Cepharanthine inhibits hepatocellular carcinoma cell growth and proliferation by regulating amino acid metabolism and suppresses tumorigenesis <i>in vivo</i>

Feng, Fan; Pan, Lianhong; Wu, Jiaqin; Li, Lanqing; Xu, Haiying; Yang, Li; Xu, Kang; Wang, Chunli

doi:10.7150/ijbs.64675

Cited by 33 publications

(33 citation statements)

References 46 publications

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“…Microbial secondary metabolites, such as alkaloids, phenols, antibiotics, and pigments, determine the specificity and function of the flora. Tumors have various in vivo metabolisms, including amino acid metabolism associated with liver cancer cells ( Feng et al, 2021 ), Glucose metabolism is associated with gastric cancer ( Fu et al, 2022 ). Lipid metabolism is related to liver cancer ( Pan et al, 2021 ) and glycolysis ( Li et al, 2022 ; Pan et al, 2022 ).…”

Section: Probiotics Assist Tumor Therapy By Modulating Metabolismmentioning

confidence: 99%

The role of the gut microbiota and probiotics associated with microbial metabolisms in cancer prevention and therapy

Wang

et al. 2022

Front. Pharmacol.

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Cancer is the second leading cause of elevated mortality worldwide. Thus, the development of drugs and treatments is needed to enhance the survival rate of the cancer-affected population. Recently, gut microbiota research in the healthy development of the human body has garnered widespread attention. Many reports indicate that changes in the gut microbiota are strongly associated with chronic inflammation-related diseases, including colitis, liver disease, and cancer within the intestine and the extraintestinal tract. Different gut bacteria are vital in the occurrence and development of tumors within the gut and extraintestinal tract. The human gut microbiome has significant implications for human physiology, including metabolism, nutrient absorption, and immune function. Moreover, diet and lifestyle habits are involved in the evolution of the human microbiome throughout the lifetime of the host and are involved in drug metabolism. Probiotics are a functional food with a protective role in cancer development in animal models. Probiotics alter the gut microbiota in the host; thus, beneficial bacterial activity is stimulated, and detrimental activity is inhibited. Clinical applications have revealed that some probiotic strains could reduce the occurrence of postoperative inflammation among cancer patients. An association network was constructed by analyzing the previous literature to explore the role of probiotics from the anti-tumor perspective. Therefore, it provides direction and insights for research on tumor treatment.

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Section: Probiotics Assist Tumor Therapy By Modulating Metabolismmentioning

confidence: 99%

The role of the gut microbiota and probiotics associated with microbial metabolisms in cancer prevention and therapy

Wang

et al. 2022

Front. Pharmacol.

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“…In addition, CEP also suppressed endogenous ANO1 currents, significantly inhibited cell proliferation and migration, and induced death in lung cancer cells [ 104 ]. In addition, CEP could be used as a candidate drug for HCC that suppresses cell migration and proliferation [ 105 ]. IR-783, a near-infrared heptamethine cyanine dye, has a potential anti-cancer role.…”

Section: Resultsmentioning

confidence: 99%

Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review

Xing

Liu

et al. 2022

World J Surg Onc

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Background Mitochondria play critical roles in cellular physiological activity as cellular organelles. Under extracellular stimulation, mitochondria undergo constant fusion and fission to meet different cellular demands. Mitochondrial dynamics, which are involved in mitochondrial fusion and fission, are regulated by specialized proteins and lipids, and their dysregulation causes human diseases, such as cancer. The advanced literature about the crucial role of mitochondrial dynamics in breast cancer is performed. Methods All related studies were systematically searched through online databases (PubMed, Web of Science, and EMBASE) using keywords (e.g., breast cancer, mitochondrial, fission, and fusion), and these studies were then screened through the preset inclusion and exclusion criteria. Results Eligible studies (n = 19) were evaluated and discussed in the systematic review. These advanced studies established the roles of mitochondrial fission and fusion of breast cancer in the metabolism, proliferation, survival, and metastasis. Importantly, the manipulating of mitochondrial dynamic is significant for the progresses of breast cancer. Conclusion Understanding the mechanisms underlying mitochondrial fission and fusion during tumorigenesis is important for improving breast cancer treatments.

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“…Moreover, perturbation of amino acid metabolism was also correlated with the progression of hepatic live diseases ( 51 ). Noticeably, cepharanthine treatment could inhibit HCC cell proliferation and migration by regulating amino acid metabolism ( 52 ). Of note, hepatic tissue in individuals stores almost 70% of retinoids ( 53 ); as reported, the inhibition of retinoids or the loss of hepatic retinoid signaling potentially leads to oxidative stress ( 54 ), which was associated with the progression of liver diseases ( 55 ).…”

Section: Discussionmentioning

confidence: 99%

Overweight/obesity-related transcriptomic signature as a correlate of clinical outcome, immune microenvironment, and treatment response in hepatocellular carcinoma

Feng

Zhang

et al. 2023

Front. Endocrinol.

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BackgroundsThe pandemic of overweight and obesity (quantified by body mass index (BMI) ≥ 25) has rapidly raised the patient number of non-alcoholic fatty hepatocellular carcinoma (HCC), and several clinical trials have shown that BMI is associated with the prognosis of HCC. However, whether overweight/obesity is an independent prognostic factor is arguable, and the role of overweight/obesity-related metabolisms in the progression of HCC is scarcely known.Materials and methodsIn the present study, clinical information, mRNA expression profile, and genomic data were downloaded from The Cancer Genome Atlas (TCGA) as a training cohort (TCGA-HCC) for the identification of overweight/obesity-related transcriptome. Machine learning and the Cox regression analysis were conducted for the construction of the overweight/obesity-associated gene (OAG) signature. The Kaplan–Meier curve, receiver operating characteristic (ROC) curve, and the Cox regression analysis were performed to assess the prognostic value of the OAG signature, which was further validated in two independent retrospective cohorts from the International Cancer Genome Consortium (ICGC) and Gene Expression Omnibus (GEO). Subsequently, functional enrichment, genomic profiling, and tumor microenvironment (TME) evaluation were utilized to characterize biological activities associated with the OAG signature. GSE109211 and GSE104580 were retrieved to evaluate the underlying response of sorafenib and transcatheter arterial chemoembolization (TACE) treatment, respectively. The Genomics of Drug Sensitivity in Cancer (GDSC) database was employed for the evaluation of chemotherapeutic response.ResultsOverweight/obesity-associated transcriptome was mainly involved in metabolic processes and noticeably and markedly correlated with prognosis and TME of HCC. Afterward, a novel established OAG signature (including 17 genes, namely, GAGE2D, PDE6A, GABRR1, DCAF8L1, DPYSL4, SLC6A3, MMP3, RIBC2, KCNH2, HTRA3, PDX1, ATHL1, PRTG, SHC4, C21orf29, SMIM32, and C1orf133) divided patients into high and low OAG score groups with distinct prognosis (median overall survival (OS): 24.87 vs. 83.51 months, p < 0.0001), and the values of area under ROC curve (AUC) in predicting 1-, 2-, 3-, and 4-year OS were 0.81, 0.80, 0.83, and 0.85, respectively. Moreover, the OAG score was independent of clinical features and also exhibited a good ability for prognosis prediction in the ICGC-LIHC-JP cohort and GSE54236 dataset. Expectedly, the OAG score was also highly correlated with metabolic processes, especially oxidative-related signaling pathways. Furthermore, abundant enrichment of chemokines, receptors, MHC molecules, and other immunomodulators as well as PD-L1/PD-1 expression among patients with high OAG scores indicated that they might have better responses to immunotherapy. However, probably exclusion of T cells from infiltrating tumors resulting in lower infiltration of effective T cells would restrict immunotherapeutic effects. In addition, the OAG score was significantly associated with the response of sorafenib and TACE treatment.ConclusionsOverall, this study comprehensively disclosed the relationship between BMI-guided transcriptome and HCC. Moreover, the OAG signature had the potential clinical applications in the future to promote clinical management and precision medicine of HCC.

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Cepharanthine inhibits hepatocellular carcinoma cell growth and proliferation by regulating amino acid metabolism and suppresses tumorigenesis in vivo

Cited by 33 publications

References 46 publications

The role of the gut microbiota and probiotics associated with microbial metabolisms in cancer prevention and therapy

The role of the gut microbiota and probiotics associated with microbial metabolisms in cancer prevention and therapy

Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review

Overweight/obesity-related transcriptomic signature as a correlate of clinical outcome, immune microenvironment, and treatment response in hepatocellular carcinoma

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