Cerebral Hemodynamics in Low-Birth-Weight Infants Treated with Phototherapy

Amato, Maurizio; Donati, François; Markus, D.

doi:10.1159/000116673

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…Amato et al suggested that blue light phototherapy did not affect cerebral blood flow velocity in healthy lowbirthweight infants (8) and in term infants (24). However, they only measured V mean during and after phototherapy.…”

Section: Discussionmentioning

confidence: 99%

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The effect of phototherapy on cerebral blood flow velocity in preterm infants

Benders

Bel

Bor³

1998

Acta Paediatrica

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Cerebral blood flow velocity was studied with two‐dimensional/pulsed Doppler ultrasound before, during and after discontinuation of phototherapy in 22 preterm infants (gestational age ≤ 32 weeks), who were treated for a minimum of 12 h with blue‐light phototherapy for non‐haemolytic hyperbilirubinaemia. Before the cerebral blood flow velocity measurements, patency of the ductus arteriosus was diagnosed by Doppler echocardiography. All infants had normal brain ultrasound scans. Mean cerebral blood flow velocity increased significantly after initiation of phototherapy in all infants. Only in “healthy” (non‐ventilated) infants did cerebral blood flow velocity return to pre‐phototherapy values (baseline) after discontinuation of phototherapy, whereas in “unhealthy” (ventilated) infants cerebral blood flow velocity did not return to baseline. In 10 infants the ductus arteriosus reopened during phototherapy. In those infants, mean cerebral blood flow velocity returned to pre‐phototherapy values after 2 h of phototherapy prior to its discontinuation.

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Section: Discussionmentioning

confidence: 99%

“…The course of cerebral blood flow velocity during phototherapy has been previously studied in healthy preterm infants (8). No significant changes were observed.…”

mentioning

confidence: 99%

The effect of phototherapy on cerebral blood flow velocity in preterm infants

Benders

Bel

Bor³

1998

Acta Paediatrica

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“…Cerebral haemodynamics during conventional phototherapy (CPT) were first studied by Amato et al (1991a), who did not report significant changes in cerebral blood flow velocity (CBFV) in healthy preterm infants. However, Benders et al (1998b) found a significant increase in CBFV, both in healthy and 'unhealthy' preterm infants undergoing phototherapy.…”

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confidence: 99%

Effects of phototherapy on cerebral haemodynamics in preterm infants: is fibre‐optic different from conventional phototherapy?

Dani

Bertini

Martelli

et al. 2004

Develop Med Child Neuro

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We hypothesized that conventional phototherapy (CPT) and fibre‐optic phototherapy (FPT) could exert different effects on cerebral blood perfusion. Our aim was to assess this hypothesis in a prospective study of the cerebral haemodynamics in preterm infants. Twenty‐three infants (gestational age <34 weeks) were randomized for CPT (n=12) and for FPT (n=11). Cerebral Doppler ultrasounds were performed on all infants immediately before phototherapy (time 0), 6–12 hours (time 1) and 24–36 hours (time 2) after the start of phototherapy, and 6–12 hours after discontinuing phototherapy (time 3). CPT and FPT were associated with a significant increase of peak‐systolic blood flow velocity and mean blood flow velocity at time 1 and 2, which disappeared at time 3, whereas end‐diastolic blood flow velocity and resistance index were unchanged. No difference was shown between the groups. CPT and FPT were found to exert similar effects on cerebral haemodynamics. Both were associated with an increase of cerebral blood flow velocity which ended when phototherapy was stopped.

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“…Amato and Donati found no effect of phototherapy on cerebral circulation in either preterm [10] or term [11] infants. However, they measured CBFV during and after phototherapy, but not at baseline.…”

Section: Discussionmentioning

confidence: 93%

Comparative Effects of Two Phototherapy Delivery Systems on Cerebral Blood Flow Velocity in Term Neonates

Hammerman

Kaplan

2004

Neonatology

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Background: Phototherapy is an effective and generally safe method of treating neonatal hyperbilirubinemia. However, there is some concern that it may affect cerebral blood flow velocity (CBFV) in newborns with fragile cerebral vasculature. Objectives: To measure and compare the effects of two different phototherapy units, delivering similar irradiance, on CBFVs. Methods: Doppler flow velocities were measured in term infants under fluorescent overhead and fluorescent BiliBed^® phototherapy units, respectively, at baseline, 4 and 24 h of therapy. Results: Peak systolic CBFV increased during treatment in infants treated under overhead phototherapy (n = 18) but not in those treated in BiliBeds^® (n = 12). Conclusions: Different phototherapy delivery modalities can have differential effects on CBFV in term neonates.

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Cerebral Hemodynamics in Low-Birth-Weight Infants Treated with Phototherapy

Cited by 5 publications

References 17 publications

The effect of phototherapy on cerebral blood flow velocity in preterm infants

The effect of phototherapy on cerebral blood flow velocity in preterm infants

Effects of phototherapy on cerebral haemodynamics in preterm infants: is fibre‐optic different from conventional phototherapy?

Comparative Effects of Two Phototherapy Delivery Systems on Cerebral Blood Flow Velocity in Term Neonates

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