Centrifugal and centripetal mechanisms involved in the ‘gating’ of cortical SEPs during movement

Jones, Stephen J.; Halonen, J.-P.; Shawkat, Fatima

doi:10.1016/0168-5597(89)90049-x

Cited by 167 publications

(53 citation statements)

References 18 publications

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“…As in previous studies of either afferent or efferent gating (Abbruzzese et al 1980(Abbruzzese et al , 1981Burke et al 1982;Cohen and Starr 1987;Hsieh et al 1995;Insola et al 2004;Jones et al 1989;Klostermann et al 2002a;Tapia et al 1987), there were no changes in the latencies of any subcortical or cortical responses, nor in the amplitude of the braquial plexus response (N9), indicating that the gating effect is mediated only by central structures. In particular, an interaction between lemniscal and spinocerebellar inputs has been suggested to occur at a thalamic level Okajima et al 1991).…”

Section: Interactions Between Muscle and Cutaneous Afferent Volleyssupporting

confidence: 50%

Subcortical Interactions Between Somatosensory Stimuli of Different Modalities and Their Temporal Profile

Costa¹,

Valls‐Solé²,

Valldeoriola³

et al. 2008

Journal of Neurophysiology

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Costa J, Valls-Solé J, Valldeoriola F, Rumià J. Subcortical interactions between somatosensory stimuli of different modalities and their temporal profile. J Neurophysiol 100: 1610 -1621, 2008. First published July 2, 2008 doi:10.1152/jn.90412.2008. Interactions between inputs of different sensory modality occur along the sensory pathway, including the thalamus. However, the temporal profile of such interaction has not been fully studied. In eight patients who had been implanted an intrathalamic electrode for deep brain stimulation as symptomatic treatment of tremor, we investigated the interactions between mechanical taps and electrical nerve stimuli. Somatosensory evoked potentials (SEPs) were recorded from Erb's point, cervical spinal cord, nucleus ventrointermedialis of the thalamus, and parietal cortex. A handheld electronic reflex hammer was used to deliver a mechanical tap to the skin overlying the first dorsal interosseous muscle and to trigger an ipsilateral digital median nerve electrical stimulus time-locked to the mechanical tap with a variable delay of 0 to 50 ms. There were significant time-dependent interactions between the two sensory volleys at the subcortical level. Thalamic SEPs were decreased in amplitude at interstimulus intervals (ISIs) from 10 to 40 ms with maximum effect at 20 ms (Ϫ42.8 Ϯ 10.5%; P Ͻ 0.001). A similar decrease was also seen in the number and frequency of the high-frequency components of thalamic SEPs (Ϫ25 Ϯ 4%). A smaller reduction (Ϫ18.1 Ϯ 5.8%; P Ͻ 0.001) was present in upper cervical response at ISI ϭ 20 ms. There were no changes in peripheral responses. Cortical SEPs were almost completely absent in some subjects at ISIs from 20 to 50 ms. There were no changes in SEP latencies. Our results indicate that significant time-dependent interactions between sensory volleys occur at the subcortical level. These observations provide further insight into the physiological mechanisms underlying afferent gating between sensory volleys of different modality.

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Section: Interactions Between Muscle and Cutaneous Afferent Volleyssupporting

confidence: 50%

Subcortical Interactions Between Somatosensory Stimuli of Different Modalities and Their Temporal Profile

Costa¹,

Valls‐Solé²,

Valldeoriola³

et al. 2008

Journal of Neurophysiology

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“…While phase resetting to the onset of an external stimulus may reflect sensation (23), early components of the averaged ERP are traditionally used to assess "gating" of sensation preceding and during motor movements (24)(25)(26)(27)(28)(29)(30)(31). For example, Rosini et al noted that early (<50ms) somatosensory ERPs to median nerve shocks are reduced contra-laterally, but not ipsi-laterally, during motor movement conditions compared to conditions with no-motor movement, suggesting that the gating of sensation is specific to the contra-lateral hemisphere.…”

Section: Introductionmentioning

confidence: 99%

Out-of-Synch and Out-of-Sorts: Dysfunction of Motor-Sensory Communication in Schizophrenia

Ford

Roach

Faustman

et al. 2008

Biological Psychiatry

125

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Background-Phase synchronization of neural activity preceding a motor act may reflect an "efference copy" of the motor plan and its expected sensory consequences ("corollary discharge"), which is sent to sensory cortex to herald the arrival of self-generated sensations and dampen the resulting sensory experience. We performed time-frequency decomposition of response-locked EEG to examine phase synchronization of oscillations across trials (phase-locking factor, PLF) to selfpaced button-presses. If pre-press PLF reflects the activity in motor cortex, it should be contralateralized. If it reflects the action of the efference copy, it should be related to subsequent sensory suppression. If efference copy/corollary discharge mechanisms are abnormal in schizophrenia, it should be reduced in patients with schizophrenia.

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“…Whereas attenuation of SEPs during movement may arise at peripheral as well as central levels ("centripetal gating"; Jones et al, 1989), pre-movement SEP suppression occurs prior to movement and the arrival of peripheral feedback, thus suggesting a central "centrifugal" mechanism (Cohen and Starr, 1987, Shimazu et al, 1999, Wasaka et al, 2003. Voss et al (2006) used transcranial magnetic stimulation to investigate the characteristics of the efferent motor signal causing sensory attenuation.…”

Section: Discussionmentioning

confidence: 99%

“…Since ssVEPs are elicited by sustained trains of repetitive stimuli, they provide a continuous measure of the modulation of sensory function by attentional processes (Müller et al, 1998). In the domain of sensorimotor function, amplitude modulations of somatosensory-evoked potentials (SEPs) have been used to probe the state of the sensorimotor system during the preparation and execution of movement (Böcker et al, 1993;Cheron and Borenstein, 1987;Cohen and Starr, 1987;Jones et al, 1989;Shimazu et al, 1999). Here, the use of a continuous measure, rather than intermittent probes by means of transient evoked responses, would potentially have a similar advantage as the use of ssVEPs in visual selective attention research.…”

Section: Introductionmentioning

confidence: 99%

Movement-related changes in cortical excitability: A steady-state SEP approach

2008

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Centrifugal and centripetal mechanisms involved in the ‘gating’ of cortical SEPs during movement

Cited by 167 publications

References 18 publications

Subcortical Interactions Between Somatosensory Stimuli of Different Modalities and Their Temporal Profile

Subcortical Interactions Between Somatosensory Stimuli of Different Modalities and Their Temporal Profile

Out-of-Synch and Out-of-Sorts: Dysfunction of Motor-Sensory Communication in Schizophrenia

Movement-related changes in cortical excitability: A steady-state SEP approach

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