Cerebral Lactate Metabolism After Traumatic Brain Injury

Patet, Camille; Suys, Tamarah; Carteron, Laurent; Oddo, Mauro

doi:10.1007/s11910-016-0638-5

Cited by 71 publications

(56 citation statements)

References 54 publications

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“…Studies have demonstrated the role of lactate as a neuroprotective energy substrate in brain disorders such as cerebral ischemia (Schurr et al, 2001; Berthet et al, 2009; Horn and Klein, 2013; Castillo et al, 2015) and traumatic brain injury (TBI) (reviewed in Brooks and Martin, 2014; Carpenter et al, 2015; Patet et al, 2016). Early administration of lactate in rat organotypic hippocampal slices after oxygen-glucose deprivation protected against neuronal death, decreased lesion size and showed better neurologic outcomes in a mouse model of middle cerebral artery occlusion (Berthet et al, 2009, 2012).…”

Section: Metabolic Treatments In Alsmentioning

confidence: 99%

Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments

Tefera

Borges

2017

Front. Neurosci.

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease primarily characterized by loss of motor neurons in brain and spinal cord. The death of motor neurons leads to denervation of muscle which in turn causes muscle weakness and paralysis, decreased respiratory function and eventually death. Growing evidence indicates disturbances in energy metabolism in patients with ALS and animal models of ALS, which are likely to contribute to disease progression. Particularly, defects in glucose metabolism and mitochondrial dysfunction limit the availability of ATP to CNS tissues and muscle. Several metabolic approaches improving mitochondrial function have been investigated in vitro and in vivo and showed varying effects in ALS. The effects of metabolic approaches in ALS models encompass delays in onset of motor symptoms, protection of motor neurons and extension of survival, which signifies an important role of metabolism in the pathogenesis of the disease. There is now an urgent need to test metabolic approaches in controlled clinical trials. In addition, more detailed studies to better characterize the abnormalities in energy metabolism in patients with ALS and ALS models are necessary to develop metabolically targeted effective therapies that can slow the progression of the disease and prolong life for patients with ALS.

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Section: Metabolic Treatments In Alsmentioning

confidence: 99%

Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments

Tefera

Borges

2017

Front. Neurosci.

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“…Conventional treatments are not sufficient to block the continual production of toxic and metabolic products, thus the overall effect is not satisfying [4,15]. Ganglioside sodium is a newly developed nerve function protective drug, which can promote the growth of the axon, the formation of synapse and eliminate the toxic and metabolic products.…”

Section: Discussionmentioning

confidence: 99%

Curative effect of ganglioside sodium for adjuvant therapy on acute severe craniocerebral injury

Deng

2016

JAD

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“…In this setting, it is able to guide resuscitation and to a certain extent predict clinical outcome. [6,7] However, the role of lactate in the context of an isolated TBI remains controversial [8][9][10][11][12][13] . Some authors have suggested that elevated serum lactate levels do not correlate with the extent of the cerebral cellular metabolic derangement in these patients, and that the predictive value of serum lactate in TBI is poor.…”

Section: Researchmentioning

confidence: 99%

“…Some authors have suggested that elevated serum lactate levels do not correlate with the extent of the cerebral cellular metabolic derangement in these patients, and that the predictive value of serum lactate in TBI is poor. [8][9][10] Others, however, have shown that the serum lactate level correlates with the severity of TBI. [11,13].…”

Section: Researchmentioning

confidence: 99%

A raised serum lactate level is an independent predictor of in-hospital mortality in patients with isolated cerebral gunshot wounds

et al. 2018

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Cerebral Lactate Metabolism After Traumatic Brain Injury

Cited by 71 publications

References 54 publications

Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments

Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments

Curative effect of ganglioside sodium for adjuvant therapy on acute severe craniocerebral injury

A raised serum lactate level is an independent predictor of in-hospital mortality in patients with isolated cerebral gunshot wounds

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