Central Granular Cell Odontogenic Tumor of the Maxilla

Abstract

The central granular cell odontogenic tumor (CGCOT) is a rare benign odontogenic neoplasm composed of varying amounts of large eosinophilic granular cells and apparently inactive odontogenic epithelium. It tends to occur as a small asymptomatic swelling in the posterior region of the mandible with nonaggressive appearance. We report an unusual case of CGCOT in the maxillary region with clinical features of malignancy. The patient underwent surgical treatment, and the 2-year follow-up revealed no signs of recurrence. Central granular cell odontogenic tumor is a very rare condition with few cases reported, especially in the maxillary region. This case highlights the possibility of aggressive behavior by these lesions.

A granular‐cell odontogenic tumour occurring alongside orofacial granulomatosis: a report of the first case

“…The lesion is most common in females. In contrast to the case described in this report, a high proportion of cases are observed in patients of 60 to 80 years in age. It is typically observed on clinical examination as an asymptomatic buccal expansion of the posterior mandible.…”

“…Granular‐cell odontogenic tumours (GCOTs) are benign odontogenic neoplasms that often present as an asymptomatic swelling of the mandible. They are observed most commonly in middle‐aged women. Diagnosis is by biopsy and histological examination, and treatment involves either surgical excision or curettage.…”

Central granular cell odontogenic tumor: a systematic review

“…Central granular cell odontogenic tumor usually presents as an asymptomatic slowly growing swelling of the jaw bones . However, it can present as a painful ulceration of the alveolar ridge and palate . Size of the lesion ranges from 0.5 to 8.0 cm (average 2.8 cm) and duration from 5 months to 19 years .…”

“…Central granular cell odontogenic tumor is an extraordinarily rare condition. Only 38 cases have been reported in the literature till date . The aim of the present review article is to comprehensively review the nomenclature, clinical, radiological, histopathological, histogenetic, and treatment aspects of the CGCOT published in the English medical literature.…”

“…Reference lists from the citations were also reviewed for the relevant publications. A total of 37 papers were obtained from the initial search . The case reports or case series with confirmed histopathological diagnosis of CGCOT or histopathological features suggestive of CGCOT but reported with other terminologies (mentioned in the nomenclature) were identified.…”