P300 wave alterations are associated with worse cognitive performance in cerebellum lesions

Abstract

Background The P300 wave shows a prolonged latency and reduced amplitude in patients with cognitive deficits. However, no study correlated P300 wave changes with the cognitive performance of patients with cerebellar lesions. We aimed to determine if the cognitive status of these patients is associated with P300 wave alterations. Methods We recruited 30 patients with cerebellar lesions from the wards of the N.R.S. Medical College, Kolkata, in West Bengal (India). The Kolkata Cognitive Screening Battery tasks and the Frontal Assessment Battery were used to assess the cognitive status and the International Cooperative Ataxia Rating Scale for cerebellar signs. We compared the results with the normative data of the Indian population. Results Patients had P300 wave alterations, with a significant increase in latency and a non-significant trend in amplitude. In a multivariate model, P300 wave latency was positively associated with the ICARS kinetic subscale (p = 0.005) and age (p = 0.009), regardless of sex and years of education. In the model that included cognitive variables, P300 wave latency was negatively associated with performance in phonemic fluency (p = 0.035) and construction (p = 0.009). Furthermore, P300 wave amplitude was positively associated with the FAB total score (p < 0.001). Conclusion Patients with cerebellar damage had an increase in latency and a decrease in the amplitude of the P300 wave. These P300 wave alterations were also associated with worse cognitive performance and some of the subscales of ICARS, reinforcing that the cerebellum has both motor and cognitive and affective functions.