Central nervous system invasion by community-acquired meticillin-resistant Staphylococcus aureus

Abstract

We report a case of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) bacteraemia with cavernous sinus thrombosis, meningitis and brain abscess in a previously healthy American, who was employed in Belgium. We consecutively reviewed all published cases of CA-MRSA with central nervous system (CNS) involvement. A total of 12 similar cases were found, of which 11 were published in the last 4 years. Predominantly, young previously healthy subjects were affected (median age 28 years). The cases involved brain abscesses (5/12), disseminated disease (4/12), cavernous sinus thrombosis (2/12) and other (1/12). Infection origins were superficial skin infections (5/12), mostly of the face, sinusitis (1/12), otitis media (1/12), other or unknown (5/12). Although, in our review of the literature patients treated with linezolid had a better outcome compared to patients treated with vancomycin, the latter is still the mainstay of therapy for CNS infections associated with MRSA.

Community-acquired methicillin-resistant Staphylococcus aureus carrying SCCmec type IV in southern Brazil

“…However, in recent years, community-acquired methicillinresistant Staphylococcus aureus (CA-MRSA) infections have been reported worldwide [2][3][4][5] . CA-MRSA isolates frequently cause infections involving the skin and soft tissues, such as cellulites and abscesses, but they might be responsible for severe infections, such as necrotizing pneumonia and fasciitis, meningitis, bacteremia, and septic shock [6][7][8][9] .…”

Community-Acquired Methicillin-Resistant Staphylococcus Aureus (CA-MRSA) Brain Abscess

“…Reports of CA-MRSA infection of the central nervous system have been relatively rare (Naesens et al). 11 In this report, we describe a case of CA-MRSA brain abscess.…”

Cryptogenic brain abscess due to community-associated methicillin-resistant Staphylococcus aureus

“…Although historically considered as typical nosocomial pathogen, MRSA has rapidly emerged as a causative agent for community infections. [2] Risk factors for community acquisition are recent or frequent hospital admissions, frequent antibiotic exposure, chronic illness, prior surgery or a carrier in the family. [3] Recently, patients with no risk factors are presenting with community-associated MRSA (CA-MRSA) infections.…”