Cerebellar Volumes in Pediatric Maltreatment-Related Posttraumatic Stress Disorder

Abstract

The results support cerebellar volume differences in maltreated children and adolescents with PTSD. Further studies are warranted.

Cannabinoid receptor expression and phosphorylation are differentially regulated between male and female cerebellum and brain stem after repeated stress: Implication for PTSD and drug abuse

“…ical symptoms in pediatric maltreatment-related PTSD. The PTSD subjects had significantly reduced volume in both the left and the right hemispheres and in total cerebellum volume [11]. These studies implicate a link between stress-induced apoptosis and cerebellum atrophy in PTSD although the exact causative factors and the time course of the atrophy remain to be established.…”

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

“…43 The same research group, which was the first to examine the cerebellum by a manual method, later detected a reduction of cerebellar volume in children and adolescents with PTSD. 44 In view of previous findings of an increased corticotropin concentration in adults and children with PTSD, 45 a study on a pediatric population focused on the pituitary gland but the authors did not find any significant difference between patients and controls. 46 In general, the diversity of traumatic events, the chronicity of PTSD and the presence of co-morbidities contribute to the heterogeneity of population samples, impairing the comparability and generalization of the results.…”

Cerebellar volume in patients with dementia

“…The cisterna magna and transverse sinus were excluded. 27 The last slice included was the one at which the cerebellum was no longer distinguishable from the transverse sinus or had disappeared. The measurement of the vermis began at the slice where the anterior and/or inferior posterior lobes appeared.…”

“…Measurements were made until the vermis was no longer visible. 27 3) Reproducibility To evaluate the intra-rater reproducibility, the same rater repeated the TIV, brain, temporal lobe, and cerebellar measurements twice, at least a week apart, for 10 randomly selected subjects. Inter-rater reproducibility was assessed by two investigators, blinded in regard to the patient's details, who measured TIV and brain volumes for five randomly selected subjects.…”