Centrifugal spinning of polyvinyl alcohol/sodium alginate-di -aldehyde-gelatin based antibacterial nanofibers intended for skin tissue engineering

Akhtar, Memoona; Ahmed, Sheraz; Hussain, Rabia; Wadood, Abdul; Roy, Ipsita; Rehman, Muhammad Atiq Ur; Boccaccını, Aldo R.

doi:10.1016/j.matlet.2022.132530

Cited by 12 publications

(15 citation statements)

References 11 publications

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“…The inhibitory effect of each sample was measured by determining the diameter of the zone of inhibition, which indicates the area where bacterial growth is prevented. The diameter of the antimicrobial "halo" was calculated as follows [40]: 4), where C is the bridging of the zone of inhibition (cm), D is the susceptible zone (cm), and d is the diameter of the sample disk (cm).…”

Section: F Antibacterial Assaymentioning

confidence: 99%

Characterizations of Centrifugal Electrospun Polyvinyl Alcohol/Sodium Alginate/Tamanu Oil/Silver Nanoparticles Wound Dressing

Tran,

Luong,

Lin

2024

IEEE Trans.on Nanobioscience

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Known for its water solubility, flexibility, strong adhesion, and eco-friendly nature, polyvinyl alcohol (PVA) is widely used in various industries. In the medical field, it is used for applications such as creating bandages and orthopaedic devices. Incorporating sodium alginate (SA) into PVA membranes enhances their structural integrity, breathability, and permeability, thereby minimising the risk of cellular damage in the wound zone. Moreover, the addition of tamanu oil (Calophyllum inophyllum L.) and silver nanoparticles, both of which are known for their antibacterial properties and benefits in traditional wound healing, further enhances the membranes' woundhealing effectiveness. Following production, the membranes undergo a series of tests designed to evaluate their physical properties as well as their antioxidant and antibacterial capabilities. Subsequently, in vitro testing is conducted using human skin cells; experiments on Wistar rats are then performed. Numerous experiments have consistently demonstrated that the performance of polyvinyl alcohol/sodium alginate/tamanu oil (PVA/SA/Oil) membrane is superior to that of polyvinyl alcohol/sodium alginate/tamanu oil/silver nanoparticles (PVA/SA/Oil/Ag NP) membrane. Specifically, the polyvinyl alcohol/sodium alginate (PVA/SA) combination exhibits an impressive woundhealing rate of 98.82% after 15 days, with cells maintaining a high viability of 92% in a nourishing environment. Moreover, these membranes exhibit exceptional resistance to the oxidation of free radicals, surpassing the 70% threshold, and they possess antibacterial activity against Staphylococcus aureus subsp. aureus in vitro. Based on the obtained results, the nanofiber membranes composed of polyvinyl alcohol/ alginate/ tamanu oil, with or without silver nanoparticles, have shown potential as wound dressings in the wound care discipline.Index Terms -centrifugal electrospun nanofiber, polyvinyl alcohol/sodium alginate/tamanu oil, silver nanoparticles (Ag NP), wound healing.

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Section: F Antibacterial Assaymentioning

confidence: 99%

Characterizations of Centrifugal Electrospun Polyvinyl Alcohol/Sodium Alginate/Tamanu Oil/Silver Nanoparticles Wound Dressing

Tran,

Luong,

Lin

2024

IEEE Trans.on Nanobioscience

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“…It can also be used in skin regeneration and skin tissue engineering applications. For this purpose, poly(vinyl alcohol) (PVA)/sodium alginate dialdehyde (ADA)/gelatin(GEL) fibers were produced by centrifugal spinning (Akhtar et al, 2022). Additionally, Cu-Ag doped mesoporous bioactive glass nanoparticles (Cu-Ag MBGNs) were loaded to achieve antibacterial properties on the fibers.…”

Section: Wound Dressingsmentioning

confidence: 99%

Recent developments in the use of centrifugal spinning and pressurized gyration for biomedical applications

Ahmed

Gultekinoglu

Edirisinghe

2023

WIREs Nanomed Nanobiotechnol

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Centrifugal spinning is a technology used to generate small diameter fibers and has been extensively studied for its vast applications in biomedical engineering. Centrifugal spinning is known for its rapid production rate and has inspired the creation of other technologies which leverage the high‐speed rotation, namely Pressurized Gyration. Pressurized gyration incorporates a unique applied gas pressure which serves to provide additional control over the fiber production process. The resulting fibers are uniquely suitable for a range of healthcare‐related applications that are thoroughly discussed in this work, which involve scaffolds for tissue engineering, solid dispersions for drug delivery, antimicrobial meshes for filtration and bandage‐like fibrous coverings for wound healing. In this review, the notable recent developments in centrifugal spinning and pressurized gyration are presented and how these technologies are being used to further the range of uses of biomaterials engineering, for example the development of core‐sheath fabrication techniques for multi‐layered fibers and the combination with electrospinning to produce advanced fiber mats. The enormous potential of these technologies and their future advancements highlights how important they are in the biomedical discipline.This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology‐Inspired Nanomaterials > Lipid‐Based Structures

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“…Introducing magnetic materials [33], hydrogels [34], nanoparticles [19,35,36], biomolecules [37], etc., may provide extended properties to establish cell frameworks for tissue regeneration. The centrifugal spinning process may be modified to produce antimicrobial fibers for wound dressings and other tissue-repair therapies [13,[38][39][40]. Due to the presence of large pore structures in the fibers compared to the fibers made from other systems, it is possible to mimic the microenvironment necessary to mimic the extracellular matrix (ECM) [41].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Centrifugal Spinning and Their Applications in Tissue Engineering

et al. 2023

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Over the last decade, researchers have investigated the potential of nano and microfiber scaffolds to promote wound healing, tissue regeneration, and skin protection. The centrifugal spinning technique is favored over others due to its relatively straightforward mechanism for producing large quantities of fiber. Many polymeric materials have yet to be investigated in search of those with multifunctional properties that would make them attractive in tissue applications. This literature presents the fundamental process of fiber generation, and the effects of fabrication parameters (machine, solution) on the morphologies such as fiber diameter, distribution, alignment, porous features, and mechanical properties. Additionally, a brief discussion is presented on the underlying physics of beaded morphology and continuous fiber formation. Consequently, the study provides an overview of the current advancements in centrifugally spun polymeric fiber-based materials and their morphological features, performance, and characteristics for tissue engineering applications.

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Centrifugal spinning of polyvinyl alcohol/sodium alginate-di -aldehyde-gelatin based antibacterial nanofibers intended for skin tissue engineering

Cited by 12 publications

References 11 publications

Characterizations of Centrifugal Electrospun Polyvinyl Alcohol/Sodium Alginate/Tamanu Oil/Silver Nanoparticles Wound Dressing

Characterizations of Centrifugal Electrospun Polyvinyl Alcohol/Sodium Alginate/Tamanu Oil/Silver Nanoparticles Wound Dressing

Recent developments in the use of centrifugal spinning and pressurized gyration for biomedical applications

Recent Advances in Centrifugal Spinning and Their Applications in Tissue Engineering

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