Central Pontine Myelinolysis following Correction of Hyponatremia: MRI Diagnosis

Morlán, L; Rodríguez, Ernesto Suárez; Gonzalez, Javier; Jimenez-Ortiz, C; Escartín, P; Liaño, H. Avellón

doi:10.1159/000117333

Cited by 10 publications

(4 citation statements)

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“…Central pontine myelinolysis is also associated with rapid correction of hyponatraemia [23,24]. In 10% of cases extrapontine myelinolysis coexists, and in these cases the CC splenium can be affected ( Figure 10).…”

Section: Metabolic Pathologymentioning

confidence: 99%

The corpus callosum: white matter or terra incognita

Fitsiori

Nguyen²,

Karentzos³

et al. 2011

BJR

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The corpus callosum is the largest white matter structure in the brain, consisting of 200-250 million contralateral axonal projections and the major commissural pathway connecting the hemispheres of the human brain. The pathology of the corpus callosum includes a wide variety of entities that arise from different causes such as congenital, inflammatory, tumoural, degenerative, infectious, metabolic, traumatic, vascular and toxic agents. The corpus callosum, or a specific part of it, can be affected selectively. Numerous pathologies of the corpus callosum are encountered during CT and MRI. The aim of this study is to facilitate a better understanding and thus treatment of the pathological entities of the corpus callosum by categorising them according to their causes and their manifestations in MR and CT imaging. Familiarity with its anatomy and pathology is important to the radiologist in order to recognise its disease at an early stage and help the clinician establish the optimal therapeutic approach.

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Section: Metabolic Pathologymentioning

confidence: 99%

The corpus callosum: white matter or terra incognita

Fitsiori

Nguyen²,

Karentzos³

et al. 2011

BJR

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“…In our case, MRI Findings were consistent with CPM and showed High T2W/FLAIR signal in the pons with relative sparing of the periphery, in a ‘trident shaped’ appearance. The area appeared hypointense on T1W images with post contrast showing no significant enhancement [ [12] , [13] , [14] ].…”

Section: Discussionmentioning

confidence: 99%

Central pontine myelinolysis in a chronic alcoholic patient with mild hyponatremia: A case report

Dahal

Bhattarai

Bhattarai³

et al. 2022

Annals of Medicine &Amp; Surgery

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“…Magnetic resonance is a more sensitive neuro imaging method in diagnosis. In magnetic resonance imaging, hypointense signal changes in T1-weighted images and hyperintense signal changes in T2weighted images are observed at the areas of demyelination [12][13]. Diffusion limitation is defined in the myelinolysis areas at the beginning of the symptoms, but in some studies it is defined that diffusion findings shows late onset till 24 hours after the clinical symptoms [14].…”

Section: Discussionmentioning

confidence: 99%

Osmotic Demyelination Syndrome in a Normonatremic Patient of Chronic Kidney Disease

Ocak¹,

Urfalı²,

Korkmazer³

et al. 2019

meandros

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Santral pontin miyelinolizis olarak da bilinen osmotik demyelinizayon sendromu pons ve beynin bazal gangliyon, lateral genikulat cisimler, eksternal ve internal kapsül ve serebellumda miyelin kaybı ile giden nörolojik bir hastalıkdır. Osmotik demyelinizasyon sendromu hiponatreminin hızlı düzeltilmesi ile birlikte gelişen bir demyelinizasyon hastalığıdır. Klasik olarak hiponatremi ile ilişkilendirilse de, normonatremi varlığında da görülebilir. Lezyonların patogenezinde ozmolalitedeki değişiklikler sorumlu tutulmuştur. Hastalarda normal sodyum seviyelerinde deliryum kliniği ile birlikte pontin myelinozis nadiren de olsa tanımlanmıştır. Deliryum kliniği ile acil servise başvuran, kronik böbrek yetmezliği ile birlikte normonatremik santral pontin myelinozisli, 45 yaşında ki kadın hastanın klinik ve radyolojik bulgularını sunduk. Olgunun sunulmasında ki amaç, hasta normonatremik bile olsa pontin myelinozis gelişebileceğine dikkat çekerek; kalıcı hasar gelişmeden erken tedavi başlanmasının sekelli iyileşmeyi engelleyeceğini vurgulamaktı. Osmotic demyelination syndrome (ODS) also known as central pontine myelinolysis is a neurological disorder characterized by loss of myelin in the central pons as well as in the other parts of the brain like basal ganglia, lateral geniculate bodies, external and internal capsules and cerebellum. Osmotic demyelination syndrome is a demyelinating disorder associated with rapid correction of hyponatremia. Classically, this is associated with hyponatremia, but it can also occur in the presence of normonatremia. Changes in osmolality are found to be responsible in the pathogenesis of the lesions. Rarely, in patients having normal sodium levels, pontine myelinosis with delirium clinic was also described.We report the clinical and radiological findings of a normonatremic 45 years old woman patient with chronic kidney disease, suffering from central pontine myelinolysis.The aim of this report is to point the fact that pontine myelosis may occur in normon atremic circumstances and fast manangement of the disease before it is too late to defeat the permenant damage.

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Central Pontine Myelinolysis following Correction of Hyponatremia: MRI Diagnosis

Cited by 10 publications

References 0 publications

The corpus callosum: white matter or terra incognita

The corpus callosum: white matter or terra incognita

Central pontine myelinolysis in a chronic alcoholic patient with mild hyponatremia: A case report

Osmotic Demyelination Syndrome in a Normonatremic Patient of Chronic Kidney Disease

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