1986
DOI: 10.3171/jns.1986.64.6.0924
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Cerebral effects of hypocapnia plus nitroglycerin-induced hypotension in dogs

Abstract: This study examined the effect of hypocapnia (PaCO2 20 mm Hg) on cerebral metabolism and the electroencephalogram (EEG) findings in 12 dogs during nitroglycerin (NTG)-induced hypotension. Previous studies suggest that NTG is a more potent cerebral vasodilator than sodium nitroprusside or trimethaphan. It was speculated that combining hypocapnia with NTG-induced hypotension would cause less disturbance of cerebral metabolism and the EEG than the disturbances previously reported when hypocapnia was combined with… Show more

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Cited by 6 publications
(1 citation statement)
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“…Nitroglycerin does not have a direct suppressive effect on the electrical activity of the brain. It may produce EEG changes secondary to systemic hypotension, 23 but this was not the case in our subjects. In addition, the same procedure with healthy subjects did not seem to have any effect.…”
Section: Commentsmentioning
confidence: 53%
“…Nitroglycerin does not have a direct suppressive effect on the electrical activity of the brain. It may produce EEG changes secondary to systemic hypotension, 23 but this was not the case in our subjects. In addition, the same procedure with healthy subjects did not seem to have any effect.…”
Section: Commentsmentioning
confidence: 53%