Cerebellar hyperactivity during smooth pursuit eye movements in bipolar disorder

Martin, Laura F.; Olincy, Ann; Ross, Randal G.; Du, Yiping P.; Singel, Debra; Shatti, Shireen; Tregellas, Jason R.

doi:10.1016/j.jpsychires.2010.09.015

Cited by 12 publications

(8 citation statements)

References 90 publications

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“…Consistent with altered emotional regulation, we observed T1ρ differences in lobule VII of participants with mania and lobules VI and VII of participants in the euthymic and depressed states. In addition, the euthymic and depressed groups had an altered T1ρ signal in aspects of lobules IV and/or V, which suggests differences in motor control sites as well and supports previous observations of altered cerebellar activity during motor tasks in bipolar disorder …”

Section: Discussionsupporting

confidence: 88%

Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping

et al. 2018

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Section: Discussionsupporting

confidence: 88%

Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping

et al. 2018

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“…In addition, these disorders do not produce BOLD signal abnormalities comparable to those reported here. 78,[94][95][96][97][98] Therefore, our results indicate that neither neuropsychological measures nor measures of predictive visual tracking eye movements accurately discriminated individual symptomatic chronic mTBI subjects from controls. These negative results were obtained concurrently with the promising accuracy of classification of chronic mTBI subjects observed using BOLD-fMRI measures in regions of the white matter.…”

Section: Poor Accuracy Of Behavioral Tests In Identifying Individual mentioning

confidence: 55%

Abnormal White Matter Blood-Oxygen-Level–Dependent Signals in Chronic Mild Traumatic Brain Injury

Astafiev

Shulman

Metcalf

et al. 2015

Journal of Neurotrauma

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Concussion, or mild traumatic brain injury (mTBI), can cause persistent behavioral symptoms and cognitive impairment, but it is unclear if this condition is associated with detectable structural or functional brain changes. At two sites, chronic mTBI human subjects with persistent post-concussive symptoms (three months to five years after injury) and age-and education-matched healthy human control subjects underwent extensive neuropsychological and visual tracking eye movement tests. At one site, patients and controls also performed the visual tracking tasks while blood-oxygen-leveldependent (BOLD) signals were measured with functional magnetic resonance imaging. Although neither neuropsychological nor visual tracking measures distinguished patients from controls at the level of individual subjects, abnormal BOLD signals were reliably detected in patients. The most consistent changes were localized in white matter regions: anterior internal capsule and superior longitudinal fasciculus. In contrast, BOLD signals were normal in cortical regions, such as the frontal eye field and intraparietal sulcus, that mediate oculomotor and attention functions necessary for visual tracking. The abnormal BOLD signals accurately differentiated chronic mTBI patients from healthy controls at the single-subject level, although they did not correlate with symptoms or neuropsychological performance. We conclude that subjects with persistent post-concussive symptoms can be identified years after their TBI using fMRI and an eye movement task despite showing normal structural MRI and DTI.

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“…Other evidence supports the fact that the cerebellum mediates the activity of other brain areas involved in the control of eye movements, specifically through the vermis, focculi, paraflocculi, and deep cerebellar nuclei 75,76. A study utilizing functional magnetic resonance evaluated the performance of bipolar subjects during SPEM tasks 77. The research identified a greater hemodynamic in the cerebellar vermis of the bipolar subjects (in specific patients with symptoms of depression) than in healthy subjects.…”

Section: Discussionmentioning

confidence: 92%

“…The research identified a greater hemodynamic in the cerebellar vermis of the bipolar subjects (in specific patients with symptoms of depression) than in healthy subjects. The authors suggested that this may imply a cerebellar involvement in BD 77. Functional magnetic resonance studies also provide evidence that the cerebellar hemispheres play a significant role in smooth pursuit and SEM 75.…”

Section: Discussionmentioning

confidence: 96%

Saccadic eye movement applications for psychiatric disorders

Bittencourt¹,

Velasques²,

Teixeira³

et al. 2013

NDT

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ObjectiveThe study presented here analyzed the patterns of relationship between oculomotor performance and psychopathology, focusing on depression, bipolar disorder, schizophrenia, attention-deficit hyperactivity disorder, and anxiety disorder.MethodsScientific articles published from 1967 to 2013 in the PubMed/Medline, ISI Web of Knowledge, Cochrane, and SciELO databases were reviewed.ResultsSaccadic eye movement appears to be heavily involved in psychiatric diseases covered in this review via a direct mechanism. The changes seen in the execution of eye movement tasks in patients with psychopathologies of various studies confirm that eye movement is associated with the cognitive and motor system.ConclusionSaccadic eye movement changes appear to be heavily involved in the psychiatric disorders covered in this review and may be considered a possible marker of some disorders. The few existing studies that approach the topic demonstrate a need to improve the experimental paradigms, as well as the methods of analysis. Most of them report behavioral variables (latency/reaction time), though electrophysiological measures are absent.

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Cerebellar hyperactivity during smooth pursuit eye movements in bipolar disorder

Cited by 12 publications

References 90 publications

Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping

Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping

Abnormal White Matter Blood-Oxygen-Level–Dependent Signals in Chronic Mild Traumatic Brain Injury

Saccadic eye movement applications for psychiatric disorders

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