Central precocious puberty: A case report

Hypothalmic Hamartoma – A Rare Cause of Central Precocious Puberty

“…Patients with central precocious puberty are usually managed conservatively [2], for progressive central precocious puberty, treatment with a depot GnRH agonist is suggested and is generally continued for 11 years [2][3][4]. However, surgery including resection or disconnection through craniotomy or trans-spheroidal approach can be helpful in cases of poorly controlled epilepsy [2][3][4][5][6], to our patient, we advised long acting analogs agonists of GnRH (GnHas) with a follow up in OPD.…”

“…2 This condition may be asymptomatic for long period, or may present with clinical appearance and symptoms of precocious puberty and complex partial seizures refectory to anticonvulsant drugs [1,2]. One third of patients with hypothalamic hamartoma can be present with precocious puberty and it is defined as children attained the puberty before age of 8 years in girls and 9 years in boys [1,4,5]. Furthermore precocious puberty is divided into gonadotropin releasing hormone (GnRH)-dependent/central and gonadotropin releasing hormone (GnRH)-independent / peripheral precocious puberty [4].…”