“…They mainly concerned: 1) absolute light absorption and scattering specific to each tissue, 9,12,13,70 2) the volume of brain tissue exposed to the light source, 3) the resulting signal captured, 13 4) the fact that different Hb species necessitate the use of other wavelengths, 9,70 5) blood volume changes modifying transmission path length, 70 6) possible displacement of the transmitter or receptors on the forehead, 12 7) the influence of extracranial tissue (e.g., muscle) in the readings, 12 8) differences between focal brain saturation and global measurements taken by SjVO 2 under CPB, 9 9) inconsistency in the ratio between arterial/venous blood, 9 and, finally, 10) normal or near-normal saturation levels identified for dead or brain-dead patients. 9,71 This last aspect deserves further discussion because we have observed high values in brain-dead patients from the absence of infrared absorption.…”