Cerebral Dysfunctions of Emotion—Cognition Interactions in Adolescent-Onset Schizophrenia

Pauly, Katharina; Seiferth, Nina; Kellermann, Thilo; Backes, Volker; Vloet, Timo D.; Shah, N. Jon; Schneider, Frank; Habel, Ute; Kircher, Tilo

doi:10.1097/chi.0b013e318184ff16

Cited by 57 publications

(58 citation statements)

References 44 publications

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“…To support this notion, Demily et al [30] described an emotional bias towards negative and positive word stimuli in schizophrenic patients but also reported a similar finding in healthy controls. It appears unlikely that, as suggested by the latter authors, a preserved emotional processing in schizophrenia might explain this result, given the large amount of data that evidenced pathological interaction of emotional and cognitive processes [35,[62][63][64] . Consistently, we found that all interference indices in the schizophrenic group were correlated with the emotional distress factor of the PANSS.…”

Section: Discussionmentioning

confidence: 83%

Differential Responses to Emotional Interference in Paranoid Schizophrenia and Bipolar Mania

et al. 2010

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Background: Studies on emotional biases towards threat-related stimuli in schizophrenia and bipolar disorder have provided, so far, inconsistent results. The aim of the present study was to investigate emotional interference in acute schizophrenic and manic patients and its clinical correlates by using a card version of the Emotional Stroop Task designed with neutral, paranoid, depressive and manic words. Methods: Thirty paranoid schizophrenia patients, 30 manic patients and 60 healthy controls were compared on the Emotional Stroop Test. Response times (RT) were collected for each card. Interference indices were calculated by subtracting the RT for the neutral card from the RT for the depressive, paranoid and manic cards. Results: The schizophrenic and manic patient groups showed an increased interference effect when the emotional valence was relating to the disorder-specific psychopathology. In addition, the paranoid interference index correlated with positive symptoms in schizophrenic patients. By contrast, no correlation was evidenced between interference indices and mood symptoms in the manic group. Conclusions: Among schizophrenic patients, paranoid interference might be a state-related emotional abnormality associated with persecutory delusions. In mania, we suggest that emotional biases towards depressive as well as manic information might be trait features of the emotional hyperreactivity involved in the vulnerability to bipolar disorder.

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Section: Discussionmentioning

confidence: 83%

Differential Responses to Emotional Interference in Paranoid Schizophrenia and Bipolar Mania

et al. 2010

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“…A study of adolescent-onset schizophrenia also showed that cerebral dysfunctions of the emotion-cognition interactions are seen at an early age [95] . For example, during a working memory task that evoked negative and neutral emotions, the areas typically associated with working memory performance were found to be hypoactivated in patients with adolescent-onset schizophrenia relative to the control subjects, including the dorsolateral prefrontal and parietal cortex and the anterior cingulate.…”

Section: Related Developmental Researchmentioning

confidence: 98%

“…For example, during a working memory task that evoked negative and neutral emotions, the areas typically associated with working memory performance were found to be hypoactivated in patients with adolescent-onset schizophrenia relative to the control subjects, including the dorsolateral prefrontal and parietal cortex and the anterior cingulate. However, patients with adolescent-onset schizophrenia mainly demonstrated increased activation in key areas of emotional processing, such as the left OFC and medial frontal areas during negative emotion induction [95] . As we reviewed above, the cognitive control of emotion and the emotional influence on cognitive control depend on the integration of several brain regions, such as the PFC, the OFC, the amygdala and other related regions.…”

Section: Related Developmental Researchmentioning

confidence: 99%

The interaction between cognition and emotion

Liu

2009

Chin. Sci. Bull.

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Cognition and emotion have long been thought of as independent systems. However, recent research in the cognitive and neurobiological sciences has shown that the relationship between cognition and emotion is more interdependent than separate. Based on evidence from behavioral and neuroscientific research, researchers have realized that it is necessary to propose a new conceptual framework to describe the relationship between cognition and emotion. In this article, recent research from behavioral, neuroscientific and developmental research on the interaction between cognition and emotion is summarized, and how the interaction of cognition and emotion might affect computer science and artificial intelligence is discussed. It especially focuses on the implications for affective computing. emotion, cognition, interaction, affective computingThe relationship between cognition and emotion has attracted the interest of philosophers and scientists for centuries [1,2] . Starting with Thomas Aquinas (1225-1274) who divided the study of behavior into two broad categories, cognition and affect [3] , cognition and emotion are viewed as separate systems and processes that seldom interact with each other [1] . In the last hundred years, the approach of functional localization has also shaped our conceptual framework of brain function that separates the emotional brain from the cognitive brain [2] . However, the behavioral and neuroscientific data in the past two decades have demonstrated that the notion of functional specialization is problematic. Increasingly more researchers have realized that the processes of cognition and emotion not only interact, but that their neural mechanisms are integrated in the brain so that they jointly contribute to behavior [1,2,[4][5][6] .In the present article, our goal is to summarize the recent behavioral and neuroscientific evidence supporting the interaction of cognition and emotion, and to review the recent accounts on this issue. The main points of the present article are as follows: Firstly, there is an interaction between cognition and emotion not only at the functional level, but also at the neurological level; secondly, the interaction and integration of cognition and emotion is essential to development, and the ability to control emotion at an early age has a significant effect on later development; and finally, the interaction of cognition and emotion may affect many aspects of people's daily activities, including technological innovation. The interaction of cognition and emotion at functional level is reviewed in the first section, the underlying neural regions involved in the interaction are introduced in the second section, and the implications of the interaction between cognition and emotion in daily life are discussed in the last section, especially focusing on the implications for affective computing.

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“…The angular gyrus is structurally (Nierenberg et al 2005) and functionally (Pauly et al 2008) altered in schizophrenia, and is most likely to mediate cognitive aspects of our perceptual matching task, such as monitoring processes. Similarly, the precuneus is implicated in a wide spectrum of highly integrated tasks, including visuo-spatial imagery, episodic memory retrieval and self-processing operations (see Cavanna and Trimble for review), and has been reported to be over-active in patients with schizophrenia during decision making (Paulus et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Influence of Neuregulin1 Genotype on Neural Substrate of Perceptual Matching in Children

et al. 2009

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Adult psychopathology is often rooted early in life and first emerges during childhood and adolescence. However, as most imaging genetic research to date has involved adult participants, little is known about how risk genes affect brain function to influence biological vulnerability in childhood. We examined the impact of neuregulin1 (NRG1), a probable susceptibility gene for schizophrenia and bipolar disorder, on brain function in a sample of 102 healthy 10-12 year old boys including 18 pairs of monozygotic twins, 24 pairs of dizygotic twins and 18 singletons. Each participant performed a perceptual matching task, while brain responses were measured using functional magnetic resonance imaging. Response accuracy and reaction times did not differ as a function of NRG1 genotype; however, individuals with two high-risk alleles showed relatively increased brain activation in a distributed network comprising the precuneus bilaterally, and the left cuneus, middle occipital gyrus, angular gyrus and caudate nucleus. These results indicate that genetic variation in NRG1 significantly affects cortical function during perceptual and monitoring processes in healthy children as young as 10-12 years of age.

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Cerebral Dysfunctions of Emotion—Cognition Interactions in Adolescent-Onset Schizophrenia

Cited by 57 publications

References 44 publications

Differential Responses to Emotional Interference in Paranoid Schizophrenia and Bipolar Mania

Differential Responses to Emotional Interference in Paranoid Schizophrenia and Bipolar Mania

The interaction between cognition and emotion

Influence of Neuregulin1 Genotype on Neural Substrate of Perceptual Matching in Children

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