Central serous chorioretinopathy associated with testosterone therapy

Ahad, Muhammad A.; Chua, C N; Evans, Non

doi:10.1038/sj.eye.6701905

Cited by 33 publications

(25 citation statements)

References 9 publications

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“…The patient developed CSCR 1 month after increased dosing of testosterone. 22 A second case was reported of a 45-year-old woman treated with oral testosterone therapy for general fatigue. She developed CSCR 5 weeks after initiation of therapy.…”

Section: Discussionmentioning

confidence: 97%

Central Serous Chorioretinopathy in Patients Receiving Exogenous Testosterone Therapy

Nudleman

Witmer

Kiss

et al. 2014

Retina

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Section: Discussionmentioning

confidence: 97%

Central Serous Chorioretinopathy in Patients Receiving Exogenous Testosterone Therapy

Nudleman

Witmer

Kiss

et al. 2014

Retina

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“…On the contrary, number of case reports of CSCR after systemic testosterone therapy shows indirect evidence of the role of testosterone in CSCR. [14,15] Indirectly these case reports are emphasizing on the association between testosterone and CSCR. Except these case reports there is no conclusive study that clearly shows role of testosterone in CSCR.…”

Section: Discussionmentioning

confidence: 99%

“…Some previous studies have tried to constitute a link between testosterone and CSCR, but with only ambiguous results. [9,[14][15][16][17] The incidence of CSCR decreases as the age advances which correlates with the gradual decline in the total plasma testosterone levels with advancing age in older men, [18] which further strengthens the possibility of testosterone's involvement in the development of the disease.…”

Section: Introductionmentioning

confidence: 96%

Endogenous Cortisol and Testosterone Level in Central Serous Chorioretinopathy: A Case Control Study

Sachdeva¹

2017

WJPR

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Central serous chorioretinopathy (CSCR) is characterized by anexudative neurosensory layer detachment of retina. Male gender, type-A personality, emotional stress, pregnancy, infections, hormonal regulatory factors and several immunological reactions have all been implicated in causing CSCR. Although several hypotheses have tried to establish a link between endocrinal abnormalities and CSCR, still none is able to explain the true etiopathogenesis of CSCR. This study was designed to estimate serum cortisol and testosterone levels in patients of CSCR and study their potential role in etiopathogenesis of the disease. In this study, 25 patients of CSCR satisfying the inclusion and exclusion criteria were enrolled as cases and 25 age and sex matched patients with an acute unilateral rhegmatogenous retinal detachment (RD) were enrolled as controls. Levels of serum cortisol and testosterone were estimated in both groups. Serum cortisol measurement was done twice, due to diurnal variation in its levels. Data analysis was done by Pearson's correlation analysis and independent student t-test. The 8:00 AM mean serum cortisol value in the cases (20.21 ± 4.86 μg/dl) was significantly (p = 0.046) higher than controls (17.74 ± 3.53 μg/dl). Although the 11:00 PM mean serum cortisol value of cases (8.13 ± 3.52 μg/dl)

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“…Central Serous Retinopathy is associated with elevated serum cortisol levels, endogenous hypercortisolism, use of costicosteroids in various forms and high testosterone levels, specially related to corticosteroid or testosterone therapy [1,3,4,7]. Our patient was not under any corticosteroid nor testosterone therapy and in biochemical examination, the hormones serum level (FSH, LH, PRL, PRG, E2, Testosterone, DHEA-S, β-hcg) was normal, apart from cortisol which was a little bit elevated (21.1 μg/dl, normal ranges: 6.2 -19.4 μg/ dl).…”

Section: Case Reportmentioning

confidence: 99%

Central Serous Chorioretinopathy With Multiple Leakage Points in a Young Female Patient Without Detected Risk Factors

Chatziralli¹

2012

J Med Cases

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Central Serous Chorioretinopathy (CSR) is characterized by the accumulation of subretinal fluid at the posterior pole of the fundus, causing serous detachment of the neurosensory retina and/or retinal pigment epithelium. CSR typically affects young and middle-aged men between 20 and 40 years old with type-A personality and is associated with emotional stress. A 21-year-old non-pregnant female presented with a 2-day history of acute, sudden, painless loss of vision and metamorphopsia at the right eye. She complainted also for a central scotoma. On examination of the right eye, the best-corrected visual acuity (BCVA) was 3/10. Dilated fundus examination revealed a neurosensory serous detachment and the diagnosis of CSR was confirmed by fluorescein angiography and optical coherence tomography (OCT). Interestingly, the fluorescein angiography revealed multiple leakage points of the dye related to retinal pigmented epithelium defects, while OCT demonstrated a significantly increased retinal thickness. The most astonishing feature of this case report is that it concerns a female patient with acute CSR without any detected risk factors that was characterized by significantly high retinal thickness in OCT in parallel with multiple leakages in fluorescein angiography. As a result, CSR should be taken into account in the differential diagnosis of sudden, painless loss of vision, although the patient may be female without risk factors.

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Central serous chorioretinopathy associated with testosterone therapy

Abstract: due to Rothia dentocariosa in a patient receiving continuous ambulatory peritoneal dialysis.

Cited by 33 publications

References 9 publications

Central Serous Chorioretinopathy in Patients Receiving Exogenous Testosterone Therapy

Central Serous Chorioretinopathy in Patients Receiving Exogenous Testosterone Therapy

Endogenous Cortisol and Testosterone Level in Central Serous Chorioretinopathy: A Case Control Study

Central Serous Chorioretinopathy With Multiple Leakage Points in a Young Female Patient Without Detected Risk Factors

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