Central Thickness in Corneal Disorders

Ehlers, Niels; Bramsen, Thorkild

doi:10.1111/j.1755-3768.1978.tb05694.x

Cited by 26 publications

(7 citation statements)

References 6 publications

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“…MCD is often associated with reduced central corneal thickness. 15 - 17 In accordance with the literature, we found that corneal thickness at the apex and at the thinnest location is thinner in MCD group than in other groups. Corneal thickness data guides clinician during the treatment planning: PTK, lamellar or penetrating keratoplasty.…”

Section: Discussionsupporting

confidence: 91%

Corneal Topography Analysis of Stromal Corneal Dystrophies

et al. 2014

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Objective:The aim was to compare the corneal topography and tomography parameters of macular corneal dystrophy (MCD), granular corneal dystrophy (GCD) and lattice corneal dystrophy (LCD) patients obtained by Scheimpflug imaging system.Methods:The charts, photographs and topography images of patients were reviewed retrospectively. This study included 73 eyes of 73 patients (28 MCD, 20 GCG and 25 LCD patients). Topography images were obtained by Pentacam (Oculus Optikgerate, Wetzlar, Germany). The densitometry readings at the corneal apex were used for the statistics.Results:The female to male ratio was 13/15 in MCD group, 12/8 in GCD group and 13/12 in LCD group. The mean age median age was 32, 45 and 53 years in MCD, GCD and LCD groups respectively. The groups were similar regarding the gender (p=0.861). The MCD group was significantly younger than the other two groups (p<0.001). The median (minmum-maximum) corneal densities were 100 (100-100), 68 (17-100) and 97 (34-100) Pentacam densitometry units in MCD, GCD and LCD groups respectively. The corneal density at the corneal apex was significantly higher in MCD group than in the other groups (p<0.001). The GCD and LCD groups were statistically similar in terms of density of the corneal apex (p=0.079). In MCD group, corneal thickness at the apex and at the thinnest location was significantly thinner, than in the other groups (p=.002 for thickness at apex between MCD and LCD, and p<.001 for all the remaining comparisons). In MCD group corneal volume was significantly smaller than in the other groups (p<.001 for all comparisons).Conclusion:Densitometry on Scheimpflug imaging system gives information on the density of corneal opacities.

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Section: Discussionsupporting

confidence: 91%

Corneal Topography Analysis of Stromal Corneal Dystrophies

et al. 2014

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“…The central cornea thickness of healthy young men measured by Ehlers & Bramsen (mean 0.5097 mm) by the same modification of the Haag-Streit pachymeter as used in this study was very much like the central cornea thickness measured in our control group (Ehlers & Bramsen 1978).…”

Section: Discussionsupporting

confidence: 68%

Increased Central Cornea Thickness in Systemic Sclerosis

Serup¹,

Serup

Hagdrup

1984

Acta Ophthalmologica

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Central cornea thickness (CCT) was measured in 32 patients with systemic sclerosis by the Haag-Streit pachymeter with improved centrality. Results were compared with measurements in 29 healthy adults matched with respect to sex and age. CCT was increased (P less than 0.001) in patients with systemic sclerosis (mean 0.56 mm, average SD right and left side 0.0297 mm) as compared to the controls (mean 0.51 mm, SD 0.0109 mm). CCT of right and left eye was increased in 69% and 72% of patients with systemic sclerosis as compared to controls (mean 0.51 mm +/- 2 SD). CCT increased during the first 8 years of the disease (correlation coefficient 0.593) reaching a plateau after 8 years (correlation coefficient 0.005). CCT did not increase during medical treatment with collagen inhibitors. Measurement of CCT may be useful as a supplement to other quantitative methods for diagnosis and control of systemic sclerosis.

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“…However, if statistically significant CCT values are taken from a different set of research the computed required sensitivity for these pathologies are: Keratoconus 4% [45], Fuchs dystrophy 1.0% [46], and refractive surgery 8.5% [47]. Further, CCT measurements of in vivo healthy cornea suggest that average CTWC increases of <5% result in slight to no effect on the refractive, transparency, and mechanical functions of the cornea and diurnal percent increase in CTWC can occur during sleep [48]. The stark disagreement and inconsistency between published CCT values and estimated CTWC demonstrate the poor understanding between the coupling of thickness and CTWC and indicate that CTWC measurement is both a clinical and a basic research problem.…”

Section: Corneal Tissue Water Contentmentioning

confidence: 99%

THz and mm-Wave Sensing of Corneal Tissue Water Content: Electromagnetic Modeling and Analysis

Taylor

Garritano

Sung

et al. 2015

IEEE Trans. THz Sci. Technol.

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Terahertz (THz) spectral properties of human cornea are explored as a function of central corneal thickness (CCT) and corneal water content, and the clinical utility of THz-based corneal water content sensing is discussed. Three candidate corneal tissue water content (CTWC) perturbations, based on corneal physiology, are investigated that affect the axial water distribution and total thickness. The THz frequency reflectivity properties of the three CTWC perturbations were simulated and explored with varying system center frequency and bandwidths (Q-factors). The modeling showed that at effective optical path lengths on the order of a wavelength the cornea presents a lossy etalon bordered by air at the anterior and the aqueous humor at the posterior. The simulated standing wave peak-to-valley ratio is pronounced at lower frequencies and its effect on acquired data can be modulated by adjusting the bandwidth of the sensing system. These observations are supported with experimental spectroscopic data. The results suggest that a priori knowledge of corneal thickness can be utilized for accurate assessments of corneal tissue water content. The physiologic variation of corneal thickness with respect to the wavelengths spanned by the THz band is extremely limited compared to all other structures in the body making CTWC sensing unique amongst all proposed applications of THz medical imaging.

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Central Thickness in Corneal Disorders

Cited by 26 publications

References 6 publications

Corneal Topography Analysis of Stromal Corneal Dystrophies

Corneal Topography Analysis of Stromal Corneal Dystrophies

Increased Central Cornea Thickness in Systemic Sclerosis

THz and mm-Wave Sensing of Corneal Tissue Water Content: Electromagnetic Modeling and Analysis

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