Cephalexin Therapy for Infectious Syphilis

Duncan, W. Christopher

doi:10.1001/archderm.1974.01630070045008

Search citation statements

Order By: Relevance

Paper Sections

Select...

Commenta R Y1

Alternatives To Currently Recommended Therapy1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1988

2020

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 10 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 Our patient received only 20 g of cephalexin over a period of 10 days, which was not curative but which may have delayed the appearance of the rash. Before the diagnosis, our patient received cephalexin, which may have some activity against syphilis.…”

Section: Commenta R Ymentioning

confidence: 78%

A History Lesson

et al. 2015

View full text Add to dashboard Cite

Section: Commenta R Ymentioning

confidence: 78%

A History Lesson

et al. 2015

View full text Add to dashboard Cite

“…There are also few data regarding alternatives to the presently recommended regimens for treatment of established syphilis. Studies in the late 1960sand early 1970sevaluated the utility of cephaloridine or cephalexin for syphilis therapy [35][36][37]. Cephaloridine is no longer commercially available.…”

Section: Alternatives To Currently Recommended Therapymentioning

confidence: 99%

Treatment of Syphilis: Current Recommendations, Alternatives, and Continuing Problems

Hook

1989

Clinical Infectious Diseases

View full text Add to dashboard Cite

Benzathine penicillin continues to be the cornerstone of recommended therapy for syphilis. Recent increases in the syphilis rates in the United States and concerns about the adequacy of currently recommended therapy for syphilis in patients with concomitant human immunodeficiency virus infection have stimulated reappraisal of alternatives to currently recommended therapy. Desirable features of antimicrobial agents for syphilotherapy include long serum half-life, good penetration into the central nervous system, and ease of administration. Benzathine penicillin provides prolonged treponemicidal levels of penicillin G in serum but does not reliably produce adequate levels of penicillin in the central nervous system. Tetracycline requires multiple daily dosing, has relatively frequent adverse effects, and has unproven efficacy for central nervous system involvement. Erythromycin, which may be less active than tetracycline for syphilis therapy, has similar shortcomings. Recent evaluations of ceftriaxone for early syphilis therapy are promising; however, the optimal dose and duration of therapy are unknown. No currently recommended therapy for syphilis is clearly optimal for reliable, cost-effective therapy. Careful reappraisal of currently available syphilotherapy and alternatives is needed.

show abstract

Neurosyphilis Presenting as Mania and Psychosis After Incidental Treatment With Cephalexin: A Case Report and Literature Review of Jarisch-Herxheimer Reactions

Spelber

Lahijani

2020

Psychosomatics

View full text Add to dashboard Cite

Cephalexin Therapy for Infectious Syphilis

Cited by 10 publications

References 12 publications

A History Lesson

A History Lesson

Treatment of Syphilis: Current Recommendations, Alternatives, and Continuing Problems

Neurosyphilis Presenting as Mania and Psychosis After Incidental Treatment With Cephalexin: A Case Report and Literature Review of Jarisch-Herxheimer Reactions

Contact Info

Product

Resources

About