Ceramic TiO2-foams: characterisation of a potential scaffold

Haugen, Håvard Jostein; Will, J.; Köhler, Anne; Hopfner, Úrsula; Aigner, J.; Wintermantel, E.

doi:10.1016/s0955-2219(03)00255-3

Cited by 116 publications

(60 citation statements)

References 28 publications

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“…To our knowledge, there are only a few studies on the permeability assessment/evaluation of porous bioceramic scaffolds including both numerical modeling [147] and experimental determination of permeability constants [95,145,148,149]. In a recent study on bioactive glass-ceramic scaffolds confirming that the fabricated scaffolds had transport properties as well as pore structure close to trabecular bone.…”

Section: Bioactive Glass Based Glass-ceramic Scaffoldsmentioning

confidence: 99%

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Chatzistavrou

2011

Bioactive Glasses

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Traditionally, bioactive glasses have been used to fill and restore bone defects. More recently, this category of biomaterials has become an emerging research field for bone tissue engineering applications. Here, we review and discuss current knowledge on porous bone tissue engineering scaffolds on the basis of melt-derived bioactive silicate glass compositions and relevant composite structures. Starting with an excerpt on the history of bioactive glasses, as well as on fundamental requirements for bone tissue engineering scaffolds, a detailed overview on recent developments of bioactive glass and glass-ceramic scaffolds will be given, including a summary of common fabrication methods and a discussion on the microstructural-mechanical properties of scaffolds in relation to human bone (structure-property and structure-function relationship). In addition, ion release effects of bioactive glasses concerning osteogenic and angiogenic responses are addressed. Finally, areas of future research are highlighted in this review.

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Section: Bioactive Glass Based Glass-ceramic Scaffoldsmentioning

confidence: 99%

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Chatzistavrou

2011

Bioactive Glasses

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“…O rutilo (TiO 2 ) tem sido estudado como um material promissor de arcabouços para induzir a formação de osso na restauração de grandes defeitos ósseos [4][5][6][7]. O óxido de titânio é utilizado em implante ósseo em função da biocompatibilidade e alta confiabilidade mecânica.…”

Section: Introductionunclassified

Desenvolvimento de arcabouços de óxido de titânio e Biosilicato® para regeneração óssea

Fernandes

Morelli

2017

Cerâmica

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Resumo Arcabouços de óxido de titânio (TiO2) com Biosilicato® incorporado foram produzidos e avaliados com relação à porosidade e microestrutura. Arcabouços para regeneração óssea devem apresentar porosidade que favoreça o crescimento de tecidos ósseos através do material. O TiO2 é um material cerâmico altamente biocompatível com boas propriedades mecânicas e osseocondutoras, permitindo a migração do tecido ósseo sobre a interface do material, mas sem estimular a atividade das células osteogênicas que geram o tecido ósseo. Com o intuito de induzir a formação de tecido ósseo o Biosilicato®, um material com elevada bioatividade, foi incorporado à matriz cerâmica de TiO2. Para a obtenção dos macroporos foi utilizado o método de eliminação por queima, no qual partículas orgânicas são empregadas na matriz cerâmica como agentes formadores de poros, que possui a vantagem de adaptar as características dos poros do componente cerâmico final por meio da escolha apropriada do agente formador de poros. Neste trabalho foi feita uma mistura homogênea de TiO2 com serragem de cambará e posteriormente adicionou-se o Biosilicato®. Após a queima as amostras foram avaliadas pelo método de Arquimedes, para a determinação da porosidade aparente, e por microscopia eletrônica de varredura (MEV) para a visualização da morfologia dos grãos e distribuição e tamanho de poros. A etapa de queima garantiu a eliminação completa dos agentes formadores de poros e a completa sinterização do TiO2. O Biosilicato® facilitou a sinterização do TiO2 e a consolidação da matriz cerâmica. Foram obtidos arcabouços com porosidade aparente de 63% e poros com tamanhos maiores que 200 µm. Por meio da análise de MEV, observou-se a distribuição homogênea dos poros e suas interligações. Além disso, foi possível observar a distribuição do Biosilicato® entre as partículas de TiO2, sendo um caminho para o crescimento e regeneração do tecido ósseo.

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“…Fabrication of highly porous TiO 2 ceramic scaffolds with interconnected pore structure has been previously reported [7]− [10]. The most widely used technique for fabrication of such structures is polymer foam replica method [8]− [13]. It was invented by Schwartzwalder and Somers in 1963 [14].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Porous Titania Ceramic Scaffolds

Narkevica

Stradiņa

Yakushin

et al. 2015

SJ MSAC

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− Biocompatible ceramics have recently attracted increasing attention as porous scaffolds that stimulate and guide natural bone regeneration. Due to excellent biocompatibility of titania (titanium dioxide or TiO 2 ) porous three-dimensional (3D) TiO 2 structures have been proposed as promising scaffolding materials for inducing bone formation from the surrounding environment and for enhancement of vascularisation after implantation. In this paper, 3D porous TiO 2 ceramic scaffolds were produced via polymer foam replica method. This work deals with several important issues that are considered to be important for 3D scaffolds applied to regenerate bone tissue: pore size, porosity and mechanical strength. TiO 2 ceramic scaffolds with pore size 300 μm − 700 μm and porosity > 90 % were obtained. Scaffolds showed fully open and interconnected pore structure that remained after recoating them with low viscosity TiO 2 slurry. By optimising thermal treatment conditions grain growth and collapse of struts could be controlled in a way that resulted in higher compressive strength. Recoating greatly improved compressive strength and it reached 0.74±0.08 MPa after two coatings without causing changes in the open pore structure.

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Ceramic TiO2-foams: characterisation of a potential scaffold

Cited by 116 publications

References 28 publications

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Desenvolvimento de arcabouços de óxido de titânio e Biosilicato® para regeneração óssea

Preparation and Characterization of Porous Titania Ceramic Scaffolds

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