Central nervous system infections associated with neurologic devices

Bloch, Karen C.; Hasbun, Rodrigo

doi:10.1097/qco.0000000000000723

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…Generally, preoperative shaving or clipping hair is always necessary for cranial neurosurgical procedures and brain disease scale checks. , Cancer patients also may consider cutting their hair short before radiation therapy, which makes the change less dramatic and easier to cope with the hair loss. Meanwhile, it would be more persuasive if the therapeutic materials were derived from the patients themselves, which is helpful to easily obtain the patients’ hair before surgery.…”

Section: Introductionmentioning

confidence: 99%

Individual Human Hair Keratin Rapidly Extracted Through the Advanced Oxidation Process and Their Hemostatic and Wound Healing Evaluations

Deng,

Yuan,

Wang

et al. 2023

ACS Appl. Polym. Mater.

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Autogenous keratin is a promising material for personalized wound healing applications. However, the common keratin extraction methods are time-consuming, and the variations in performance between different individual keratins are not clear. Herein, we developed TiO2 photocatalytic-assisted H2O2 oxidation strategy (H2O2/TiO2/UV), an advanced oxidation method, to rapidly extract human hair keratins within 2 h. The H2O2/TiO2/UV method for keratin extraction showed a higher protein yield compared to the H2O2 method. Keratins obtained from the developed method exhibited typical chemical and secondary structures. Furthermore, individual keratins from four young girls were extracted by using the H2O2/TiO2/UV method, and individual keratin/PCL films were successfully fabricated within 5 h. More importantly, individual keratin films displayed superior hemostatic performance and wound healing in vivo compared to that of keratin extracted via the H2O2 method. Interestingly, the four individual keratin films exhibited similar hemostatic efficiency but distinct wound-healing properties in terms of epidermal thickness and density of skin appendages. These data indicated that the developed H2O2/TiO2/UV method is an efficient and feasible approach to extract human hair keratins, which provides an intriguing possibility to explore personalized materials for promoting wound healing.

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Section: Introductionmentioning

confidence: 99%

Individual Human Hair Keratin Rapidly Extracted Through the Advanced Oxidation Process and Their Hemostatic and Wound Healing Evaluations

Deng,

Yuan,

Wang

et al. 2023

ACS Appl. Polym. Mater.

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Systematic review of efficacy, safety and pharmacokinetics of intravenous and intraventricular vancomycin for central nervous system infections

et al. 2022

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Objective: The decision of vancomycin dosage for central nervous system (CNS) infections is still a challenge because its bactericidal nature in cerebrospinal fluid (CSF) has not been confirmed by human studies. This study systematically reviewed the literatures on vancomycin in patients with meningitis, ventriculitis, and CNS device-associated infections, to assess efficacy, safety, and pharmacokinetics to better serve as a practical reference.Methods: Medline, Embase, and Cochrane Library were searched using terms vancomycin, Glycopeptides, meningitis, and central nervous system infections. Data were extracted including characteristics of participants, causative organism(s), administration, dosage, etc., The clinical response, microbiological response, adverse events and pharmacokinetic parameters were analyzed.Results: Nineteen articles were included. Indications for vancomycin included meningitis, ventriculitis, and intracranial device infections. No serious adverse effects of intravenous (IV) and intraventricular (IVT) vancomycin have been reported. Dosages of IV and IVT vancomycin ranged from 1000–3000 mg/day and 2–20 mg/day. Duration of IV and IVT vancomycin therapy most commonly ranged from 3–27 days and 2–21 days. Therapeutic drug monitoring was conducted in 14 studies. Vancomycin levels in CSF in patients using IV and IVT vancomycin were varied widely from 0.06 to 22.3 mg/L and 2.5–292.9 mg/L. No clear relationships were found between vancomycin CSF levels and efficacy or toxicity.Conclusion: Using vancomycin to treat CNS infections appears effective and safe based on current evidence. However, the optimal regimens are still unclear. Higher quality clinical trials are required to explore the vancomycin disposition within CNS.

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Central nervous system infections associated with neurologic devices

Cited by 2 publications

References 41 publications

Individual Human Hair Keratin Rapidly Extracted Through the Advanced Oxidation Process and Their Hemostatic and Wound Healing Evaluations

Individual Human Hair Keratin Rapidly Extracted Through the Advanced Oxidation Process and Their Hemostatic and Wound Healing Evaluations

Systematic review of efficacy, safety and pharmacokinetics of intravenous and intraventricular vancomycin for central nervous system infections

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