Cerebello–thalamo–cerebral connections in pediatric brain tumor patients: Impact on working memory

Law, Nicole; Bouffet, Éric; Laughlin, Suzanne; Laperrière, Normand; Brière, Marie-Eve; Strother, Douglas; McConnell, Dina; Hukin, Juliette; Fryer, Christopher; Rockel, Conrad; Dickson, Jolynn; Mabbott, Donald

doi:10.1016/j.neuroimage.2011.03.065

Cited by 103 publications

(122 citation statements)

References 77 publications

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“…21,56,57 Nevertheless, the present connectivity findings must be cautiously interpreted until their specific neuroanatomical substrates can be elucidated. Third, compared with recent cerebellar connectivity studies using higher angular resolution diffusion imaging 94 and probabilistic tractography, [95][96][97] the method we used in this study is based on the conventional deterministic approach using a streamline technique. 63 Therefore, this study has a potential limitation in being able to identify the deep intrapathways (eg, via dentate nucleus) within cerebellar connections.…”

Section: Methodological Issuesmentioning

confidence: 99%

Disrupted Modular Architecture of Cerebellum in Schizophrenia: A Graph Theoretic Analysis

Kim

Kent

Bolbecker

et al. 2014

Schizophrenia Bulletin

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Recent studies of schizophrenia have revealed cognitive and memory deficits that are accompanied by disruptions of neuronal connectivity in cortical and subcortical brain regions. More recently, alterations of topological organization of structural networks in schizophrenia are also being identified using graph theoretical analysis. However, the role of the cerebellum in this network structure remains largely unknown. In this study, global network measures obtained from diffusion tensor imaging were computed in the cerebella of 25 patients with schizophrenia and 36 healthy volunteers. While cerebellar global network characteristics were slightly altered in schizophrenia patients compared with healthy controls, the patients showed a retained small-world network organization. The modular architecture, however, was changed mainly in crus II. Furthermore, schizophrenia patients had reduced correlations between modularity and microstructural integrity, as measured by fractional anisotropy (FA) in lobules I-IV and X. Finally, FA alterations were significantly correlated with the Positive and Negative Syndrome Scale symptom scores in schizophrenia patients. Taken together, our data suggest that schizophrenia patients have altered network architecture in the cerebellum with reduced local microstructural connectivity and that cerebellar structural abnormalities are associated symptoms of the disorder.

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Section: Methodological Issuesmentioning

confidence: 99%

Disrupted Modular Architecture of Cerebellum in Schizophrenia: A Graph Theoretic Analysis

Kim

Kent

Bolbecker

et al. 2014

Schizophrenia Bulletin

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“…Diffuse and nonfocal increases in ADC have also been implicated in those treated with high doses of cranial radiation (Law et al 2011;Mabbott et al 2005). It is clear from these studies that white matter integrity is compromised in a wide range of frontal and posterior white matter projections.…”

Section: Diffusion Tensor Imaging and White Matter Integritymentioning

confidence: 96%

“…In general, studies have observed decreased FA values in several white matter networks including frontal and parietal periventricular white matter, corpus callosum, corona radiata, right inferior fronto-occipital fasciculus, anterior and posterior limbs of the internal capsule, inferior frontal white matter, high frontal white matter, pons, medulla oblongata, and cerebello-thalamo-cerebral tracts (Aukema et al 2009;Khong et al 2003;Khong et al 2005;Law et al 2011;Leung et al 2004;Mabbott et al 2005). …”

Section: Diffusion Tensor Imaging and White Matter Integritymentioning

confidence: 98%

“…Future studies will need to carefully evaluate the impact of white matter abnormalities and their relationship to academic skill development. Various executive functioning tasks have also been implicated in white matter abnormalities including RD and shifting attention, cognitive flexibility, and working memory (Brinkman et al 2012;Law et al 2011). Taken together, there does not appear to be a clear pattern of white matter abnormalities and associated neurocognitive relationships in pediatric brain tumors.…”

Section: Diffusion Tensor Imaging and Functionmentioning

confidence: 99%

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Effects of Cranial Radiation on Structural and Functional Brain Development in Pediatric Brain Tumors

Bledsoe

2015

J Pediatr Neuropsychol

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There is emerging research connecting neuroimaging correlates and neurocognitive functioning in pediatric brain tumors. Current work has attempted to measure the impact of cranial radiation on brain and behavior outcomes with the goal of better understanding the mechanisms of treatment late effects. While critical for treatment, cranial radiation can have a substantial impact on the developing brain and on neuropsychological development. This paper provides a critical review of the most recent empirical structural and functional neuroimaging research evaluating the impact of cranial radiation on neuropsychological functioning in pediatric brain tumors. The importance in study methodology, potential outcome moderating variables, limitations, and future directions is discussed.

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“…Alguns trabalhos têm feito alusão ao papel desempenhado pelo cerebelo em funções cognitivas não motoras, tendo sido observados prejuízos neuropsicológicos de caráter pré-frontal em pacientes submetidos à ressecção cirúrgica de lesões cerebelares benignas. Estes estudos sugerem que as conexões entre o cerebelo e o córtex pré-frontal dorsolateral são prejudicadas por tumores de FP e pelo procedimento cirúrgico invasivo, interferindo, assim, no desenvolvimento das funções executivas, da memória operacional e da atenção (Budisavlyevic & Rammani, 2012;Law, Bouffet & Laughlin, 2011;Stargatt, Anderson & Rosenfeld, 2002;Riva & Giorgi, 2000;Varela, Liakopoulou & Alexiou, 2011).…”

Section: Cirurgiaunclassified

Neuropsicologia e Oncologia Pediátrica: um diálogo em emergência

Hazin¹,

Garcia²,

Gomes³

et al. 2016

Inter. Psicol.

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RESUMODados do INCA estimam que anualmente cerca de 11.530 casos de neoplasias são diagnosticados em crianças e adolescentes. O aumento do número de sobreviventes vem crescendo, junto com as sequelas cognitivas decorrentes da doença e de seu tratamento. Nesse sentido, o presente artigo discute acerca da pertinência do estabelecimento de diálogo entre a neuropsicologia e a oncologia. O artigo aborda os dois subtipos de câncer mais comuns na infância e adolescência: os tumores de fossa posterior e a leucemia linfoide aguda. A discussão será ilustrada com resultados oriundos de dois estudos distintos realizados em serviços públicos de referência no tratamento do câncer pediátrico na Região Nordeste do Brasil.Palavras-chave: neuropsicologia; oncologia; desenvolvimento. ABSTRACT Neuropsychology and Oncology: an emerging dialogueINCA data estimate that around 11.530 cases of neoplasias are diagnosed yearly among children and teenagers. On the other hand, the number of survivors of these diseases has been increasing, together with cognitive sequels related to the illness and its treatment. In this context, the present paper discusses the need of establishing a dialogue between neuropsychology and oncology. Two of the most common types of cancer occurring during childhood and adolescence are addressed: tumors of posterior fossa and acute lymphoblastic leukemia. Data issued from two empirical studies developed in North-East Brazilian region public health services for pediatric cancer treatment will illustrate the discussion mentioned above.

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Cerebello–thalamo–cerebral connections in pediatric brain tumor patients: Impact on working memory

Cited by 103 publications

References 77 publications

Disrupted Modular Architecture of Cerebellum in Schizophrenia: A Graph Theoretic Analysis

Disrupted Modular Architecture of Cerebellum in Schizophrenia: A Graph Theoretic Analysis

Effects of Cranial Radiation on Structural and Functional Brain Development in Pediatric Brain Tumors

Neuropsicologia e Oncologia Pediátrica: um diálogo em emergência

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