Premature Centromere Division: A cytogenetic study.

Arrieta, M. I.; Martínez, Belén Puebla; Nuñez, M.; Gil‐Solla, Alberto; Echarri, Asier; Lobato, Mark N.; Criado, Begoña; Lostao, C. M.

doi:10.1508/cytologia.60.159

Cited by 1 publication

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“…The phenomena of PCD and C-anaphase have long been considered effects of cell culture. It was later demonstrated that the levels of PCD and C-anaphase are much higher in leukemia and other pathologies in comparison with healthy individuals [3,4,5,6,7]. Various researchers have suggested that the phenomenon of PCD is associated with the emergence of aneuploid cell clones [8,9,10,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Premature Centromere Division (PCD) as a Cause of Genome Instability in Children with Acute Lymphoblastic Leukemia

Sirenko

2024

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Premature centromere division (PCD) and C-anaphase are well known phenomena in leukemias. However, their biological significance is not well understood. We describe the relationship of levels of PCD and C-anaphase with leukemic phase, blasts, aneuploidy and polyploidy in children with acute lymphoblastic leukemia (ALL). Methods Cytogenetic preparations of bone marrow (BM) and peripheral blood (PB) cells from 57 children with ALL and 15 healthy children were evaluated. For children with ALL, cells were examined prior to treatment in the acute phase and during remission. PCD and C-anaphase designations were assigned to chromosomal preparations and analyzed. Results The PCD and C-anaphase levels in BM and PB cells were significantly higher in the acute phase of ALL and decreased, approaching normal during remission. Strong correlations were found between PCD levels in PB (r = 0.890) and BM (r = 0.896) cells compared with blast levels in PB cells. Strong correlations were observed between PB levels of aneuploid (r = 0.832) and polyploid (r = 0.955) cells compared with PCD levels in PB cells. The C-anaphase levels in PB (r = 0.139) and BM (r = 0.171) compared with blasts in PB did not demonstrate a positive correlation. Conclusions Our data demonstrates that PCD is a cause of genome instability associated with ALL and that the phenomenon of PCD and C-anaphase provide additional criteria for diagnosis of ALL and its remission.

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Section: Introductionmentioning

confidence: 99%

“…In PCD, separation of centromeres is observed at the metaphase stage of some chromosomes, while centromeres of other chromosomes remain connected [3,13]. In C-anaphase, all centromeres are separated at the metaphase stage [14,15,16].…”

Section: Introductionmentioning

confidence: 99%

Premature Centromere Division (PCD) as a Cause of Genome Instability in Children with Acute Lymphoblastic Leukemia

Sirenko

2024

Preprint

View full text Add to dashboard Cite

show abstract

Premature Centromere Division: A cytogenetic study.

Cited by 1 publication

References 26 publications

Premature Centromere Division (PCD) as a Cause of Genome Instability in Children with Acute Lymphoblastic Leukemia

Premature Centromere Division (PCD) as a Cause of Genome Instability in Children with Acute Lymphoblastic Leukemia

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