Cerebral gliosarcoma, pulmonary adenoid-cystic carcinoma, and pulmonary metastatic gliosarcoma: report of an untreated case

Ojeda, Victor J.; Sterrett, Gregory F.

doi:10.3109/00313028409059108

Cited by 21 publications

(12 citation statements)

References 10 publications

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“…Indeed, Smith et al [17] observed that in 2 cases, the metastatic foci were comprised solely of the sarcomatous component. Other case reports followed with similar findings of mainly sarcomatous elements in metastases [7,18,19,20]. …”

Section: Discussionsupporting

confidence: 51%

Metastatic Gliosarcoma: Cytopathologic Characteristics with Histopathologic Correlations

Lee

Rodríguez²,

Ali³

2016

Acta Cytologica

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Gliosarcoma is a rare variant of glioblastoma multiforme characterized by a biphasic pattern of glial and mesenchymal differentiation. Fine-needle aspiration (FNA) is routinely employed to diagnose a number of primary and secondary malignancies in a variety of clinical settings. Herein, we describe the cytomorphologic features of a gliosarcoma metastatic to an extracranial location accompanied by corresponding clinico-radiologic and histopathologic findings in a 51-year-old man with a posterior mediastinal mass. The cytologic smears displayed a pleomorphic tumor comprised of spindled and epithelioid malignant cells. This case illustrates the ability of FNA to adequately diagnose a rare malignancy in the appropriate clinico-radiologic setting.

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Section: Discussionsupporting

confidence: 51%

Metastatic Gliosarcoma: Cytopathologic Characteristics with Histopathologic Correlations

Lee

Rodríguez²,

Ali³

2016

Acta Cytologica

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“…The development of metastasis from PGS is well established through numerous case reports, and the rate of metastasis found in literature is 11%. 1,[18][19][20][21][22][23][24][25][26][27][28][29][30] Given the relative rarity of PGS, these reports support the clinical experience that PGS may have a greater potential for metastasis than GBM. However, in our series of 20 consecutive patients, there were no documented cases of metastases.…”

Section: Discussionmentioning

confidence: 75%

Clinical characteristics and outcomes for a modern series of primary gliosarcoma patients

Han

Yang

Ahn

et al. 2010

Cancer

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BACKGROUND: Primary gliosarcoma (PGS) is a rare central nervous system tumor with limited experience reported in the literature. In the current study, the authors present a modern series of confirmed PGS cases treated in the era of magnetic resonance imaging (MRI), after the accepted glioblastoma management of resection, radiation, and temozolomide. METHODS: Using a retrospective review, patients with confirmed PGS were identified (1996‐2008). Cases were determined to be PGS by central pathology review using the 2007 World Health Organization criteria. Extensive chart review was performed to gather clinical and pathologic data on these cases. RESULTS: All but 1 patient had undergone a preoperative MRI, with 1 patient receiving a computed tomography scan due to a cardiac pacemaker. A total of 10 patients received radiotherapy with concurrent and adjuvant temozolomide chemotherapy, and 8 patients received radiotherapy alone or in combination with other chemotherapeutic agents. In 2 patients, the history of adjuvant treatment could not be confirmed. The overall median survival was 13.9 months (range, 2.2‐22.9 months). Patients with gliosarcomas resembling meningioma were found to have a significantly prolonged median survival compared with patients harboring gliosarcoma resembling glioblastoma multiforme (16 months vs 9.6 months; P = .011). However, no difference in survival was noted between patients who received concurrent radiotherapy and temozolomide compared with those who did not (10.4 months vs 13.9 months; P = .946). CONCLUSIONS: The results of the current study support previous hypotheses that there are 2 distinct types of PGS. The type mimicking the appearance of a meningioma appears to carry a significantly more favorable prognosis, most likely due to an increased chance at achieving macroscopic total resection. Cancer 2010. © 2010 American Cancer Society.

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“…As metástases sistêmicas relacionadas ao GS apresentam, em sua maioria, os componentes glial e sarcomatoso, mas também podem ocorrer relacionadas unicamente às células sarcomatosas 40 . O tratamento radioterápico, apesar de prolongar a sobrevida dos pacientes com GS, pode facilitar a metaplasia sarcomatosa, com a aquisição de um tipo favorável à disseminação hematogênica, responsável pela prevalência de metástases em pulmão, fígado e linfonodos (Tabela 1) [20][21][22][23]39 . De todo modo, a presença de metástases espinais em casos de gliossarcoma são extremamente raras40, bem como as demais metástases ósseas.…”

Section: Discussionunclassified

“…A taxa dessas metástases em GBM corresponde de 0,2-1,2% [16][17][18] , enquanto que, para o GSa é de 11%, com tendência ao acometimento multi-sistêmico 19 . Os relatos acerca desse assunto indicam que a maioria das metástases extracranianas do GSa ocorrem comumente em pulmões, fígado e linfonodos [20][21][22][23] .…”

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Gliossarcoma Metastático de Longa Sobrevida Pós-Ressecção de Meningioma: relato de caso e revisão da literatura

Souza¹,

Nicoletti²,

Leão³

et al. 2018

jbnc

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RESUMOIntrodução: O gliossarcoma apresenta componentes gliais e sarcomatosos em sua constituição e uma média de sobrevida entre 6 e 14,8 meses. Relato do Caso: Paciente de 32 anos que recebeu, em 2012, o diagnóstico de meningioma e realizou a ressecção cirúrgica. Em 2013, após quadro de cefaleia intensa e crises convulsivas tônico-clônicas, a paciente foi submetida à tomografia computadorizada (TC) e à ressonância magnética (RM), que sugeriram a recidiva do meningioma. Uma nova cirurgia foi efetuada e a análise anatomopatológica confirmou tratar-se de um gliossarcoma, optando-se, portanto, pela radioterapia como conduta adjuvante. Após o tratamento, a paciente recebeu alta e indicação para realizar RM de controle. Em 2015, fraturou o fêmur direito e os exames de imagem indicaram lesão sugestiva de metástase, o que foi confirmado após análise anatomopatológica, instituindo-se tratamento quimioterápico. Mesmo após a conclusão da terapêutica, outros focos de metástase foram confirmados na crista ilíaca, na coluna vertebral e nos pulmões. A paciente, devido ao acometimento sistêmico, veio a óbito 26 meses após o diagnóstico inicial de gliossarcoma. Discussão e Conclusão: Quanto às metástases sistêmicas envolvendo o gliossarcoma, a revisão da literatura evidenciou que as metástases ósseas são incomuns e que, apesar disso, a paciente do caso apresentou sobrevida maior do que a esperada. ABSTRACT Introduction:Gliosarcoma presents glial and sarcomatous components in its constitution and an average survival between 6 and 14.8 months. Case Report: A 32-year-old patient who, in 2012, had meningioma diagnosis and underwent surgical resection. In 2013, after a severe headache and convulsive tonic-clonic seizures, the patient was submitted to computed tomography (CT) and magnetic resonance imaging (MRI), which suggested a relapse of the meningioma. A new surgery was performed and anatomical pathology analysis confirmed gliosarcoma, therefore, radiotherapy was chosen as adjuvant behavior. After treatment, the patient was discharged and indicated to perform control MRI. In 2015, she fractured the right femur and the imaging tests indicated lesions suggestive of metastasis, which was confirmed after anatomical pathology analysis, and chemotherapy treatment was instituted. Even after completion of therapy, other foci of metastasis were confirmed in the iliac crest, spine and lungs. The patient, due to systemic involvement, died 26 months after the initial diagnosis of gliosarcoma. Discussion and Conclusion: Regarding the systemic metastases involving gliosarcoma, a review of the literature has shown that bone metastases are uncommon and that, despite this, our patient had a survival rate higher than expected. IntroduçãoOs meningiomas correspondem de 13 a 26% dos tumores intracranianos 1,2 . São mais comuns em adultos com mais de 60 anos, e sua incidência aumenta com a idade, acometendo duas vezes mais mulheres do que homens 3 . De acordo com a classificação dos tumores do sistema nervoso central (SNC), elaborada pela Organização M...

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Cerebral gliosarcoma, pulmonary adenoid-cystic carcinoma, and pulmonary metastatic gliosarcoma: report of an untreated case

Cited by 21 publications

References 10 publications

Metastatic Gliosarcoma: Cytopathologic Characteristics with Histopathologic Correlations

Metastatic Gliosarcoma: Cytopathologic Characteristics with Histopathologic Correlations

Clinical characteristics and outcomes for a modern series of primary gliosarcoma patients

Gliossarcoma Metastático de Longa Sobrevida Pós-Ressecção de Meningioma: relato de caso e revisão da literatura

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