Cerebellar Cognitive Affective Syndrome in a Case of Cerebrotendinous Xanthomatosis

Ghosh, Ritwik; León-Ruiz, Moisés; Sardar, Sona Singh; Naga, Dinobandhu; Ghosh, Tapas; Dutta, Souvik; Benito‐León, Julián

doi:10.1007/s12311-022-01421-4

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…In these studies [8,9], clinically relevant deficits in executive function, visuospatial performance, linguistic processing, and mood dysregulation were reported in patients with cerebellum lesions. These findings have been replicated in patients belonging to different ages and pathologiescongenital, hereditary, injurious, or degenerative [5,10] Event-related potentials (ERP) have often been used to assess cognitive impairment [11]. These evoked potentials depend on the subject's selective attention to external stimuli [11].…”

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confidence: 90%

P300 Wave Alterations and Cognitive Impairment in Cerebellum Lesions

et al. 2023

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Patients with cognitive deficits have a prolonged latency and reduced amplitude of the P300 wave. However, no study has correlated P300 wave alterations with the cognitive performance of patients with cerebellar lesions. We aimed to determine if the cognitive status of these patients was associated with P300 wave alterations. We recruited 30 patients with cerebellar lesions from the wards of the N.R.S. Medical College, Kolkata, in West Bengal (India). The Kolkata Cognitive Screening Battery tasks and the Frontal Assessment Battery (FAB) were used to assess the cognitive status and the International Cooperative Ataxia Rating Scale (ICARS) for cerebellar signs. We compared the results with the normative data of the Indian population. Patients had P300 wave alterations with a significant increase in latency and a non-significant trend in amplitude. In a multivariate model, P300 wave latency was positively associated with the ICARS kinetic subscale (p = 0.005) and age (p = 0.009), regardless of sex and years of education. In the model that included cognitive variables, P300 wave latency was negatively associated with performance in phonemic fluency (p = 0.035) and construction (p = 0.009). Furthermore, P300 wave amplitude was positively associated with the FAB total score (p < 0.001). In closing, patients with cerebellar lesions had an increase in latency and a decrease in the amplitude of the P300 wave. These P300 wave alterations were also associated with worse cognitive performance and some of the subscales of the ICARS, reinforcing that the cerebellum has motor, cognitive, and affective functions.

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Section: Introductionmentioning

confidence: 90%

P300 Wave Alterations and Cognitive Impairment in Cerebellum Lesions

et al. 2023

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“…These ndings have been replicated at different ages and pathologiescongenital, hereditary, injurious, or degenerative. [5,10] Event-related potentials (ERP) have often been used to assess cognitive impairment [11]. These evoked potentials depend on the subject's selective attention to external stimuli.…”

Section: Introductionmentioning

confidence: 99%

P300 wave alterations are associated with worse cognitive performance in cerebellum lesions

Nanda,

Lapeña-Motilva,

Misra

et al. 2023

Journal of the Neurological Sciences

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P300 wave alterations are associated with worse cognitive performance in cerebellum lesions

Nanda¹,

Lapeña-Motilva

Misra³

et al. 2022

Preprint

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Background The P300 wave shows a prolonged latency and reduced amplitude in patients with cognitive deficits. However, no study correlated P300 wave changes with the cognitive performance of patients with cerebellar lesions. We aimed to determine if the cognitive status of these patients is associated with P300 wave alterations. Methods We recruited 30 patients with cerebellar lesions from the wards of the N.R.S. Medical College, Kolkata, in West Bengal (India). The Kolkata Cognitive Screening Battery tasks and the Frontal Assessment Battery were used to assess the cognitive status and the International Cooperative Ataxia Rating Scale for cerebellar signs. We compared the results with the normative data of the Indian population. Results Patients had P300 wave alterations, with a significant increase in latency and a non-significant trend in amplitude. In a multivariate model, P300 wave latency was positively associated with the ICARS kinetic subscale (p = 0.005) and age (p = 0.009), regardless of sex and years of education. In the model that included cognitive variables, P300 wave latency was negatively associated with performance in phonemic fluency (p = 0.035) and construction (p = 0.009). Furthermore, P300 wave amplitude was positively associated with the FAB total score (p < 0.001). Conclusion Patients with cerebellar damage had an increase in latency and a decrease in the amplitude of the P300 wave. These P300 wave alterations were also associated with worse cognitive performance and some of the subscales of ICARS, reinforcing that the cerebellum has both motor and cognitive and affective functions.

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Cerebellar Cognitive Affective Syndrome in a Case of Cerebrotendinous Xanthomatosis

Cited by 3 publications

References 10 publications

P300 Wave Alterations and Cognitive Impairment in Cerebellum Lesions

P300 Wave Alterations and Cognitive Impairment in Cerebellum Lesions

P300 wave alterations are associated with worse cognitive performance in cerebellum lesions

P300 wave alterations are associated with worse cognitive performance in cerebellum lesions

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