Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic

Aghaian, E.; Choe, Joyce; Lin, Shan; Stamper, Robert L.

doi:10.1016/j.ophtha.2004.06.013

Cited by 293 publications

(270 citation statements)

References 29 publications

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“…In addition to our study, other researchers have found a significant thinning of the central cornea with age. 8,10,19,20 Two studies which also only recruited older participants, failed to detect a significant relationship. [21][22][23][24] The changes in structural corneal biomechanics with subject age adds further complexity to the relationship between CCT and Goldmann IOP.…”

Section: Discussionmentioning

confidence: 97%

“…11 In these samples, the substantial confounding effects of IOP, as measured by applanation, which may have a nonlinear relationship with CCT, 18 and those of the glaucomatous process, may make isolation of the relationship between CCT and ONH difficult. Age is a further confounding factor since CCT decreases, 10,19,20 and POAG prevalence increases, with advancing years. In addition, limitations of the CCT measurement protocol in the OHTS study 3 may make the finding of a statistically independent relationship between CCT and the risk of POAG development unreliable.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 These findings are replicated among different racial groups. 10 In addition, in a multivariate analysis of baseline factors predicting the conversion of OHT into POAG within OHTS, CCT was retained as a risk factor independent of its relationship with IOP. 3 Speculative proposals on the mechanism of this IOP-independent interaction reflect the nature of the cornea as an extension of the sclera.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

Hawker

Edmunds

Vernon

et al. 2007

Eye

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Purpose To determine population-based normative CCT data for elderly white subjects, with and without diabetes, and to explore the relationship between CCT and IOP and HRT2 measurements in such subjects with normal visual fields. Methods All eligible subjects were consecutive in a population screened for eye disease. CCT was measured by ultrasound pachymetry, and the optic disc was morphometrically defined using Heidelberg retinal tomography (HRT2). Inclusion criteria were: (1) normal visual field on suprathreshold testing and (2) corrected logMAR acuity of at least 0.3 in both eyes. Subjects with significant corneal pathology, previous corneal surgery, or known history of glaucoma or treatment for raised intraocular pressure were excluded. One eye was randomly selected from each subject for analysis. Results In all, 983 eyes of 983 subjects were included with 690 HRT images deemed acceptable for the analysis. The mean age (414 men and 569 women) was 73.3 years (minimum 65 years). Mean (SD) CCT was 544.1 (36.5) lm, with a normally distributed range of 429-633 lm. There was no significant difference in CCT between men and women (mean CCT 546.1 and 542.7 lm, respectively, P ¼ 0.15, Student's t-test), though CCT was correlated weakly and negatively with age (Pearson's r ¼ À0.063, P ¼ 0.047). Diabetic patients (n ¼ 103) had a greater mean CCT than non-diabetic patients (551.9 and 543.0 lm respectively, P ¼ 0.02). No significant correlation was found between any global optic disc parameter and CCT in the 690 eyes analysed. Conclusion Elderly white eyes with normal fields have CCTs that are normally distributed, with those from diabetic persons having greater CCTs. No clear evidence of a relationship between CCT and HRT2 optic disc parameters used in glaucoma diagnosis was found.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

Hawker

Edmunds

Vernon

et al. 2007

Eye

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“…In a clinic-based study, investigators described no significant difference in corneal thickness between Chinese, Caucasian, Filipino, and Hispanic participants, but Japanese participants had significantly thinner corneas, whereas corneas of African-Americans were still thinner. 9 It has been hypothesized that a thin cornea is a risk factor for glaucoma, aside from the associated intraocular pressure measurement error. 10 Exploring this assertion, several investigators have however been unable to find a relationship between corneal thickness and retinal nerve fibre layer (RNFL) thickness in healthy or ocular hypertensive eyes by the use of scanning laser polarimetry (SLP), confocal scanning laser ophthalmoscopy (CSLO), and optical coherence tomography (OCT).…”

Section: Corneamentioning

confidence: 99%

Ethnicity and ocular imaging

Bourne

2010

Eye

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There exist ethnic differences in the prevalence of many ocular diseases. The ocular structures affected by these diseases can be imaged with devices that have increased in complexity over recent years. The purpose of this review is to explore what we mean by the term 'ethnicity' and what we know of ethnic differences in the structures of the eye that are commonly imaged. Finally, the implications of these ethnic differences are discussed in relation to the detection and monitoring of ocular disease that involves imaging instruments.

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“…It is a measure of tissue mass and perhaps an estimator of corneal rigidity (7) . However, CCT varies among ethnic groups and also demonstrates strong heritability in nuclear families (17)(18) . The in vivo measurement of corneal resistance to deformation was enabled by the development of the ocular response analyzer (ORA) by Luce (19) .…”

Section: Introductionmentioning

confidence: 99%

Corneal biomechanical evaluation in healthy thin corneas compared with matched keratoconus cases

Fontes¹,

Ambrósio²,

Velarde³

et al. 2011

Arq. Bras. Oftalmol.

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Purpose: To evaluate and compare corneal hysteresis (CH) and corneal resistance factor (CRF) in healthy eyes with a central corneal thickness (CCT) ≤ 505 μm with CH and CRF in gender-, age-, and CCT-matched keratoconus cases, and to estimate the sensitivity and specificity of these parameters for discriminating between the two groups. Methods: Prospective, comparative case series. In total 46 eyes from 30 healthy patients with CCT ≤ 505 μm, and 42 eyes from 30 CCT-, gender-and age-matched keratoconus cases were enrolled. Biomechanical metrics (CH and CRF) were measured using the Ocular Response Analyzer (ORA) and then compared. A receiver operating characteristic (ROC) curve was used to identify cut-off points to maximize the sensitivity and specificity for discriminating between the groups. Results: The CCT was 485.96 ± 17.61 μm (range, 438 -505) in healthy thin corneas and 483.64 ± 16.19 μm (range, 452 -505) in keratoconus; p=0.5225. CH was 8.63 ± 1.23 mmHg (range, 5.95 -12.2) and 8.07 ± 1.17 mmHg (range, 4.9 -9.85), respectively; p=0.0312. CRF was 8.43 ± 1.29 mmHg (range, 5.45 -11.10) and 7.22 ± 1.34 mmHg (range, 4.7 -9.45), respectively; p<0.001. ROC curve analysis showed a poor overall predictive accuracy of CH (cut-off, 8.95 mmHg; sensitivity, 63%; specificity, 23.8%; test accuracy, 44.30%) and CRF (cut-off, 7.4 mmHg; sensitivity, 28.3%; specificity, 40.5%; test accuracy, 34.12%) for detecting keratoconus in the eyes studied. Conclusion: CH and CRF were statistically lower in keratoconus than in healthy thin corneas. However, CH and CRF offered very low sensitivity and specificity for discriminating the groups.Keywords: Cornea/physiology; Keratoconus; Corneal diseases; Biomechanics/physiology; Diagnostic techniques, ophthalmological RESUMOObjetivo: Avaliar e comparar a histerese corneana (CH) e o fator de resistência corneano (CRF) em olhos saudáveis com espessura corneana central (CCT) ≤ 505 μm com os resultados de CH e CRF em pacientes com ceratocone pareados por sexo, idade e CCT, além de estimar a sensibilidade e especificidade destes parâmetros na diferenciação dos grupos. Métodos: Estudo prospectivo, do tipo série de casos comparativa. No total, 46 olhos de 30 pacientes saudáveis com CCT ≤ 505 μm, e 42 olhos de 30 pacientes com ceratocone pareados por sexo, idade e CCT foram incluídos. Os parâmetros biomecânicos (CH e CRF) foram obtidos através do equipamento Ocular Response Analyzer (ORA) e depois comparados. Curvas ROC (Receiver operating characteristic) foram utilizadas para identificar o melhor valor de corte que apresentasse a maior sensibilidade e especificidade na discriminação entre ceratocone e córneas finas saudáveis para cada dado estudado. Resultados: A CCT encontrada foi 485,96 ± 17,61 μm (de 438 a 505) no grupo de córneas finas saudáveis e 483.64 ± 16,19 μm (de 452 a 505) no grupo ceratocone; p=0,5225. CH 8,63 ± 1,23 mmHg (de 5,95 a 12,2) e 8,07 ± 1,17 mmHg (de 4,9 a 9,85), respectivamente; p=0,0312. CRF 8,43 ± 1,29 mmHg (de 5,45 a 11,10) e 7,22 ± 1,34 mmHg (de 4,7 a 9,45), resp...

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Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic

Cited by 293 publications

References 29 publications

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

Ethnicity and ocular imaging

Corneal biomechanical evaluation in healthy thin corneas compared with matched keratoconus cases

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