Central neurocytomas

Abstract

RESULTS.The overall 5-year survival and local control rates were 81% and 79%, Mark K. Lyons, M.D. 6 respectively. No patient developed metastases. The 5-year local control rate was 70% for patients undergoing subtotal resection (STR) and 100% for those undergo-1 Mayo Clinic Scottsdale, Department of Radiaing gross total resection (GTR) (P Å 0.08). The 5-year survival rate was 77% for tion Oncology, Scottsdale, Arizona.patients undergoing STR and 90% for those undergoing GTR (P Å 0.44). The effect 2 Mayo Clinic Rochester, Department of Patholof RT was evaluated for patients undergoing STR. The 5-year local control rate ogy, Rochester, Minnesota.was 100% for patients who received RT after STR compared with 50% for those who did not (P Å 0.02). The 5-year survival rate was 88% for patients who received 3 Mayo Clinic Rochester, Department of Radiation Oncology, Rochester, Minnesota.RT after STR compared with 71% for those who did not (P Å 0.3). Three patients received salvage RT for local progression after resection. All were alive and free of 4 Mayo Clinic Rochester, Department of Neuroldisease 1 to 6 years after RT. ogy, Rochester, Minnesota. Central neurocytomas generally occupy the lateral ventricles of young adults. Hydrocephalus is a common feature because these lesions tend to obstruct the foramen of Monro. Most straddle the midline, being attached to the septum pellucidum or less often, the walls of the lateral ventricles. CONCLUSIONS. GTR results in a very high likelihood of local control and survival.3 A minority occur within brain parenchyma or arise in the spinal cord. 4,5 In approximately 50% of neurocytomas, calcification is evident on radiographic or histologic examination. occasional perinuclear halos, delicate ''salt and pepper'' chromatin, and small distinct nucleoli. Mitoses are absent or infrequent and

Central neurocytoma: A clinical, radiological and pathological study of nine cases

“…Rades et al [29] found that incomplete tumor resection followed by radiotherapy was superior to incomplete resection alone with significantly better local control, but there was not a significant improvement in survival. Schild et al [30] demonstrated that the 5-year local control rate for residual central neurocytoma was 100% with radiation compared to 50% without radiation (p < 0.02). Kulkarni et al [27] followed up seven patients who were treated with whole brain irradiation after stereotactic biopsy.…”

Different Central Localizations, Different Histopathologies, Benefits, and Side Effects of Radiotherapy in Neurocytoma

“…The 10-year local control rates were 78.3% in GTR group, 92.3% in GTR+RT group, 37.7% in STR group, and 79.4% in STR+RT group. Similar findings were also published by Schild et al [27]; local control rate was found to be 100% for RT-added group, whereas it dropped to 50% in surgery-only group. The 5-year survival rates were not statistically significant in the two groups (88% vs 71%).…”

Dural Metastasis of Atypical Extraventricular Neurocytoma with the Codeletion of Chromosomes 1p/19q

“…Chemotherapy has only been used in a few EVN cases, including four patients who received chemotherapy after radiation, resulting in no tumour progression. 22 In a small patient series from the Mayo Clinic, two patients with EVN, with codeletions of 1p/19q, received temozolomide chemotherapy. 4 The present case received temozolomide chemotherapy after the second resection, but the effect of this treatment is unclear due to the brevity of the follow-up period, although the patient was well at the time of publication.…”