Cephalosporin-resistant Shigella flexneri over 9 years (2001-09) in India

Taneja, Neelam; Mewara, Abhishek; Kumar, Ajay; Verma, Garima; Sharma, Mukut

doi:10.1093/jac/dks061

Cited by 69 publications

(51 citation statements)

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“…The increasing levels of antimicrobial resistance of Shigella isolates have complicated the treatment of shigellosis. The antimicrobial resistance patterns of Shigella species differ according to geographic area and in the same place over time, leading to therapeutic problems (2,(18)(19)(20). Periodic regional monitoring of disease with serotype breakdown and regular periodic antibiotic-susceptibility testing patterns of isolates to guide local empirical therapy are important factors for the adequate control of shigellosis.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Shigella species and Antimicrobial Resistance Patterns of Isolated Strains from Infected Pediatrics in Tehran

Mardaneh¹,

Poor²,

Afrugh³

2013

Int J Enteric Pathog

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Background:Shigella is an infectious food-borne pathogen that can cause a severe diarrhea illness called shigellosis. The increasing levels of antimicrobial resistance of Shigella isolates have complicated the treatment of shigellosis. The antimicrobial resistance patterns of Shigella species vary according to geographic region and in the same place over time, leading to a therapeutic problem. Objectives: This study attempts to determine the prevalence of shigellosis and the antimicrobial susceptibility pattern of isolated strains. Materials and Methods:This cross-sectional study, with a 12-month duration, between August 2010 and August 2011 was carried out on 9131 infants with acute diarrheal disease. Stool samples were inoculated on selective and differential media. The Shigella isolates were identified and confirmed by biochemical laboratory tests. Subsequently, serotyping was performed with group specific antisera. Drug sensitivity test was carried out according to CLSI (2010) recommendations by using the standard disc diffusion method. Results: Shigella spp. were isolated from 90 (1%) of the 9131 stool samples collected from children with acute diarrhea. Among Shigella isolates, the most common subgroup was S. sonnei 63 (70%). Our results showed that imipenem, ciprofloxacin, ceftazidime and ceftizoxime are most effective antimicrobial agents against Shigellasp. The most frequent resistance observed, was towards co-trimoxazole (92.2%), ampicillin (65.6%) and tetracycline (65.6%) Conclusion: Since antibiotic resistant profile of Shigella varies geographically and also over time within a single country, regular, continuous surveillance is necessary. The results of accurate surveillance should be used to guide policies for antibiotic prescription.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Shigella species and Antimicrobial Resistance Patterns of Isolated Strains from Infected Pediatrics in Tehran

Mardaneh¹,

Poor²,

Afrugh³

2013

Int J Enteric Pathog

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“…bla TEM was the most common β-lactamase gene followed by bla CTX-M-1 , which was found to be the most frequent type of cephalosporinase conferring resistance to third generation cephalosporins especially to cefotaxime. 6,11,27 Among the study isolates 22% and 7% were found to carry bla TEM and bla CTX-M-1 genes respectively. Similarly Taneja et al 6 reported bla CTX-M-1 (n=10) in S. flexneri isolates, thus indicating the consistent prevalence in India.…”

Section: Discussionmentioning

confidence: 94%

“…13 Ceftriaxone resistance was also observed by a multicentre study in eight Asian countries, among Shigella isolates. 6 Generally, ampicillin resistance was encoded by OXA type β-lactamases. Overall, in the current study, 41% of the isolates harbored bla OXA genes.…”

Section: Discussionmentioning

confidence: 99%

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Molecular characterization of antimicrobial resistance in clinical Shigella isolates during 2014 and 2015: trends in South India

Anandan

Sethuvel

Gajendiren

et al. 2017

Germs

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“…11 Multidrug resistance in Shigella spp is also found at high rate. 12 Therefore, investigation of new drugs and materials to face the emerging resistance is needed.…”

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confidence: 99%

Gallic acid conjugated with gold nanoparticles: antibacterial activity and mechanism of action on foodborne pathogens

Rattanata¹,

Klaynongsruang²,

Leelayuwat

et al. 2016

IJN

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Foodborne pathogens, including Plesiomonas shigelloides and Shigella flexneri B, are the major cause of diarrheal endemics worldwide. Antibiotic drug resistance is increasing. Therefore, bioactive compounds with antibacterial activity, such as gallic acid (GA), are needed. Gold nanoparticles (AuNPs) are used as drug delivery agents. This study aimed to conjugate and characterize AuNP–GA and to evaluate the antibacterial activity. AuNP was conjugated with GA, and the core–shell structures were characterized by small-angle X-ray scattering and transmission electron microscopy. Antibacterial activity of AuNP–GA against P. shigelloides and S. flexneri B was evaluated by well diffusion method. AuNP–GA bactericidal mechanism was elucidated by Fourier transform infrared microspectroscopic analysis. The results of small-angle X-ray scattering showed that AuNP–GA conjugation was successful. Antibacterial activity of GA against both bacteria was improved by conjugation with AuNP because the minimum inhibitory concentration value of AuNP–GA was significantly decreased ( P <0.0001) compared to that of GA. Fourier transform infrared analysis revealed that AuNP–GA resulted in alterations of lipids, proteins, and nucleic acids at the bacterial cell membrane. Our findings show that AuNP–GA has potential for further application in biomedical sciences.

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Cephalosporin-resistant Shigella flexneri over 9 years (2001-09) in India

Abstract: We report a high level of cephalosporin resistance with high MICs and ESBL- and AmpC-mediated antibiotic resistance in Shigella from north India.

Cited by 69 publications

References 30 publications

Prevalence of Shigella species and Antimicrobial Resistance Patterns of Isolated Strains from Infected Pediatrics in Tehran

Prevalence of Shigella species and Antimicrobial Resistance Patterns of Isolated Strains from Infected Pediatrics in Tehran

Molecular characterization of antimicrobial resistance in clinical Shigella isolates during 2014 and 2015: trends in South India

Gallic acid conjugated with gold nanoparticles: antibacterial activity and mechanism of action on foodborne pathogens

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