression, 40 our study does not bring to light this effect.…”
Section: Mild Moderate Severementioning
confidence: 54%
“…The mechanisms by which interferon beta causes depression are still unclear. A probable mechanism is a change in production of different types of cytokines [9]. An immune dysregulation has been recently associated with mood and cognitive changes in MS [4].…”
Section: Discussionmentioning
confidence: 99%