“…Previous reports neither solve the biologic implications of the phenomemon, as PCD has been described in patients with Robert's syndrome (German 1979, Tomkins et al 1979, Petrineli et al 1984, patients with Alzheimer disease (Moorhead and Heyman 1983) in chronic myeloid leukemia (Vig 1984), in cells of patients with leukemia treated with ara-C (Sandberg 1980), patients with acute non lymphocytic leukemia (Siraishi et al 1982), in megaloblastic anemia (Bamezai et al 1986), in Burkitt's lymphoma and nasopharyngeal carcinoma cell lines (Zhang 1986), in case of bladder carcinoma (Berrozpe et al 1990), and it has been relationated with aneuploidies (Fitzgerald et al 1986). However, PCD has also been described in healthy individuals (Rudd et al 1983, Gabarron et al 1986, Madan et al 1987, Fuster et al 1992).…”