Central precocious puberty: clinical and laboratory features*

Chemaitilly, Wassim; Trivin, Christine; Adan, Luís; Gall, Valérie; Sainte‐Rose, Christian; Brauner, Raja

doi:10.1046/j.1365-2265.2001.01229.x

Cited by 119 publications

(82 citation statements)

References 26 publications

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“…CPP is defined by the onset of pubertal development as a result of the premature activation of the HP-gonadal axis before the ages of 8 or 9 years in girls and boys respectively (63,64). Children with tumors located near the hypothalamus and optic pathways such as low-grade gliomas (with or without neurofibromatosis type 1) and with HP exposure to radiotherapy at doses 18-50 Gy are at risk of developing CPP (54, 65,66).…”

Section: Prevalence and Risk Factorsmentioning

confidence: 99%

DIAGNOSIS OF ENDOCRINE DISEASE: Endocrine late-effects of childhood cancer and its treatments

Chemaitilly

Cohen

2017

European Journal of Endocrinology

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Endocrine complications are frequently observed in childhood cancer survivors (CCS). One of two CCS will experience at least one endocrine complication during the course of his/her lifespan, most commonly as a late-effect of cancer treatments, especially radiotherapy and alkylating agent chemotherapy. Endocrine late-effects include impairments of the hypothalamus/pituitary, thyroid and gonads, as well as decreased bone mineral density and metabolic derangements leading to obesity and/or diabetes mellitus. A systematic approach where CCS are screened for endocrine late-effects based on their cancer history and treatment exposures may improve health outcomes by allowing the early diagnosis and treatment of these complications.

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Section: Prevalence and Risk Factorsmentioning

confidence: 99%

DIAGNOSIS OF ENDOCRINE DISEASE: Endocrine late-effects of childhood cancer and its treatments

Chemaitilly

Cohen

2017

European Journal of Endocrinology

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“…This tumor is composed of redundant brain tissue with a haphazard assembly of neurons, nerve fibers, and neuroglial cells in inappropriate distributions and proportions 8 .The association of hypothalamic hamartoma with precocious puberty has long been recognized. In fact hypothalamic hamartoma is one of the most common cerebral lesions associated with precocious puberty 9 .…”

Section: Discussionmentioning

confidence: 99%

“…Here the pattern and timing of pubertal events progresses in the normal sequence. 6 Eighty to ninety percent of GDPP will have no identifiable cause (idiopathic GDPP) and this condition will have a striking female predominance 7,8 . The other important causes include CNS tumors, trauma, infections, primary hypothyroidism, hydrocephalus, cysts etc 7 .…”

Section: Discussionmentioning

confidence: 99%

Precocious Puberty A Case Report

Begum¹,

Saha²,

Hassan³

2016

Bangladesh J Obstet Gynaecol

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The parents of a 04-year-old girl bring her to a Gynaecologist because of breast development, appearance of pubic hair and periodic per vaginal bleeding. Her medical history is unremarkable. The parents are of average height, and the mother reports first menstruating when she was 11 years old. At physical examination, the girl is 100 cm tall , weighs 17 kg, and has a bodymass index of 17. Her pubertal development is classified as Tanner stage 3 breast development and Tanner stage 2 pubic hair development. She was diagnosed as a case of precocious puberity. Appearance of secondary sexual development before the age of 9 in a male child and before the age of 8 in a female child is called precocious puberty. When the cause of precocious puberty is premature activation of the hypothalamic-pituitary axis, it is called central or complete precocious puberty and she was a case of central precocious puberty. After proper consult she was treated by GnRHa suppressor of pituitary till 11 years of age.Bangladesh J Obstet Gynaecol, 2015; Vol. 30(2) : 109-112

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“…Nos prontuários das 31 pacientes restantes (17,7%) foram relatados antecedentes familiais de PP (mãe em 14 casos). A menarca materna foi informada em 159 casos, tendo ocorrido aos 12,1 ± 0,1anos (8,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)0).…”

Section: Características Epidemiológicasunclassified

Puberdade precoce central idiopática em meninas no estado da Bahia

Aguiar

Couto-Silva

Freitas

et al. 2005

Arq Bras Endocrinol Metab

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RESUMOIntrodução: Embora os efeitos benéficos do tratamento com análogos de GnRH (GnRHa) na puberdade precoce central (PPC) estejam estabelecidos, aspectos clínicos podem variar em função do grupo racial. Objetivo e Métodos: Descrever o perfil de 175 meninas com PPC idiopática tratadas com GnRHa na Bahia, Brasil. Resultados: Houve predomínio do grupo racial mulato (73,6%). A puberdade iniciou-se aos 6,3 ± 0,1 anos. Ao diagnóstico, as crianças apresentavam estatura de 2,2 ± 0,1 DP e índice de massa corpórea (IMC) de 1,5 ± 0,1 DP (> 2 DP em 32%), estando este, inversamente associado (R= -0,20, p= 0,008) à idade no início da puberdade. As idades cronológica e óssea foram de 8,4 ± 0,1 anos e 10,3 ± 0,1 anos, respectivamente, ao início do tratamento. No seu término (n= 52), idade, IMC e estatura (n= 52) foram 10,6 ± 0,1 anos, 1,6 ± 0,2 DP e 1,9 ± 0,2 DP, respectivamente. Conclusão: Apresentação clínica e evolução puberal foram similares a outros estudos, independente do grupo racial. O tratamento com GnRHa não resultou em ganho de peso significativo na amostra estudada. To describe the profile of 175 girls from Bahia, Brazil, treated with GnRHa for idiopathic CPP. Results: The mulatto racial group predominated in the sample. The chronological age at puberty was 6.3 ± 0.1 years. At diagnosis, height was 2.2 ± 0.1 SD and body mass index (BMI) was 1.5 ± 0.1 SD (> 2 SD in 32%), this one, inversely associated with age at onset of puberty (R= -0.20, p= 0.008). At treatment, chronological and bone ages were 8.4±0.1 years and 10.3 ± 0.1 years, respectively. At the end of treatment (n= 52) age, BMI and height were 10.6 ± 0.1 years, 1.6 ± 0.2 SD and 1.9 ± 0.2 SD, respectively. Conclusion: Clinical presentation and evolution were similar to other studies, independently of racial characteristics. In this sample, treatment with GnRHa was not associated to significant weight gain. Keywords: Epidemiology; Puberty; Precocious puberty; Girls; GnRH analogues A PUBERDADE PRECOCE CENTRAL (PPC) é definida como o aparecimento de telarca antes dos 8 anos nas meninas e como o aumento do volume testicular antes dos 9 anos em meninos. Decorre da ativação prematura do eixo hipotálamo-hipófise-gonadal e é dita idiopática (PPCI) quando não se identificam lesões no SNC nos exames de imagem.

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Central precocious puberty: clinical and laboratory features*

Cited by 119 publications

References 26 publications

DIAGNOSIS OF ENDOCRINE DISEASE: Endocrine late-effects of childhood cancer and its treatments

DIAGNOSIS OF ENDOCRINE DISEASE: Endocrine late-effects of childhood cancer and its treatments

Precocious Puberty A Case Report

Puberdade precoce central idiopática em meninas no estado da Bahia

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Central precocious puberty: clinical and laboratory features*

Cited by 119 publications

References 26 publications

DIAGNOSIS OF ENDOCRINE DISEASE: Endocrine late-effects of childhood cancer and its treatments

DIAGNOSIS OF ENDOCRINE DISEASE: Endocrine late-effects of childhood cancer and its treatments

Precocious Puberty  A Case Report

Puberdade precoce central idiopática em meninas no estado da Bahia

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Precocious Puberty A Case Report