Ceramic Nanoparticles for Cancer Treatment

Baeza, Alejandro

doi:10.1002/9781118406748.ch14

Cited by 9 publications

(6 citation statements)

References 156 publications

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“…Applying magnetism yielded multifunctional magnetic 3D scaffolds which are responsive to an external magnetic field (EMF) to address issues like treatment of bone tumors through hyperthermiabased therapy [20,21]. Hyperthermia-based bone cancer therapy is attracting more attention because of its efficiency to eradicate bone cancerous cells locally and decreasing catastrophic side effects of the other therapies such as radiotherapy (radiation) and non-targeted (systemic) chemotherapy (high dosages of chemotherapeutic drugs) [22].…”

Section: Hyperthermia-based Therapymentioning

confidence: 99%

Multifunctional Bone Scaffolds: From Regeneration to Bone Cancer Therapy

Foroughi

Bigham

Ghomi

et al. 2020

BJSTR

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Under the umbrella of bone scaffolds, there is a category called multifunctional scaffolds capable of addressing different bone-related issues-bone cancer and regeneration, simultaneously. Up to now, some techniques are being applied in clinics to deal with bone tumors. However, filling up a critical size bone defect caused by a tumor with a biomaterial to not only regenerate the defect, but also preventing recurrence of the tumor is still challenging. The present article is a mini-review introducing multifunctional scaffolds endowed with regeneration ability and more up-to-dated bone cancer therapies-hyperthermia, photothermal, and localized drug delivery.

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Section: Hyperthermia-based Therapymentioning

confidence: 99%

Multifunctional Bone Scaffolds: From Regeneration to Bone Cancer Therapy

Foroughi

Bigham

Ghomi

et al. 2020

BJSTR

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“…The discovery of EPR effect triggered the race to design nanocarriers capable to selectively deliver chemotherapeutic agents to tumoral tissue reducing the systemic toxicity caused by these drugs in healthy tissues. Thus, a vast number of different nanoparticles composed of both organic materials as polymers [ 7 ], lipids [ 8 ], and dendrimers [ 9 ] as well as by inorganic ones such as metals [ 10 ], ceramics [ 11 ], and carbon allotropes [ 12 ], among others have been reported exhibiting excellent drug delivery capacities. The selectivity of these nanocarriers has been enhanced anchoring targeting moieties such as antibodies [ 13 ], aptamers [ 14 ], proteins [ 15 ], peptides [ 16 ], and small molecules [ 17 ] on their surface.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicines

Baeza

Vallet‐Regí

2020

Pharmaceutics

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Nanoparticles have become a powerful tool in oncology not only as carrier of the highly toxic chemotherapeutic drugs but also as imaging contrast agents that provide valuable information about the state of the disease and its progression. The enhanced permeation and retention effect for loaded nanocarriers in tumors allow substantial improvement of selectivity and safety of anticancer nanomedicines. Additionally, the possibility to design stimuli-responsive nanocarriers able to release their payload in response to specific stimuli provide an excellent control on the administered dosage. The aim of this review is not to present a comprehensive revision of the different theranostic mesoporous silica nanoparticles (MSN) which have been published in the recent years but just to describe a few selected examples to offer a panoramic view to the reader about the suitability and effectiveness of these nanocarriers in the oncology field.

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“…28 Successful nanoparticles for imaging have come from a host of materials including metals, 29–32 ceramics, 33,34 biological particles, 35–41 and self-assembled polymers. 42–45 When using polymers, most often controlled radical polymerization (CRP) methods are used to synthesize nanoparticles for biomedical applications as CRP gives rise to polymers with precisely defined molecular weights.…”

Section: Introductionmentioning

confidence: 99%

“…Nanoparticle contrast agents have improved imaging of cancers by enabling both passive and active targeting of cancerous tissue . Successful nanoparticles for imaging have come from a host of materials including metals, − ceramics, , biological particles, − and self-assembled polymers. − When using polymers, most often controlled radical polymerization (CRP) methods are used to synthesize nanoparticles for biomedical applications as CRP gives rise to polymers with precisely defined molecular weights . CRP techniques are tolerant to diverse functional groups and allow for synthetic ease in creating block copolymers .…”

Section: Introductionmentioning

confidence: 99%

Optical and Magnetic Resonance Imaging Using Fluorous Colloidal Nanoparticles

et al. 2016

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Improved imaging of cancerous tissue has the potential to aid prognosis and improve patient outcome through longitudinal imaging of treatment response and disease progression. While nuclear imaging has made headway in cancer imaging, fluorinated tracers that enable magnetic resonance imaging (19F MRI) hold promise, particularly for repeated imaging sessions because nonionizing radiation is used. Fluorine MRI detects molecular signatures by imaging a fluorinated tracer and takes advantage of the spatial and anatomical resolution afforded by MRI. This manuscript describes a fluorous polymeric nanoparticle that is capable of 19F MR imaging and fluorescent tracking for in vitro and in vivo monitoring of immune cells and cancerous tissue. The fluorous particle is derived from low-molecular-weight amphiphilic copolymers that self-assemble into micelles with a hydrodynamic diameter of 260 nm. The polymer is MR-active at concentrations as low as 2.1 mM in phantom imaging studies. The fluorinated particle demonstrated rapid uptake into immune cells for potential cell-tracking or delineation of the tumor microenvironment and showed negligible toxicity. Systemic administration indicates significant uptake into two tumor types, triple-negative breast cancer and ovarian cancer, with little accumulation in off-target tissue. These results indicate a robust platform imaging agent capable of immune cell tracking and systemic disease monitoring with exceptional uptake of the nanoparticle in multiple cancer models.

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Ceramic Nanoparticles for Cancer Treatment

Cited by 9 publications

References 156 publications

Multifunctional Bone Scaffolds: From Regeneration to Bone Cancer Therapy

Multifunctional Bone Scaffolds: From Regeneration to Bone Cancer Therapy

Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicines

Optical and Magnetic Resonance Imaging Using Fluorous Colloidal Nanoparticles

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