Multifunctional Bone Scaffolds: From Regeneration to Bone Cancer Therapy

Foroughi, Firoozeh; Bigham, Ashkan; Ghomi, Erfan Rezvani; Rafienia, Mohammad; Luo, Hongrong; Khosravi, Fatemeh; Ramakrishna, Seeram

doi:10.26717/bjstr.2020.27.004572

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…However, bone substitutes currently in clinical use still lack sufficient bioactivity to enhance bone regeneration [ 8 ]. Moreover, the lack of anti-tumor function makes such substitutes incapable of killing tumor cells which may remain after clinical surgery, and thus the chance of activation and metastasis of tumor cells rises [ [9] , [10] , [11] ]. Therefore, there is an urgent need for an artificial highly bioactive bone substitute that achieved syncretic bone regeneration and tumor therapy for bone tumor treatment [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although borosilicate shows great potential in bone repairing as highly bioactive material, the current developed borosilicate didn't take into account the needs for anti-tumor treatment, which cannot achieve osteogenesis and anti-tumor therapy simultaneously [ [9] , [10] , [11] ]. In response to this issue, researchers have synthesized mesoporous bio-ceramics that can be loaded with drugs, adopting drug-loaded bio-ceramics for anti-tumor treatment [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Osteogenic and anti-tumor Cu and Mn-doped borosilicate nanoparticles for syncretic bone repair and chemodynamic therapy in bone tumor treatment

Pang

Zhao

Chen

et al. 2022

Bioactive Materials

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Critical bone defects caused by extensive excision of malignant bone tumor and the probability of tumor recurrence due to residual tumor cells make malignant bone tumor treatment a major clinical challenge. The present therapeutic strategy concentrates on implanting bone substitutes for defect filling but suffers from failures in both enhancing bone regeneration and inhibiting the growth of tumor cells. Herein, Cu and Mn-doped borosilicate nanoparticles (BSNs) were developed for syncretic bone repairing and anti-tumor treatment, which can enhance bone regeneration through the osteogenic effects of Cu 2+ and Mn 3+ ions and meanwhile induce tumor cells apoptosis through the hydroxyl radicals produced by the Fenton-like reactions of Cu 2+ and Mn 3+ ions. In vitro study showed that both osteogenic differentiation of BMSCs and angiogenesis of endothelial cells were promoted by BSNs, and consistently the critical bone defects of rats were efficiently repaired by BSNs through in vivo evaluation. Meanwhile, BSNs could generate hydroxyl radicals through Fenton-like reactions in the simulated tumor microenvironment, promote the generation of intracellular reactive oxygen species, and eventually induce tumor cell apoptosis. Besides, subcutaneous tumors of mice were effectively inhibited by BSNs without causing toxic side effects to normal tissues and organs. Altogether, Cu and Mn-doped BSNs developed in this work performed dual functions of enhancing osteogenesis and angiogenesis for bone regeneration, and inhibiting tumor growth for chemodynamic therapy, thus holding a great potential for syncretic bone repairing and anti-tumor therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Osteogenic and anti-tumor Cu and Mn-doped borosilicate nanoparticles for syncretic bone repair and chemodynamic therapy in bone tumor treatment

Pang

Zhao

Chen

et al. 2022

Bioactive Materials

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“…MHT has already shown its therapeutic efficacy in clinical trials, mostly as a combinatorial approach with other conventional therapies such as radiotherapy or chemotherapy [10][11][12]. However, an inevitable issue associated with the use of particles in this size range (less than 20 nm) [13] is their intrinsic instability [14,15], since NP tend to aggregate over long periods of time due to their large surface area-to-volume ratio [5,15,16] and also due to the magnetic dipolar attraction between the NP [17].…”

Section: Introductionmentioning

confidence: 99%

Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency

et al. 2021

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Magnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers to protect them from oxidation and enhance their colloidal electrostatic stability while maintaining their thermal efficiency. In this work, the synthesis and characterization of magnetite nanoparticles coated with fucoidan, a biopolymer with recognized biocompatibility and antitumoral activity, is reported. The potential application of NP in MHT was evaluated through the assessment of Specific Loss Power (SLP) under an electromagnetic field amplitude of 14.7 kA m−1 and at 276 kHz. For fucoidan-coated NP, it was obtained SLP values of 100 and 156 W/g, corresponding to an Intrinsic Loss Power (ILP) of 1.7 and 2.6 nHm2kg−1, respectively. These values are, in general, higher than the ones reported in the literature for non-coated magnetite NP or coated with other polymers. Furthermore, in vitro assays showed that fucoidan and fucoidan-coated NP are biocompatible. The particle size (between ca. 6 to 12 nm), heating efficiency, and biocompatibility of fucoidan-coated magnetite NP meet the required criteria for MHT application.

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Multifunctional 3D matrixes based on flexible bioglass nanofibers for potential application in postoperative therapy of osteosarcoma

Wang,

Yuan,

Dong

et al. 2024

Regenerative Biomaterials

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Postoperative treatment of osteosarcoma is one of the major challenging clinical issues since both elimination of residual tumors and acceleration of bone regeneration should be considered. Photothermal therapy has been widely studied due to its advantages of small side-effect, low-toxicity, high local selectivity, and noninversion, and bone tissue engineering is an inevitable trend in postoperative treatment of osteosarcoma. In this study, we combined the tissue engineering and photothermal therapy together, and developed a kind of multifunctional nanofibrous 3D matrixes for postoperative treatment of osteosarcoma. The flexible bioactive glass nanofibers (BGNFs) prepared by sol-gel electrospinning and calcination acted as the basic blocks, and the genipin-crosslinked gelatin (GNP-Gel) acted as the cement to bond the BGNFs forming a stable 3D structure. The stable porous 3D scaffolds were obtained through ice crystal templating method and freeze-drying technology. The obtained GNP-Gel/BGNF 3D matrixes showed a nanofibrous structure that highly biomimetics the extracellular matrix. The excellent compression recovery performance in water of these matrixes made them suitable for minimally invasive surgery. In addition, these 3D matrixes were not only biocompatible in vitro, but also benefit for the formation of mineralized bone in vivo. Furthermore, the dark blue GNP-Gel also acted as the photothermal agent, which e endowed the GNP-Gel/BGNF 3D matrixes with efficient photothermal antitumor and photothermal antibacterial performance without addition of other toxic photothermal agents. Therefore, this study provides an ingenious avenue to prepare multifunctional nanofibrous 3D matrixes with photothermal therapy for postoperative treatment of osteosarcoma.

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Multifunctional Bone Scaffolds: From Regeneration to Bone Cancer Therapy

Cited by 4 publications

References 38 publications

Osteogenic and anti-tumor Cu and Mn-doped borosilicate nanoparticles for syncretic bone repair and chemodynamic therapy in bone tumor treatment

Osteogenic and anti-tumor Cu and Mn-doped borosilicate nanoparticles for syncretic bone repair and chemodynamic therapy in bone tumor treatment

Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency

Multifunctional 3D matrixes based on flexible bioglass nanofibers for potential application in postoperative therapy of osteosarcoma

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