A raised serum lactate level is an independent predictor of in-hospital mortality in patients with isolated cerebral gunshot wounds

Kong, V Y; Weale, Ross; Laing, G L; Bruce, John; Oosthuizen, George; Sartorius, Benn; Brysiewicz, Petra; Clarke, Damian

doi:10.7196/samj.2018.v108i5.12837

Cited by 5 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown the added prognostic value of lactate value in trauma patients (6,15,16). In addition, several research studies have confirmed that LAR was associated with mortality and the development of multiple organ dysfunction syndrome (MODS) in generalized or pediatric sepsis patients (11-13, 17, 18).…”

Section: Discussionmentioning

confidence: 98%

Lactate Albumin Ratio Is Associated With Mortality in Patients With Moderate to Severe Traumatic Brain Injury

Wang

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

BackgroundTraumatic brain injury (TBI) is a serious public health issue all over the world. This study was designed to evaluate the prognostic value of lactate to albumin ratio (LAR) on patients with moderate to severe TBI.MethodsClinical data of 273 moderate to severe TBI patients hospitalized in West China Hospital between May 2015 and January 2018 were collected. Multivariate logistic regression analyses were used to explore risk factors and construct a prognostic model of in-hospital mortality in this cohort. A receiver operating characteristic (ROC) curve was drawn to evaluate the discriminative ability of this model.ResultsNon-survivors had higher LAR than survivors (1.09 vs. 0.53, p < 0.001). Results of multivariate logistic regression analysis showed that Glasgow Coma Scale (GCS; odds ratio [OR] = 0.743, p = 0.001), blood glucose (OR = 1.132, p = 0.005), LAR (OR = 1.698, p = 0.022), subdural hematoma (SDH; OR = 2.889, p = 0.006), intraparenchymal hemorrhage (IPH; OR = 2.395, p = 0.014), and diffuse axonal injury (DAI; OR = 2.183, p = 0.041) were independent risk factors of in-hospital mortality in included patients. These six factors were utilized to construct the prognostic model. The area under the ROC curve (AUC) values of single lactate, albumin, and LAR were 0.733 (95% Cl; 0.673–0.794), 0.740 (95% Cl; 0.683–0.797), and 0.780 (95% Cl; 0.725–0.835), respectively. The AUC value of the prognostic model was 0.857 (95%Cl; 0.812–0.901), which was higher than that of LAR (Z = 2.1250, p < 0.05).ConclusionsLactate to albumin ratio is a readily available prognostic marker of moderate to severe TBI patients. A prognostic model incorporating LAR is beneficial for clinicians to evaluate possible progression and make treatment decisions in TBI patients.

show abstract

Section: Discussionmentioning

confidence: 98%

Lactate Albumin Ratio Is Associated With Mortality in Patients With Moderate to Severe Traumatic Brain Injury

Wang

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…[17] With a lactate level of 3.3 mmol/L as the cutoff, high lactate levels at admission showed good performance in predicting in-hospital mortality in patients with cerebral gunshot injury. [18] Lee et al LAR at early phase in TBI Secondary injury after TBI, including neuroinflammation, can contribute to disruption of the blood−brain barrier (BBB). [19] Increased vascular permeability and BBB dysfunction after TBI induce leakage of albumin and fluids as well as the transmigration of immune cells.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The association between lactate to albumin ratio and outcomes at early phase in patients with traumatic brain injury

Lee

2023

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

BACKGROUND: The majority of traumatic brain injury (TBI) cases result in death in the early phase; predicting short-term prognosis of affected patients is necessary to prevent this. This study aimed to examine the association between the lactate-to-albumin ratio (LAR) on admission and outcomes in the early phase of TBI. METHODS: This retrospective observational study included patients with TBI who visited our emergency department between January 2018 and December 2020. TBI was considered as an head abbreviated injury scale (AIS) score of 3 or higher and other AIS of 2 or lower. The primary and secondary outcomes were 24-h mortality and massive transfusion (MT), respectively. RESULTS: In total, 460 patients were included. The 24-h mortality was 12.6% (n=28) and MT was performed in 31 (6.7%) patients. In the multivariable analysis, LAR was associated with 24-h mortality (odds ratio [OR], 2.021; 95% confidence interval [CI], 1.301–3.139) and MT (OR, 1.898; 95% CI, 1.288–2.797). The areas under the curve of LAR for 24-h mortality and MT were 0.805 (95% CI, 0.766–0.841) and 0.735 (95% CI, 0.693–0.775), respectively. CONCLUSION: LAR was associated with early-phase outcomes in patients with TBI, including 24-h mortality and MT. LAR may help predict these outcomes within 24 h in patients with TBI.

show abstract

“…Though the lactate serum 0h was above the normal level, it was not correlated with ΔGCS 24h and other outcomes, not consistent with existing research. A study of 102 gunshot patients found that serum lactate concentration was negatively correlated with the GCS scores at admission and positively correlated with in-hospital mortality 10 . A previous study of 213 moderate to severe TBI children revealed that the serum lactate concentration at admission was correlated with less mechanical ventilation time, shorter ICU LOS, hospital LOS, as well as higher mortality 11 .…”

Section: Discussionmentioning

confidence: 99%

Serum lactate monitoring may help to predict neurological function impairment caused by acute metabolism crisis

Liu¹,

Yao²,

Song³

et al. 2023

Sci Rep

View full text Add to dashboard Cite

To investigate the predictive value of serum lactate on neurological function impairment and the possible etiology. In this retrospective study, all the adult patients admitted to ICU more than 24 h after general anesthesia elective neurosurgery from January 2018 to January 2019 were recruited. The data of the serum lactate every 8 h during the 24 h of ICU admission were acquired and analyzed. 169 patients were included in the outcomes analysis. The average serum lactate after ICU admission was 3.7(3.4–4.1) mmol/L, higher than normal, and serum lactate elevated commonly after neurosurgery. The serum lactate at ICU admission (lactateserum0h) was not correlated with the outcomes, whereas the predictive value increased as the monitoring time was extended. The result indicated that lactateserum8h, the lactateserum16h, and the lactateserum24h were correlated with the primary outcome (difference of GCS scores before the surgery and after 24 h of ICU admission (ΔGCS24h) (p < 0.05). The lactateserum16h and the lactateserum 24 h were correlated with all the outcomes except for the hospital LOS. The ROC curve suggested that the lactateserum24h achieved the best predictive value. Patients with serum lactate non-recovered trend after 24 h of ICU stay had decreased GCS scores and vice versa, as indicated by the graph of the dynamic changes in the serum lactate. The predictive value of the serum glucose/serum lactate ratio at ICU admission (G/Lserum) was analyzed, and the result indicated that it was correlated with the ΔGCS24h (p < 0.05), the G/Lserum can predict neurological impairment earlier. Dynamic serum lactate monitoring and the G/Lserum at ICU admission have predict value on neurological function impairment after neurosurgery which might be attributed to ACMC.

show abstract

A raised serum lactate level is an independent predictor of in-hospital mortality in patients with isolated cerebral gunshot wounds

Abstract: CGSWs are associated with significant mortality, and a raised serum lactate level appears to be an independent predictor of in-hospital mortality. It is a potentially useful adjunct in the resuscitation room for identifying patients with a very poor prognosis.

Cited by 5 publications

References 12 publications

Lactate Albumin Ratio Is Associated With Mortality in Patients With Moderate to Severe Traumatic Brain Injury

Lactate Albumin Ratio Is Associated With Mortality in Patients With Moderate to Severe Traumatic Brain Injury

The association between lactate to albumin ratio and outcomes at early phase in patients with traumatic brain injury

Serum lactate monitoring may help to predict neurological function impairment caused by acute metabolism crisis

Contact Info

Product

Resources

About