Cephalometric measurements and facial deformities in subjects with  -thalassaemia major

Alhaija, Elham S. Abu; Hattab, Faiez N.; Alomari, M.

doi:10.1093/ejo/24.1.9

Cited by 72 publications

(102 citation statements)

References 14 publications

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“…In Qatar, Abu Alhaija et al [5] conducted measurements of the lateral cephalograms of 37 thalassemia patients (24 males and 13 females between 5 and 16 years of age). The thalassemia group patients were found to have a class II skeletal model, and their maxillae were found to be normal in size; meanwhile, the smaller length of the cranial base was suggested to result from the short mandible [5].…”

Section: Discussionmentioning

confidence: 99%

“…The thalassemia group patients were found to have a class II skeletal model, and their maxillae were found to be normal in size; meanwhile, the smaller length of the cranial base was suggested to result from the short mandible [5].…”

Section: Discussionmentioning

confidence: 99%

“…The craniofacial features of thalassemia major patients include larger cheekbones, a rodent or "squirrel-like" face, a depressed nasal bridge, and a protruding maxilla. The deformations of the "squirrel-like" face are attributed to multi-directional growth, covering the maxillary region in particular, and dental protrusion involving the affected teeth [4][5][6]. Features characterized by prominent frontal and parietal bones, a collapsed nasal bridge, depression of the zygomaticus, and upward-slanted eyes are defined as a slightly mongoloid facial deformity in some patients [4,6].…”

Section: Introductionmentioning

confidence: 99%

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Craniofacial Characteristics of Thalassemia Major Patients

et al. 2017

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Objective: Thalassemias major are the most common autosomal recessive disorders; they are characterized by anomalies in the synthesis of the beta chains of hemoglobin and are often associated with varying degrees of craniofacial anomalies. The purpose of this study was to evaluate the craniofacial dimensions of b-thalassemia patients and to identify differences by comparing them to those of a control group. Materials and Methods:The study comprised 43 thalassemia major patients and 26 age-and sexmatched healthy control subjects. Anthropometric measurements were performed in six different craniofacial regions (head, face, nose, mouth, eyes, and ears); a total of 23 craniofacial variables were measured.Results: Craniofacial measurements in the regions of the face, nose, lips and mouth, and ears in the thalassemia major patient group yielded statistically significant differences compared to those in the control group (p<0.05). However, no statistically significant differences were observed in the measurements of the head and eye regions. Conclusion:The study increased our understanding of the craniofacial anatomy of thalassemia major patients and enabled us to obtain quantitative results.Keywords: Thalassemia major, craniofacial measurements, Turkey ÖZ Amaç: Talasemi major; otozomal resesif kalıtım paterni gösteren, hemoglobin beta zincirinin sentezinde bozukluklar ile karakterize ve genellikle değişen derecelerde kraniyofasiyal anomalilerin eşlik ettiği bir hastalıktır. Bu çalışmanın amacı, talasemi major' hastalarının kraniofasial boyutlarını değerlendirmek ve kontrol grubuna göre farklılıkları tespit etmektir.Gereç ve Yöntem: Çalışmamız; 43 Talasemi Major'lü hasta ve aynı yaş ve cinsiyet gruplarından eşleşme ile seçilen 26 sağlıklı kontrol üzerinde yapıldı. Antropometrik ölçümler altı farklı kraniofasiyal bölgeden (baş, yüz, burun, ağız, göz ve kulak bölgeleri) alındı ve toplam 23 ölçüm yapıldı.Bulgular: Yüz, burun, ağız ve kulak bölgelerinde yapılan ölçümler açısından olgu ve kontrol grupları arasında istatistiksel olarak anlamlı farklılıklar bulundu (p<0.05). Baş ve göz bölgesi ölçümleri bakımından istatistiksel olarak anlamlı fark saptanmadı(p>0,05).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Craniofacial Characteristics of Thalassemia Major Patients

et al. 2017

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“…They result primarily from hypertrophy and expansion of the erythroid marrow due to ineffective erythropoiesis (formation of erythrocytes). Orofacial changes in TM have described in earlier reports (4)(5)(6)(7)(8). TM patients are at high risk of dental caries (9,10) periodontal diseases (8,11) and oral infection (5,12).…”

Section: Introductionmentioning

confidence: 90%

Patterns of physical growth and dental development in Jordanian children and adolescents with thalassemia major

Hattab¹

2013

J Oral Sci

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Dental development and physical growth are of particular interest in pediatric dentistry and orthodontics. This study evaluated these variables in patients with thalassemia major (TM). Physical growth was assessed in 54 patients (31 males and 23 females) aged 5.5 to 18.3 years and dental development was analyzed using panoramic radiographs from 39 of the 54 patients. The Demirjian system was used to characterize dental development of the seven left mandibular permanent teeth. Chronologic age (CA) and dental age (DA) were compared using the paired t-test, and the correlation between CA and extent of delay in dental development (DA minus CA) was assessed using Pearson's correlation coefficients. Growth retardation (< 10th percentile for height and weight) was present in 75.9% of TM patients. Height less than the third percentile was noted in 41.9% (13/31) of males and 34.8% (8/23) of females. Mean (SD) body mass index was 16.5 ± 2.2 kg/m 2 . The extent of growth retardation increased with advancing age. Patient radiographs revealed a delay in dental development in 31 of 39 (79.5%) of participants (mean delay, 1.12 years in males and 0.81 years in females; range, 0.1 to 2.7 years). The mean difference between CA and DA was 0.97 years (P < 0.001). CA was significant correlated with extent of dental developmental delay (r = 0.64, P < 0.01). The results show that, among children and adolescents with TM, the proportions of those who had short stature, were underweight, and had a low growth rate increased with age. In addition, participants had significant delays in dental development. (J Oral Sci 55, [71][72][73][74][75][76][77] 2013)

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“…The typical findings in subjects with thalessemia are a class II skeletal pattern, short cranial base length, short cranial length, short mandible, increased anterior and reduced posterior vertical dimensions and severe facial disfigurement as narrated by Alhaija et al 21 Bone age was delayed in protein energy malabsorption and males were affected more than females in accordance with studies of Tanner et al 22 and Frisancho et al 23 Malnutrition affected the maturation of the skeleton more than the teeth as confirmed by Steward et al 18 and Garn et al 19 According to a recent study conducted by Nathani et al, 24 frontal sinus can also be used as predictor for evaluation of growth patterns. In fact it has been found to be more reliable than maxillary sinus in assessment of different types of malocclusions.…”

Section: Discussionmentioning

confidence: 94%