Central Neck Dissection for Papillary Thyroid Cancer

Rosenbaum, Michael; McHenry, Christopher R.

doi:10.1001/archoto.2009.158

Cited by 63 publications

(49 citation statements)

References 27 publications

(29 reference statements)

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“…Proponents of prophylactic central neck dissection have demonstrated that prophylactic neck dissection may reduce postoperative serum thyroglobulin (Tg) levels and improve short-term recurrence rates [42][43][44]. However, there remains little evidence to suggest that microscopic disease, not visible on preoperative imaging or intraoperative palpation, is associated with poorer outcomes.…”

Section: • Controversy Over Management Of Nodal Diseasementioning

confidence: 99%

Nodal Metastases in Thyroid Cancer: Prognostic Implications and Management

Wang

Ganly

2016

Future Oncol.

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The significance of cervical lymph node metastases in differentiated thyroid cancer has been controversial and continues to evolve. Current staging systems consider nodal metastases to confer a poorer prognosis, particularly in older patients. Increasingly, the literature suggests that characteristics of the metastatic lymph nodes such as size and number are also prognostic. There is a growing trend toward less aggressive treatment of low-volume nodal disease. The aim of this review is to summarize the current literature and discuss prognostic and management implications of lymph node metastases in differentiated thyroid cancer.

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Section: • Controversy Over Management Of Nodal Diseasementioning

confidence: 99%

Nodal Metastases in Thyroid Cancer: Prognostic Implications and Management

Wang

Ganly

2016

Future Oncol.

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“…On the other hand, prophylactic central and/or lateral lymph node dissection for clinically node negative patients is controversial. Central lymph node dissection can cause considerable morbidity such as permanent damage to parathyroid glands and recurrent laryngeal nerves [11][12][13]. Sentinel node mapping may be especially helpful in clinically node negative thyroid cancer patients to avoid unnecessary lymph node dissection in sentinel node negative patients.…”

Section: Introductionmentioning

confidence: 99%

Mapowanie węzłów wartowniczych w raku brodawkowatym tarczycy z zastosowaniem radioznacznika i niebieskiego barwnika

Assadi¹,

Yarani²,

Jangjoo³

et al. 2014

Endokrynologia Polska

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Introduction: In the current study, we evaluated the accuracy of sentinel node mapping in thyroid cancer patients using both radiotracer and blue dye. Material and methods: 30 patients with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study; 2-3 hours before surgery, 0.5 mCi 99m-Tc-Antimony Sulfide Colloid was injected intra-tumourally. 15 minutes post-injection, lymphoscintigraphy images of the neck were obtained. Immediately after anaesthesia induction, 0.5 mL patent blue V was also injected in the same fashion. Sentinel lymph nodes were detected intraoperatively using gamma probe and blue dye. Total thyroidectomy was performed for all patients with dissection of central neck lymph nodes as well as sampling of the lateral neck lymph nodes. Results: At least one sentinel node could be identified during surgery in 19 patients (63.3%). The median number of sentinel nodes per patient was 1. Sentinel nodes in 12 patients were pathologically involved. No false negative case was noted. Upstaging occurred in six patients (20%). Conclusions: Sentinel node mapping in papillary thyroid carcinoma is a feasible technique with high accuracy for the detection of lymph node involvement. This technique can guide surgeons to perform central lymph node dissection only in patients with pathologically involved sentinel nodes. Although SLN detection in the lateral neck lymph nodes increases the extension of lymphadenectomy, SLN mapping can result in upstaging in older patients (> 45 years of age) or treatment plan change in younger patients (< 45 years of age) by the detection of lateral lymph node involvement. (Endokrynol Pol 2014; 65 (4): 281-286)

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“…Increased risk of transient hypoparathyroidism has been consistently shown in many studies. (Sywak et al, 2006;Hughes et al 2010;Lang et al,2011c;Palestini et al,2008;Roh et al,2007;Moo et al,2010;Rosenbaum et al,2009) The higher rate of temporary hypoparathyroidism could be explained by the higher rate of unintentional removal of parathyroid glands (i.e. unintentional parathyroidectomy) and subsequent auto-transplantation.…”

Section: First Author /Year Of Publicationmentioning

confidence: 99%

“…In terms of temporary recurrent laryngeal nerve injury, Palestini et al reported a higher rate of transient recurrent laryngeal nerve injury in patients undergoing thyroidectomy plus unilateral pCND (5.4% vs. 1.4%, p< 0.05) (Palestini et al,2008) while other studies failed to show any statistically significant differences. (Sywak et al, 2006;Hughes et al 2010;Lang et al,2011;Roh et al,2007;Sadowski et al2009;Rosenbaum et al,2009) To date, no studies have shown an increase risk of permanent hypoparathyroidism or recurrent laryngeal nerve injury. A recent systematic review comprising 5 retrospective studies evaluated the morbidity of pCND and found that there was one extra case of transient hypocalcaemia for every eight pCND performed.…”

Section: First Author /Year Of Publicationmentioning

confidence: 99%