CERASPECT: a brain-dedicated SPECT system. Performance evaluation and comparison with the rotating gamma camera

Zito, Felicia; Savi, A.; Fazio, Ferruccio

doi:10.1088/0031-9155/38/10/005

Cited by 16 publications

(5 citation statements)

References 10 publications

(2 reference statements)

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“…Among the earliest systems, the Mark IV system may be considered one of the pioneers in this category, capable of imaging the brain using radionuclide imaging agents available at that time [11]. Neurocam (GE-CGR, Buc, France) [12], a stationary hemispherical SPECT imager built at the University of Arizona [13], and CERASPECT [14] were other examples of dedicated brain SPECT scanners with fully stationary or pseudo-stationary gantries. More recently, other systems have been developed as well [10,[15][16][17].…”

mentioning

confidence: 99%

Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging

Zeraatkar

Kalluri

Auer

et al. 2020

IEEE Trans. Med. Imaging

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We designed a dedicated multi-detector multipinhole brain SPECT scanner to generate images of higher quality compared to general-purpose systems. The system, AdaptiSPECT-C, is intended to adapt its sensitivity-resolution trade-off by varying its aperture configurations allowing both high-sensitivity dynamic and high-spatial-resolution static imaging. The current system design consists of 23 detector heads arranged in a truncated spherical geometry. In this work, we investigated the axial and angular sampling capability of the current stationary system design. Two data acquisition schemes using limited rotation of the gantry and two others using axial translation of the imaging bed were also evaluated concerning their impact on image quality through improved sampling. Increasing both angular and axial sampling in the current prototype system resulted in quantitative improvements in image quality metrics and qualitative appearance of the images as determined in studies with specifically selected phantoms. Visual improvements for the brain phantoms with clinical distributions were less pronounced but presented quantitative improvements in the fidelity (normalized root-mean-square error (NRMSE)) and striatal specific binding ratio (SBR) for a dopamine transporter (DAT) distribution, and in NRMSE and activity recovery for a brain perfusion distribution. More pronounced improvements with increased sampling were seen in contrast recovery coefficient, bias, and coefficient of variation for a lesion in the brain perfusion distribution. The negligible impact of the most cranial ring of detectors on axial sampling, but its significant impact on sensitivity and angular sampling in the cranial portion of the imaging volume-of-interest were also determined. Index Terms-AdaptiSPECT-C, angular and axial sampling, SPECT, pinhole, multi-pinhole. I. INTRODUCTION B RAIN SPECT imaging has been of interest for many clinical applications in neuroimaging including Alzheimer's, Parkinson's, and Huntington's diseases,

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confidence: 99%

Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging

Zeraatkar

Kalluri

Auer

et al. 2020

IEEE Trans. Med. Imaging

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“…The novel collimator geometry for stationary SPECT imaging we propose is inspired by the CERASPECT system (Zito et al 1993), a rotating brain-SPECT system, with the difference here being that our collimator is stationary. It consists of a collimator body of heavy metal surrounding the field-of-view (FOV), which is surrounded by a ring of gamma-ray detectors.…”

Section: The Conceptmentioning

confidence: 99%

Parallel-hole collimator concept for stationary SPECT imaging

Pato

Vandenberghe²,

Zedda³

et al. 2015

Phys. Med. Biol.

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Parallel-hole SPECT collimators have traditionally been manufactured by stacking sheets of lead foil or by casting. These techniques significantly restrict our options in terms of collimator geometry. However, recent developments in metal additive manufacturing are making novel collimator designs possible, giving rise to new opportunities in SPECT imaging. In this paper we propose an innovative type of collimator for stationary SPECT, using parallel-holes whose collimation direction depends on their axial position. Its main advantage compared to current stationary SPECT systems (which are based on pinholes) is that, using only axial bed translations, we can achieve complete angular sampling of an increased portion of the transaxial area of the collimator bore. This allows the system to be much more compact than current stationary SPECT systems that image objects of the same size. We describe three possible designs, for full-body, brain and small-animal imaging, respectively, and test their feasibility using simulations. The system modeling method is validated against realistic Monte Carlo simulations, and then used in the evaluation of the systems' performances and reconstructions. The simulations show that the system is able to reconstruct objects occupying the predicted field of view ([Formula: see text] of the transaxial area of the bore) without sampling artifacts. In particular, we perform reconstructions from noisy projection data obtained for an activity and scanning time similar to standard protocols for the three applications, and the resulting images indicate the possibility of using the proposed systems in practice.

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“…A full-ring multi-pinhole system provided 3.3 mm resolution at 0.017% sensitivity or 8 mm resolution at 0.102% sensitivity [5]. An annular SPECT system consisting of a three-segment parallel-beam rotating collimator within a stationary annular crystal (CeraSPECT™) provided 8.3 mm resolution and 0.022% sensitivity at the central axis [6, 7]. The collimators of this system were replaced with variable focusing collimators (SensOgrade™) to further increase the sensitivity (by a factor of 1.4–2) [8].…”

Section: Introductionmentioning

confidence: 99%

Simulations of a Multipinhole SPECT Collimator for Clinical Dopamine Transporter (DAT) Imaging

Könik

Beenhouwer

Mukherjee

et al. 2018

IEEE Trans. Radiat. Plasma Med. Sci.

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SPECT imaging of the dopamine transporter (DAT) is used for diagnosis and monitoring progression of Parkinson’s Disease (PD), and differentiation of PD from other neurological disorders. The diagnosis is based on the DAT binding in the caudate and putamen structures in the striatum. We previously proposed a relatively inexpensive method to improve the detection and quantification of these structures for dual-head SPECT by replacing one of the fan-beam collimators with a specially designed multi-pinhole (MPH) collimator. In this work, we developed a realistic model of the proposed MPH system using the GATE simulation package and verified the geometry with an analytic simulator. Point source projections from these simulations closely matched confirming the accuracy of the pinhole geometries. The reconstruction of a hot-rod phantom showed that 4.8 mm resolution is achievable. The reconstructions of the XCAT brain phantom showed clear separation of the putamen and caudate, which is expected to improve the quantification of DAT imaging and PD diagnosis. Using this GATE model, point spread functions modeling physical factors will be generated for use in reconstruction. Also, further improvements in geometry are being investigated to increase the sensitivity of this base system while maintaining a target spatial resolution of 4.5–5 mm.

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CERASPECT: a brain-dedicated SPECT system. Performance evaluation and comparison with the rotating gamma camera

Cited by 16 publications

References 10 publications

Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging

Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging

Parallel-hole collimator concept for stationary SPECT imaging

Simulations of a Multipinhole SPECT Collimator for Clinical Dopamine Transporter (DAT) Imaging

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