Centrifugal microfluidic platform for radiochemistry: Potentialities for the chemical analysis of nuclear spent fuels

Bruchet, Anthony; Taniga, Vélan; Descroix, Stéphanie; Malaquin, Laurent; Goutelard, F.; Mariet, Clarisse

doi:10.1016/j.talanta.2013.06.064

Cited by 23 publications

(22 citation statements)

References 33 publications

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“…Since COC is a widely used thermoplastic material in microfluidics due to its remarkable properties, such as compatibility with biological applications, 24,25 chemical resistance 26,27 and high transparency, 28 we selected it for forthcoming evaluations.…”

Section: Resultsmentioning

confidence: 99%

A simple and low-cost chip bonding solution for high pressure, high temperature and biological applications

et al. 2017

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Section: Resultsmentioning

confidence: 99%

A simple and low-cost chip bonding solution for high pressure, high temperature and biological applications

et al. 2017

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“…The Cyclic olefin copolymer (COC, Topas ® 8007, Topas Advanced Polymers, Extrusion Lab, Frankfurt, Germany) microfluidic devices were fabricated by hot embossing and sealed using a solvent assisted bonding method, as described earlier [35,36]. Channel walls were treated with Pluronic F127 (1 wt% in water, Sigma Aldrich, St. Louis, MO, USA) to prevent nonspecific adsorption of particles or DNA molecules [35].…”

Section: Microfluidic Device Fabrication and Experimental Setupmentioning

confidence: 99%

Microfluidic extraction and digital quantification of circulating cell-free DNA from serum

Perez‐Toralla

Pereiro

Garrigou

et al. 2019

Sensors and Actuators B: Chemical

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Miniaturized devices for the extraction of DNA have been used for assessing genetic material in biological, forensic and environmental samples. However, the ability to isolate trace amounts of highly fragmented DNA from biological fluids remains a challenge. The current work reports a microfluidic approach that combines on line a dynamic magnetic extraction procedure with droplet-based digital PCR (ddPCR). This strategy maximizes the surface area for DNA binding within the chip, in order to capture short DNA fragments, with the possibility of recovering the purified samples into picoliter volumes for high sensitivity mutation detection. The application of this technology to capture circulating cell-free DNA (ccfDNA) from serum samples of cancer patients is demonstrated herein, with efficiencies comparable to standard column-based DNA extraction methods. This technology uses lesser amounts of required material and reagents, and has a higher potential for automation and multiplex DNA analysis. Furthermore, this approach can also be extended for the detection of other circulating biomarkers, such as nucleic acid sequences with aberrant methylation patterns or miRNA.

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“…With the advent of low-flow nebulization and loop injection techniques for plasma spectroscopy, it is now possible to perform comprehensive, high-sensitivity actinide impurity assay by ICP-OES using just 1 mL of column effluent [8]. Although microfluidic technology for actinide separation is still in its infancy [9][10][11][12], integrated microfluidic devices customized with solid-phase resins hold significant potential as lab-on-a-chip platforms for matrix removal in trace element assay and for related analyses of actinides. An effective microfluidic separation device would support a 10-to 100-fold reduction in sample size, with commensurate operational benefits to worker safety and waste minimization.…”

Section: Introductionmentioning

confidence: 99%

Solid-phase extraction microfluidic devices for matrix removal in trace element assay of actinide materials

Gao

Manard

Castro

et al. 2017

Talanta

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Advances in sample nebulization and injection technology have significantly reduced the volume of solution required for trace impurity analysis in plutonium and uranium materials. Correspondingly, we have designed and tested a novel chip-based microfluidic platform, containing a 100-µL or 20-µL solid-phase microextraction column, packed by centrifugation, which supports nuclear material mass and solution volume reductions of 90% or more compared to standard methods. Quantitative recovery of 28 trace elements in uranium was demonstrated using a UTEVA chromatographic resin column, and trace element recovery from thorium (a surrogate for plutonium) was similarly demonstrated using anion exchange resin AG MP-1. Of nine materials tested, compatibility of polyvinyl chloride (PVC), polypropylene (PP), and polytetrafluoroethylene (PTFE) chips with the strong nitric acid media was highest. The microcolumns can be incorporated into a variety of devices and systems, and can be loaded with other solid-phase resins for trace element assay in high-purity metals.

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Centrifugal microfluidic platform for radiochemistry: Potentialities for the chemical analysis of nuclear spent fuels

Cited by 23 publications

References 33 publications

A simple and low-cost chip bonding solution for high pressure, high temperature and biological applications

A simple and low-cost chip bonding solution for high pressure, high temperature and biological applications

Microfluidic extraction and digital quantification of circulating cell-free DNA from serum

Solid-phase extraction microfluidic devices for matrix removal in trace element assay of actinide materials

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