Cerebral blood flow velocity in preterm neonates

Ando, Yukinori; Takashima, Sachio; Takeshita, Kenzo

doi:10.1016/s0387-7604(85)80135-2

Cited by 13 publications

(11 citation statements)

References 19 publications

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“…In contrast, measurement of blood flow velocities in the middle cerebral artery of 17 normoxemic, preterm infants and in 51 normal fetuses studied in utero , with both groups studied at 28 weeks gestational age, demonstrated a significantly greater increase in blood flow velocity in the preterm infants over the first 4 weeks of life than in same‐age normal fetuses over the same time frame 51. An increase in some aspects of the blood flow measure (viz., velocity at the end of diastole) was noted prominently even within the first day of life of the preterm infants 51–53…”

Section: Quantitative Brain Imaging Studiesmentioning

confidence: 98%

Brain Imaging Studies of the Anatomical and Functional Consequences of Preterm Birth for Human Brain Development

Peterson

2003

Annals of the New York Academy of Sciences

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Premature birth can have devastating effects on brain development and long-term functional outcome. Rates of psychiatric illness and learning difficulties are high, and intelligence on average is lower than population means. Brain imaging studies of infants born prematurely have demonstrated reduced volumes of parietal and sensorimotor cortical gray matter regions. Studies of school-aged children have demonstrated reduced volumes of these same regions, as well as in temporal and premotor regions, in both gray and white matter. The degrees of these anatomical abnormalities have been shown to correlate with cognitive outcome and with the degree of fetal immaturity at birth. Functional imaging studies have shown that these anatomical abnormalities are associated with severe disturbances in the organization and use of neural systems subserving language, particularly for school-aged children who have low verbal IQs. Animal models suggest that hypoxia-ischemia may be responsible at least in part for some of the anatomical and functional abnormalities. Increasing evidence suggests that a host of mediators for hypoxic-ischemic insults likely contribute to the disturbances in brain development in preterm infants, including increased apoptosis, free-radical formation, glutamatergic excitotoxicity, and alterations in the expression of a large number of genes that regulate brain maturation, particularly those involved in the development of postsynaptic neurons and the stabilization of synapses. The collaboration of both basic neuroscientists and clinical researchers is needed to understand how normal brain development is derailed by preterm birth and to develop effective prevention and early interventions for these often devastating conditions.

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Section: Quantitative Brain Imaging Studiesmentioning

confidence: 98%

Brain Imaging Studies of the Anatomical and Functional Consequences of Preterm Birth for Human Brain Development

Peterson

2003

Annals of the New York Academy of Sciences

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“…13–18 Indomethacin also promotes microvessel maturation in the germinal matrix. 19 Hypoxia, hypercapnia, hypotension, 20 and resulting changes in perfusion are more likely to occur shortly after birth in preterm infants. In addition, more than 50% of all cases of IVH in VLBW infants occur within the first 6–8 hours of life irrespective of gestational age (GA).…”

mentioning

confidence: 99%

Indomethacin Prophylaxis to Prevent Intraventricular Hemorrhage: Association between Incidence and Timing of Drug Administration

Mirza

Laptook

et al. 2013

The Journal of Pediatrics

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Objective To test the hypothesis that administration of indomethacin prophylaxis before 6 hours of life results in a lower incidence of intraventricular hemorrhage (IVH) compared with administration after 6 hours of life, and that the effects of early prophylaxis depend on gestational age (GA) and sex in very low birth weight infants (birth weight <1250 g). Study design Very low birth weight infants admitted to our neonatal intensive care unit between 2003 and 2010 who received indomethacin prophylaxis were analyzed retrospectively. Exclusion criteria included unknown time of indomethacin prophylaxis, death at <12 hours of life, congenital anomalies, and unavailable head ultrasound report. Infants were dichotomized based on the timing of indomethacin prophylaxis (<6 hours or >6 hours of life) to compare incidence of IVH all grades and severe (grade 3–4) IVH. Secondary analyses examined the effects of the time of indomethacin prophylaxis initiation by GA and sex on the incidence of IVH. Results A total of 868 infants (431 males and 437 females) met the criteria for analysis. Indomethacin prophylaxis was given at <6 hours of life in 730 infants and at >6 hours of life to 168 infants. The 2 groups differed with respect to antenatal steroid exposure, GA, outborn prevalence, and pneumothoraces. After multivariate analysis, there were no between-group differences in all-grade or severe IVH. However, females, but not males, treated at <6 hours of life had a lower incidence of severe IVH (P < .05), particularly at lower GAs. Conclusion Prophylactic indomethacin administered before 6 hours of life is not associated with lower incidence of IVH.

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“…Doppler ultrasound has been widely used to study blood flow in the cerebral vessels of preterm babies. [1][2][3][4][5][6][7][8][9][10] Although blood velocity in a peripheral vessel can be accurately measured with Doppler, the size of the vessel cannot. Consequently, flow measures cannot be derived.…”

mentioning

confidence: 99%

Which to measure, systemic or organ blood flow? Middle cerebral artery and superior vena cava flow in very preterm infants

Evans

Kluckow

Simmons

et al. 2002

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Cerebral blood flow velocity in preterm neonates

Cited by 13 publications

References 19 publications

Brain Imaging Studies of the Anatomical and Functional Consequences of Preterm Birth for Human Brain Development

Brain Imaging Studies of the Anatomical and Functional Consequences of Preterm Birth for Human Brain Development

Indomethacin Prophylaxis to Prevent Intraventricular Hemorrhage: Association between Incidence and Timing of Drug Administration

Which to measure, systemic or organ blood flow? Middle cerebral artery and superior vena cava flow in very preterm infants

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