Cerebellar metabolite alterations detected in vivo by proton MR spectroscopy

Macrì, Monica; Garreffa, Girolamo; Giove, Federico; Ambrosini, Anna; Guardati, Manuela; Pierelli, Francesco; Schoenen, Jean; Colonnese, Claudio; Maraviglia, B.

doi:10.1016/j.mri.2003.08.021

Cited by 16 publications

(25 citation statements)

References 22 publications

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“…A reduced NAA concentration was also found in several other brain regions of MwA patients without stimulation [22,23,25]. In other than occipital regions, significant differences for other metabolites such as myo-inositol (Ins), total creatine (tCr), choline (Cho) and glutamate/glutamine (Glx) have been found between migraineurs and controls [22,23,26,27].…”

Section: Introductionmentioning

confidence: 84%

1H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique

Reyngoudt

Deene

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et al. 2010

Magn Reson Mater Phy

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Section: Introductionmentioning

confidence: 84%

1H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique

Reyngoudt

Deene

Descamps

et al. 2010

Magn Reson Mater Phy

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“…A single study reports a decreased Cho level in the cerebellum of MwA patients, suggesting a variation in membrane turnover and/or composition (48).…”

Section: Chomentioning

confidence: 99%

“…In quite a few other studies, however, no information about the medication history of migraine patients is given (15,17,19,20,27,28,37,48,54). Furthermore, in the earliest MRS-studies (5-7) as well as in Prescot et al (45), a small minority of patients studied ictally were taking medication for migraine prophylaxis.…”

Section: Prophylaxis: Yes or No?mentioning

confidence: 99%

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Magnetic resonance spectroscopy in migraine: What have we learned so far?

2012

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Objective: To summarize and evaluate proton (1H) and phosphorus (31P) magnetic resonance spectroscopy (MRS) findings in migraine. Methods: A thorough review of 1H and/or 31P-MRS studies in any form of migraine published up to September 2011. Results: Some findings were consistent in all studies, such as a lack of ictal/interictal brain pH change and a disturbed energy metabolism, the latter of which is reflected in a drop in phosphocreatine content, both in the resting brain and in muscle following exercise. In a recent interictal study ATP was found to be significantly decreased in the occipital lobe of migraine with aura patients, reinforcing the concept of a mitochondrial component to the migraine threshold, at least in a subgroup of patients. In several studies a correlation between the extent of the energy disturbance and the clinical phenotype severity was apparent. Less consistent but still congruent with a disturbed energy metabolism is an observed lactate increase in the occipital cortex of several migraine subtypes (MwA, migraine with prolonged aura). No increases in brain glutamate levels were found. Conclusion: The combined abnormalities found in MRS studies imply a mitochondrial component in migraine neurobiology. This could be due to a primary mitochondrial dysfunction or be secondary to, for example, alterations in brain excitability. The extent of variation in the data can be attributed to both the variable clinical inclusion criteria used and the variation in applied methodology. Therefore it is necessary to continue to optimize MRS methodology to gain further insights, especially concerning lactate and glutamate.

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“…MRS is a technique to measure the chemical shift in accordance with a translated radiofrequency pulse and MRS can be used to analyze the structure, molecular elements and the state of the test object. Consequently, MRS can help obtain useful non-invasive in vivo information, and it is a preferred modality in clinical medicine for human (Baik et al, 2003;Bertolino et al, 1998;Guerrinia et al, 2002;Macri et al, 2003;Mountford et al, 1986;Tedeschi et al, 2002) and animal models (Blackband and Stoskopf, 1990;Botnar et al, 2004;Choi et al, 2005;Dedeoglua et al, 2004;Rudin et al, 1995;Yancy et al, 2005). In order to evaluate the performance of an MR system, an MR phantom has been developed to accurately analyze errors of MR systems.…”

Section: Introductionmentioning

confidence: 99%