Central Corneal Thickness (CCT) in Diabetic Subjects and its Correlation with Disease Duration and Severity

Dabas, Ruchi; Sethi, Sumita; Garg, Monal; Aggarwal, Ramnika; Lamba, Sonika; Bhattacharjee, Angshupriya; Tandon, Anupama

doi:10.21276/aimdr.2017.3.5.ot2

Cited by 7 publications

(10 citation statements)

References 4 publications

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“…This eventually results in anatomical and functional changes in the cornea. (9) In our study mean CCT was thicker in diabetic groups when compared with the non-diabetics.The difference between the 2 groups was statistically significant (p<0.05)…”

Section: Discussion:-supporting

confidence: 53%

“…Diabetes effects cornea by causing corneal endothelial damage and recurrent corneal erosions and persistent epithelial defects. (9) 7. DM affects Na + -K + ATP ase pump, thus causing functional changes in diabetic corneas.…”

mentioning

confidence: 99%

“…DM affects Na + -K + ATP ase pump, thus causing functional changes in diabetic corneas. (9) Aim of the study:-To evaluate central corneal thickness among Type 2 diabetics and age matched controls.…”

mentioning

confidence: 99%

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Evaluation of Central Corneal Thickness Among Type 2 Diabetics and Age Matched Controls a Comparative Study

M.B.B.S¹,

DGO²

2019

IJAR

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Aim: To evaluate central corneal thickness(CCT) among Type 2 diabetics and age matched controls. Materials and Methods: it is a hospital based cross-sectional study having Study period between March 2019-June 2019, and this study conducted at Govt Regional Eye hospital, Visakhapatnam , having sample size of 200 eyes of 100 individuals. Results: Mean CCT in diabetics were 526.8+/-6.741 and mean cct in non diabetics were 508.8+/-5.027 microns. Conclusion: CCT significantly more in Diabetics compared to non diabetics and further severity of retinopathy does not significantly affect CCT.

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Section: Discussion:-supporting

confidence: 53%

mentioning

confidence: 99%

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Evaluation of Central Corneal Thickness Among Type 2 Diabetics and Age Matched Controls a Comparative Study

M.B.B.S¹,

DGO²

2019

IJAR

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“…Dabas R, Sethi S et al found central corneal thickness higher in diabetics with HbA1C>7 (564.44±32.01 μm) in comparison to HbA1C<7 (543.85±23.32μm) (p < 0.009) [12].…”

Section: Original Research Articlementioning

confidence: 94%

Comparison of the central corneal thickness in diabetes mellitus patients and non diabetics individuals

Math

Mohta

2017

Trop J Ophthalmol Otolaryngol

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Background: Diabetes is associated with increase in the thickness of the cornea and also raised intraocular pressure as compared to normal healthy individuals.Diabetes causes intrinsic abnormality of the epithelial basement membrane complex & impairs epithelial and endothelial barrier function.A few studies have been done on corneal morphological changes, corneal thickness in diabetic subjects but it is still a topic of research in Indian population. Purpose:To compare the central corneal thickness in diabetes mellitus patients and non diabetics individuals. Method: A Prospective observational study with 100 patients, 50 diabetic and 50 non-diabetics subjects was conducted from 1 st February 2019 to 30 th April 2019. All subjects underwent routine complete ophthalmological examination, central corneal thickness was measured using ultrasound pachymetery. Blood investigation like fasting blood sugars, postprandial sugars, and HbA1c levels was done among diabetics and random blood sugars were done among non diabetic subjects. Results: The mean central corneal thickness in diabetic subjects was 558.8±24.71µm as compared to non-diabetics 524.33±14.26µm and difference between the two groups was clinically significant (p<0.0001). The central corneal thickness was higher for diabetes with duration of >10 years (567.74±5.30µm) when compared to duration of diabetes <10 years (550.54±13.41µm) and with HbA1c >6.5% showed statistically significant increase in mean central corneal thickness compared to HbA1c <6.5%. Conclusion: Diabetic subjects showed higher central corneal thickness as compared to nondiabetic subjects and also there was increase in central corneal thickness with increase in duration and uncontrolled diabetes. All diabetic patients need to undergo central corneal thickness assessment before any intraocular surgeries.

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“…The hemostasis of various structures of cornea can be altered by the diabetes in both the non-stressed and stressed cornea, causing myriad primary and postoperative manifestations. They have abnormalities like higher corneal autofluorescence, lower corneal sensitivity and lesser endothelial density [4] . Diabetic keratopathy is a frequent disease that entails several alterations, especially in the epithelium and endothelium in diabetics.…”

Section: Introductionmentioning

confidence: 99%

Variation in central corneal thickness in diabetes: A comparative prospective study at a tertiary care hospital

Jacob¹,

Isaac²,

Salor³

et al. 2020

Int. J. Med. Ophthalmol.

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Diabetes being the greatest challenge of the century and the fact that it affects almost all of the tissues and organs in the body warrants research into the effects of diabetes on every structure. This study was designed with the aim of finding out any association between diabetes and central corneal thickness and to evaluate the effect of diabetes treatment on central corneal thickness. Objectives a. To find out the differences between CCT values amongst diabetic and non-diabetic patients, if any. b. To assess the presence of any significant change in these measurements after successful control of hyperglycaemia. Methods: A comparative prospective study was conducted in the Dept. of Ophthalmology, Sree Mookambika Institute of Medical Sciences, Kulasekharam to evaluate the effect of diabetes on CCT. A total of 84 subjects were studied which included 42 diabetics. After thorough systemic and ocular CCT was measured using ultrasound pachymeter. The study was initiated after obtaining ethical clearance from the institution's ethical clearance committee. The collected data was analysed using SPSS software version 20.0. Results: Majority of the study subjects were male in both diabetic group (52.4%) and non-diabetic group (54.8%). The mean CCT among non-diabetics were 529 and among diabetics were 554.5. Students 't' test was used to compare the corneal thickness between diabetic and non-diabetic patients. P value less than 0.05 is considered as significant. In this study it is found that there is significant difference in CCT OD 1 and CCT OS 1 in diabetic and non-diabetic patients. And the difference in CCT was found to be statistically significant. In this study we have also found out that there is strong positive correlation between CCT and diabetic control as per the pearson coefficient evaluation. In this study it is found that there is no significant difference in CCT following diabetic control in diabetic patients. Also, CCT was not correlated with the duration of diabetes. But the effect of control was not evaluated with serial HbA1c and a few patients didn't have good control of diabetes either. Conclusion:Diabetes is a serious and extremely prevalent systemic illness in today's scenario which was previously considered a disease of the affluent, diabetes has become a problem of epidemic proportions, contributing to significant morbidity and mortality. And India is moving fast in this race to become a Diabetes Capital of the world. Such being the case, it warrants further research in the field by the medical fraternity, to aid in prevention, early diagnosis, delaying progression and management of the disease. The effects of diabetes on the eye have been studied but as the prevalence of diabetes increases with all the generation, it demands further detailed research activities into the effect's diagnosis and management of diabetes in the eye. In our study we tried to bring to light the effects of diabetes on corneal thickness, which in turn might affect even the management of glaucoma. We evaluated a group of d...

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Central Corneal Thickness (CCT) in Diabetic Subjects and its Correlation with Disease Duration and Severity

Cited by 7 publications

References 4 publications

Evaluation of Central Corneal Thickness Among Type 2 Diabetics and Age Matched Controls a Comparative Study

Evaluation of Central Corneal Thickness Among Type 2 Diabetics and Age Matched Controls a Comparative Study

Comparison of the central corneal thickness in diabetes mellitus patients and non diabetics individuals

Variation in central corneal thickness in diabetes: A comparative prospective study at a tertiary care hospital

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