Cerebral beta-endorphin levels in a woman with Prader-Labhart-Willi Syndrome

Pasi, Aurelio; Mehraein, P.; Gramsch, Christian; Jehle, Andreas W.; Briner, J; Häni, M.; Külling, P.; Hauri, R.; Messiha, F.S.

doi:10.1016/0031-9384(89)90313-2

Cited by 3 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Talebizadeh et al , (2005) looked at the expression of ghrelin and peptide YY and their receptors in post-mortem samples of six brain regions (frontal, temporal and visual cortices, and pons, medulla and hypothalamus) in three PWS patients and six control samples finding qualitatively similar expression in all samples, although a quantitative (and preliminary) analysis of expression levels was only carried out for the 1 y old PWS and control samples suggesting potential quantitative growth hormone receptor difference [ 71 ]. Finally, Pasi et al , (1989) [ 69 ] reported no clear alterations of beta-endorphin levels pertaining to PWS in a single case post-mortem study of a young female adult with PWS, despite literature suggesting an association between beta-endorphin increases in CSF and appetite, pain insensitivity and thermoregulation difficulties [ 69 ].…”

Section: Neurochemical Investigations and Neuroanatomy At The Cellmentioning

confidence: 99%

Puzzle Pieces: Neural Structure and Function in Prader-Willi Syndrome

Manning

Holland

2015

Diseases

View full text Add to dashboard Cite

Prader-Willi syndrome (PWS) is a neurodevelopmental disorder of genomic imprinting, presenting with a behavioural phenotype encompassing hyperphagia, intellectual disability, social and behavioural difficulties, and propensity to psychiatric illness. Research has tended to focus on the cognitive and behavioural investigation of these features, and, with the exception of eating behaviour, the neural physiology is currently less well understood. A systematic review was undertaken to explore findings relating to neural structure and function in PWS, using search terms designed to encompass all published articles concerning both in vivo and post-mortem studies of neural structure and function in PWS. This supported the general paucity of research in this area, with many articles reporting case studies and qualitative descriptions or focusing solely on the overeating behaviour, although a number of systematic investigations were also identified. Research to date implicates a combination of subcortical and higher order structures in PWS, including those involved in processing reward, motivation, affect and higher order cognitive functions, with both anatomical and functional investigations indicating abnormalities. It appears likely that PWS involves aberrant activity across distributed neural networks. The characterisation of neural structure and function warrants both replication and further systematic study.

show abstract

Section: Neurochemical Investigations and Neuroanatomy At The Cellmentioning

confidence: 99%